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Title:
Inefficient Clearance of Dying Cells and Autoreactivity | SpringerLink
Description:
Dying cells were basically unnoticed by scientists for a long time and only came back into the spotlight roughly 10 years ago. The process of recognition and uptake of apoptotic and necrotic cells is complex and failures in this process can contribute to the...
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Questions {❓}

Chionna A, Panzarini E, Pagliara P, De Luca A, Caforio S, Abbro L, Dini L (2003) Hepatic clearance of apoptotic lymphocytes: simply removal of waste cells?

Schema {🗺️}

ScholarlyArticle:
      headline:Inefficient Clearance of Dying Cells and Autoreactivity
      pageEnd:176
      pageStart:161
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-540-29714-7.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Current Concepts in Autoimmunity and Chronic Inflammation
         isbn:
            978-3-540-29714-7
            978-3-540-29713-0
         type:Book
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:U. S. Gaipl
            affiliation:
                  name:Friedrich-Alexander-University of Erlangen-Nuremberg
                  address:
                     name:Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:A. Sheriff
            affiliation:
                  name:Friedrich-Alexander-University of Erlangen-Nuremberg
                  address:
                     name:Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:S. Franz
            affiliation:
                  name:Friedrich-Alexander-University of Erlangen-Nuremberg
                  address:
                     name:Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:L. E. Munoz
            affiliation:
                  name:Friedrich-Alexander-University of Erlangen-Nuremberg
                  address:
                     name:Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:R. E. Voll
            affiliation:
                  name:Nikolaus-Fiebiger Center of Molecular Medicine
                  address:
                     name:IZKF Research Group N2, Nikolaus-Fiebiger Center of Molecular Medicine, Erlangen, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:J. R. Kalden
            affiliation:
                  name:Friedrich-Alexander-University of Erlangen-Nuremberg
                  address:
                     name:Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:M. Herrmann
            affiliation:
                  name:Friedrich-Alexander-University of Erlangen-Nuremberg
                  address:
                     name:Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Systemic Lupus Erythematosus, Apoptotic Cell, Systemic Lupus Erythematosus Patient, Follicular Dendritic Cell, Cell Death Differ
      description:Dying cells were basically unnoticed by scientists for a long time and only came back into the spotlight roughly 10 years ago. The process of recognition and uptake of apoptotic and necrotic cells is complex and failures in this process can contribute to the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE). Here, we discuss the recognition and uptake molecules which are involved in an efficient clearance of dying cells in early and late phases of cell death. The exposure of phosphatidylserine (PS) is an early surface change of apoptosing cells recognized by several receptors and adaptor molecules. We demonstrated that dying cells have cell membranes with high lateral mobility of PS, which contribute to their efficient clearance. Changes of the glycoprotein composition of apoptotic cells occur later than the exposure of PS. We further observed that complement binding is an early event in necrosis and a rather late event in apoptosis. Complement, C-reactive protein (CRP), and serum DNase I act as back-up molecules in the clearance process. Finally, we discuss how the accumulation of secondary necrotic cells and cellular debris in the germinal centers of secondary lymphorgans can lead toautoimmunity. It is reasonable to argue that clearance defects are major players in the development of autoimmune diseases such as SLE.
      datePublished:2006
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Book:
      name:Current Concepts in Autoimmunity and Chronic Inflammation
      isbn:
         978-3-540-29714-7
         978-3-540-29713-0
Organization:
      name:Springer Berlin Heidelberg
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         type:ImageObject
      name:Friedrich-Alexander-University of Erlangen-Nuremberg
      address:
         name:Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany
         type:PostalAddress
      name:Friedrich-Alexander-University of Erlangen-Nuremberg
      address:
         name:Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany
         type:PostalAddress
      name:Friedrich-Alexander-University of Erlangen-Nuremberg
      address:
         name:Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany
         type:PostalAddress
      name:Friedrich-Alexander-University of Erlangen-Nuremberg
      address:
         name:Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany
         type:PostalAddress
      name:Nikolaus-Fiebiger Center of Molecular Medicine
      address:
         name:IZKF Research Group N2, Nikolaus-Fiebiger Center of Molecular Medicine, Erlangen, Germany
         type:PostalAddress
      name:Friedrich-Alexander-University of Erlangen-Nuremberg
      address:
         name:Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany
         type:PostalAddress
      name:Friedrich-Alexander-University of Erlangen-Nuremberg
      address:
         name:Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany
         type:PostalAddress
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Person:
      name:U. S. Gaipl
      affiliation:
            name:Friedrich-Alexander-University of Erlangen-Nuremberg
            address:
               name:Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany
               type:PostalAddress
            type:Organization
      name:A. Sheriff
      affiliation:
            name:Friedrich-Alexander-University of Erlangen-Nuremberg
            address:
               name:Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany
               type:PostalAddress
            type:Organization
      name:S. Franz
      affiliation:
            name:Friedrich-Alexander-University of Erlangen-Nuremberg
            address:
               name:Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany
               type:PostalAddress
            type:Organization
      name:L. E. Munoz
      affiliation:
            name:Friedrich-Alexander-University of Erlangen-Nuremberg
            address:
               name:Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany
               type:PostalAddress
            type:Organization
      name:R. E. Voll
      affiliation:
            name:Nikolaus-Fiebiger Center of Molecular Medicine
            address:
               name:IZKF Research Group N2, Nikolaus-Fiebiger Center of Molecular Medicine, Erlangen, Germany
               type:PostalAddress
            type:Organization
      name:J. R. Kalden
      affiliation:
            name:Friedrich-Alexander-University of Erlangen-Nuremberg
            address:
               name:Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany
               type:PostalAddress
            type:Organization
      name:M. Herrmann
      affiliation:
            name:Friedrich-Alexander-University of Erlangen-Nuremberg
            address:
               name:Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany
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      name:Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany
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      name:Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany
      name:Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany
      name:IZKF Research Group N2, Nikolaus-Fiebiger Center of Molecular Medicine, Erlangen, Germany
      name:Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany
      name:Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany
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