We are analyzing https://link.springer.com/chapter/10.1007/128_2012_340.

Title:
A Perspective on Dietary Phytochemicals and Cancer Chemoprevention: Oxidative Stress, Nrf2, and Epigenomics | SpringerLink
Description:
Oxidative stress is caused by an imbalance of reactive oxygen species (ROS)/reactive nitrogen species (RNS) and the antioxidative stress defense systems in cells. ROS/RNS or carcinogen metabolites can attack intracellular proteins, lipids, and nucleic acids, which...
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Topics {✒️}

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      headline:A Perspective on Dietary Phytochemicals and Cancer Chemoprevention: Oxidative Stress, Nrf2, and Epigenomics
      pageEnd:162
      pageStart:133
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-642-34575-3.jpg
      genre:
         Chemistry and Materials Science
         Chemistry and Material Science (R0)
      isPartOf:
         name:Natural Products in Cancer Prevention and Therapy
         isbn:
            978-3-642-34575-3
            978-3-642-34574-6
         type:Book
      publisher:
         name:Springer Berlin Heidelberg
         logo:
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      author:
            name:Zheng-Yuan Su
            affiliation:
                  name:the State University of New Jersey
                  address:
                     name:Department of Pharmaceutics, Center for Cancer Prevention Research, Ernest-Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Limin Shu
            affiliation:
                  name:the State University of New Jersey
                  address:
                     name:Department of Pharmaceutics, Center for Cancer Prevention Research, Ernest-Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Tin Oo Khor
            affiliation:
                  name:the State University of New Jersey
                  address:
                     name:Department of Pharmaceutics, Center for Cancer Prevention Research, Ernest-Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jong Hun Lee
            affiliation:
                  name:the State University of New Jersey
                  address:
                     name:Department of Pharmaceutics, Center for Cancer Prevention Research, Ernest-Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Francisco Fuentes
            affiliation:
                  name:the State University of New Jersey
                  address:
                     name:Department of Pharmaceutics, Center for Cancer Prevention Research, Ernest-Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, USA
                     type:PostalAddress
                  type:Organization
                  name:Universidad Arturo Prat
                  address:
                     name:Departamento de Agricultura del Desierto y Biotecnología, Universidad Arturo Prat, Iquique, Chile
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ah-Ng Tony Kong
            affiliation:
                  name:the State University of New Jersey
                  address:
                     name:Department of Pharmaceutics, Center for Cancer Prevention Research, Ernest-Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Antioxidant response, Inflammation, Keap1, Nrf2
      description:Oxidative stress is caused by an imbalance of reactive oxygen species (ROS)/reactive nitrogen species (RNS) and the antioxidative stress defense systems in cells. ROS/RNS or carcinogen metabolites can attack intracellular proteins, lipids, and nucleic acids, which can result in genetic mutations, carcinogenesis, and other diseases. Nrf2 plays a critical role in the regulation of many antioxidative stress/antioxidant and detoxification enzyme genes, such as glutathione S-transferases (GSTs), NAD(P)H:quinone oxidoreductase 1 (NQO1), UDP-glucuronyl transferases (UGTs), and heme oxygenase-1 (HO-1), directly via the antioxidant response element (ARE). Recently, many studies have shown that dietary phytochemicals possess cancer chemopreventive potential through the induction of Nrf2-mediated antioxidant/detoxification enzymes and anti-inflammatory signaling pathways to protect organisms against cellular damage caused by oxidative stress. In addition, carcinogenesis can be caused by epigenetic alterations such as DNA methylation and histone modifications in tumor–suppressor genes and oncogenes. Interestingly, recent studies have shown that several naturally occurring dietary phytochemicals can epigenetically modify the chromatin, including reactivating Nrf2 via demethylation of CpG islands and the inhibition of histone deacetylases (HDACs) and/or histone acetyltransferases (HATs). The advancement and development of dietary phytochemicals in cancer chemoprevention research requires the integration of the known, and as-yet-unknown, compounds with the Nrf2-mediated antioxidant, detoxification, and anti-inflammatory systems and their in vitro and in vivo epigenetic mechanisms; human clinical efficacy studies must also be performed.
      datePublished:2012
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      name:Universidad Arturo Prat
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      name:Limin Shu
      affiliation:
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               name:Department of Pharmaceutics, Center for Cancer Prevention Research, Ernest-Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, USA
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      name:Tin Oo Khor
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               type:PostalAddress
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      name:Jong Hun Lee
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            address:
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      name:Francisco Fuentes
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      name:Department of Pharmaceutics, Center for Cancer Prevention Research, Ernest-Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, USA
      name:Department of Pharmaceutics, Center for Cancer Prevention Research, Ernest-Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, USA
      name:Departamento de Agricultura del Desierto y Biotecnología, Universidad Arturo Prat, Iquique, Chile
      name:Department of Pharmaceutics, Center for Cancer Prevention Research, Ernest-Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, USA
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