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Title:
Attenuation of Oxidative Damage to Dna by Tairome and Taurine Analogs | SpringerLink
Description:
Taurine has been suggested to have cytoprotective actions via a number of different mechanisms. The role of taurine in protecting DNA from oxidative damage has received only limited attention. The aim of the present studies was to test the hypothesis that taurine...
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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

,1988, Why is the hydroxyl radical the only that commonly adds to DNA?

Schema {🗺️}

ScholarlyArticle:
      headline:Attenuation of Oxidative Damage to Dna by Tairome and Taurine Analogs
      pageEnd:367
      pageStart:355
      image:https://media.springernature.com/w153/springer-static/cover/book/978-0-306-46838-4.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Taurine 4
         isbn:
            978-0-306-46838-4
            978-0-306-46447-8
         type:Book
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Steve A. Messina
            affiliation:
                  name:University of Florida
                  address:
                     name:Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainvesville
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ralph Dawson
            affiliation:
                  name:University of Florida
                  address:
                     name:Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainvesville
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:High Performance Liquid Chromatography, Oxidative Damage, Amino Acid Analog, Quinone Formation, Base Adduct
      description:Taurine has been suggested to have cytoprotective actions via a number of different mechanisms. The role of taurine in protecting DNA from oxidative damage has received only limited attention. The aim of the present studies was to test the hypothesis that taurine might act to attenuate oxidative damage to DNA caused by free radicals generated by iron-stimulated catecholamine oxidation in the presence of H2O2. Calf thymus DNA (100 μg/tube) was exposed to a reaction mixture containing: ferric chloride (60 μM), H2O2 (2.8 mM) and L-dopa (100 μM).Taurine and taurine analogs were added simultaneously to determine their effects to prevent oxidative damage to DNA. The reaction was carried out for 1 hour at 37° C and terminated by rapid freezing in an ethanol/dry ice bath. The DNA was precipitated with ethanol and subsequently hydrolyzed with formic acid under vacuum. The hydroxylated bases were separated by HPLC and detected electrochemically. All experiments were replicated a minimum of 5 times. Taurine (20 mM) was found to reduce (p〈0.05) damage to DNA as indexed by reductions in the formation of 5-OH-uracil (49%↓)8-OH adenine (37%↓)and 8-OH guanine (21%↓)Taurine had minimal effects to reduce the formation of 5-OH cytosine (〈7%↓) Taurine (20 mM) also increased total DNA recovery after damage 3640% and increased total undamaged guanine -32%. 5-OH Uracil formation could be reduced (p〈0.05) by 1 mM taurine and 8-OH-adenine formation was reduced (p〈0.05) by 5 mM taurine. Studies were conducted with various amino acid analogs and total base adduct formation was reduced by 20 mM β-alanine (30%↓) lysine (58%↓) and glutathione (88%↓) When tested at 20 mM, both hypotaurine and homotaurine provided greater protection against DNA damage than taurine, whereas isethionic acid provided a similar level of protection as taurine. Using identical conditions as the assays for base hydroxylation, we tested whether inhibition of quinone formation could account for taurine's mechanism of action. Taurine (49%↓) homotaurine (24%↓) and hypotaurine (79%↓) all reduced quinone formation. Thus, inhibition of quinone formation could account for part of taurinés mechanism of action to inhibit oxidative damage, but it could not account for homotaurine's greater efficacy in preventing DNA damage. Overall, these studies show that taurine at concentrations normally found in cells can inhibit oxidative damage to DNA.
      datePublished:2002
      isAccessibleForFree:
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         type:WebPageElement
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Book:
      name:Taurine 4
      isbn:
         978-0-306-46838-4
         978-0-306-46447-8
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Florida
      address:
         name:Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainvesville
         type:PostalAddress
      name:University of Florida
      address:
         name:Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainvesville
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Steve A. Messina
      affiliation:
            name:University of Florida
            address:
               name:Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainvesville
               type:PostalAddress
            type:Organization
      name:Ralph Dawson
      affiliation:
            name:University of Florida
            address:
               name:Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainvesville
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainvesville
      name:Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainvesville
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