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Title:
Vitamin C Transport and Its Role in the Central Nervous System | SpringerLink
Description:
Vitamin C, or ascorbic acid, is important as an antioxidant and participates in numerous cellular functions. Although it circulates in plasma in micromolar concentrations, it reaches millimolar concentrations in most tissues. These high ascorbate cellular...
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Schema {🗺️}

ScholarlyArticle:
      headline:Vitamin C Transport and Its Role in the Central Nervous System
      pageEnd:103
      pageStart:85
      image:https://media.springernature.com/w153/springer-static/cover/book/978-94-007-2199-9.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Water Soluble Vitamins
         isbn:
            978-94-007-2199-9
            978-94-007-2198-2
         type:Book
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:James M. May
            affiliation:
                  name:Vanderbilt University School of Medicine
                  address:
                     name:Departments of Medicine and Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Brain, SVCT2, Ascorbate transport, Dehydroascorbate, Neurons, Glutamate
      description:Vitamin C, or ascorbic acid, is important as an antioxidant and participates in numerous cellular functions. Although it circulates in plasma in micromolar concentrations, it reaches millimolar concentrations in most tissues. These high ascorbate cellular concentrations are thought to be generated and maintained by the SVCT2 (Slc23a2), a specific transporter for ascorbate. The vitamin is also readily recycled from its oxidized forms inside cells. Neurons in the central nervous system (CNS) contain some of the highest ascorbic acid concentrations of mammalian tissues. Intracellular ascorbate serves several functions in the CNS, including antioxidant protection, peptide amidation, myelin formation, synaptic potentiation, and protection against glutamate toxicity. The importance of the SVCT2 for CNS function is supported by the finding that its targeted deletion in mice causes widespread cerebral hemorrhage and death on post-natal day 1. Neuronal ascorbate content as maintained by this protein also has relevance for human disease, since ascorbate supplements decrease infarct size in ischemia-reperfusion injury models of stroke, and since ascorbate may protect neurons from the oxidant damage associated with neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s. The aim of this review is to assess the role of the SVCT2 in regulating neuronal ascorbate homeostasis and the extent to which ascorbate affects brain function and antioxidant defenses in the CNS.
      datePublished:2012
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Book:
      name:Water Soluble Vitamins
      isbn:
         978-94-007-2199-9
         978-94-007-2198-2
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Vanderbilt University School of Medicine
      address:
         name:Departments of Medicine and Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, USA
         type:PostalAddress
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      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:James M. May
      affiliation:
            name:Vanderbilt University School of Medicine
            address:
               name:Departments of Medicine and Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Departments of Medicine and Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, USA
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