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Title:
Cell cycle and cell size regulation in Down Syndrome cells | SpringerLink
Description:
Although the neuropathological features typical for Down Syndrome obviously result from deregulation of both, cell cycle control and differentiation processes, so far research focused on the latter. Considering the known similarities between the neuropathology of...
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Topics {✒️}

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Zetterberg A, Larsson O, Wiman KG (1995) What is the restriction point?

Schema {🗺️}

ScholarlyArticle:
      headline:Cell cycle and cell size regulation in Down Syndrome cells
      pageEnd:58
      pageStart:51
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-7091-6721-2.jpg
      genre:
         Medicine
         Medicine (R0)
      isPartOf:
         name:Advances in Down Syndrome Research
         isbn:
            978-3-7091-6721-2
            978-3-211-40776-9
         type:Book
      publisher:
         name:Springer Vienna
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:M. Rosner
            affiliation:
                  name:University of Vienna
                  address:
                     name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:A. Kowalska
            affiliation:
                  name:University of Vienna
                  address:
                     name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:A. Freilinger
            affiliation:
                  name:University of Vienna
                  address:
                     name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:A-R. Prusa
            affiliation:
                  name:University of Vienna
                  address:
                     name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:E. Marton
            affiliation:
                  name:University of Vienna
                  address:
                     name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:M. Hengstschläger
            affiliation:
                  name:University of Vienna
                  address:
                     name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
                     type:PostalAddress
                  type:Organization
                  name:University of Vienna
                  address:
                     name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Down Syndrome, Cell Cycle Control, Cell Cycle Phase, Additional Chromosome, Cell Cycle Activation
      description:Although the neuropathological features typical for Down Syndrome obviously result from deregulation of both, cell cycle control and differentiation processes, so far research focused on the latter. Considering the known similarities between the neuropathology of Down Syndrome and Alzheimer’s disease and the knowledge, that in Alzheimer’s disease neuronal degeneration is associated with the activation of mitogenic signals and cell cycle activation, it is tempting to investigate the consequences of an additional chromosome 21 on mammalian cell cycle regulation. We analysed the distribution of cells in different cell cycle phases on the flowcytometer and the cell size of human amniotic fluid cells with normal karyotypes and with trisomy 21. We could not detect any significant differences suggesting that the presence of an additional copy of the about 225 genes on human chromosome 21 does not trigger cell cycle effects in amniotic fluid cells. These data provide new insights into the cell biology of trisomy 21 cells.
      datePublished:2003
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Book:
      name:Advances in Down Syndrome Research
      isbn:
         978-3-7091-6721-2
         978-3-211-40776-9
Organization:
      name:Springer Vienna
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         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Vienna
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         name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
         type:PostalAddress
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         name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
         type:PostalAddress
      name:University of Vienna
      address:
         name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
         type:PostalAddress
      name:University of Vienna
      address:
         name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
         type:PostalAddress
      name:University of Vienna
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         name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
         type:PostalAddress
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         name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
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ImageObject:
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Person:
      name:M. Rosner
      affiliation:
            name:University of Vienna
            address:
               name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
               type:PostalAddress
            type:Organization
      name:A. Kowalska
      affiliation:
            name:University of Vienna
            address:
               name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
               type:PostalAddress
            type:Organization
      name:A. Freilinger
      affiliation:
            name:University of Vienna
            address:
               name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
               type:PostalAddress
            type:Organization
      name:A-R. Prusa
      affiliation:
            name:University of Vienna
            address:
               name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
               type:PostalAddress
            type:Organization
      name:E. Marton
      affiliation:
            name:University of Vienna
            address:
               name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
               type:PostalAddress
            type:Organization
      name:M. Hengstschläger
      affiliation:
            name:University of Vienna
            address:
               name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
               type:PostalAddress
            type:Organization
            name:University of Vienna
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      name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
      name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
      name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
      name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
      name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
      name:Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Vienna, Austria
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