We are analyzing https://link.springer.com/chapter/10.1007/978-1-4614-8289-5_3.

Title:
Gadd45 Proteins: Key Players of Repair-Mediated DNA Demethylation | SpringerLink
Description:
The three growth arrest and DNA damage 45 (Gadd45) family genes encode for stress-response proteins that are rapidly induced upon cellular stress or differentiation cues. They are well-characterized regulators of cell cycle, senescence, survival, and apoptosis. More...
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Keywords {🔍}

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Topics {✒️}

stress-responsive mtk1/mekk4 mapkkk month download article/chapter cdc2/cyclinb1 kinase inhibitors p53-responsive stress protein dna base-damaging agents p53-regulated protein gadd45 genotoxic-stress-response genes rna-directed dna methylation repair-mediated dna demethylation dna-binding factors shape genotoxic-stress-induced apoptosis dna damage-inducible transcripts negative growth control rna-binding protein required stress-response proteins neuronal activity modifies cell cycle control gene-specific loci privacy choices/manage cookies dna demethylating activity nuclear hormone receptors base excision repair mediated dna demethylation device instant download proteins mediate activation modifies dna accessibility rna binding protein mediating gene activation renewing somatic tissue nucleotide excision repair editor information editors cell cycle checkpoints dna methylation patterns promote dna demethylation stress-inducible gadd45 fornace aj jr replication-dependent loss gadd45 family proteins dna-damage-inducible tet-mediated formation growth-arrest genes active dna demethylation dna repair factors cdna encoding myd118 mll partner tet1 chicken vitellogenin gene promoting dna demethylation methylation-silenced genes genome-wide reprogramming gadd45 gene family

Schema {🗺️}

ScholarlyArticle:
      headline:Gadd45 Proteins: Key Players of Repair-Mediated DNA Demethylation
      pageEnd:50
      pageStart:35
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4614-8289-5.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Gadd45 Stress Sensor Genes
         isbn:
            978-1-4614-8289-5
            978-1-4614-8288-8
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Andrea Schäfer
            affiliation:
                  name:Institute of Molecular Biology
                  address:
                     name:Institute of Molecular Biology, Mainz, Germany
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Proliferate Cell Nuclear Antigen, Xeroderma Pigmentosum, Constitutive Androstane Receptor, Cockayne Syndrome, Mouse Zygote
      description:The three growth arrest and DNA damage 45 (Gadd45) family genes encode for stress-response proteins that are rapidly induced upon cellular stress or differentiation cues. They are well-characterized regulators of cell cycle, senescence, survival, and apoptosis. More recently, it has become clear that Gadd45 proteins promote active DNA demethylation thereby mediating gene activation. This epigenetic function of Gadd45 is important for differentiation and transcriptional regulation during development. Mechanistically, Gadd45 acts as an adapter for DNA repair factors at gene-specific loci to promote removal of 5-methylcytosine from DNA. Hence, Gadd45 is a nexus between DNA repair and epigenetic gene regulation.
      datePublished:2013
      isAccessibleForFree:
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Book:
      name:Gadd45 Stress Sensor Genes
      isbn:
         978-1-4614-8289-5
         978-1-4614-8288-8
Organization:
      name:Springer New York
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Institute of Molecular Biology
      address:
         name:Institute of Molecular Biology, Mainz, Germany
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Andrea Schäfer
      affiliation:
            name:Institute of Molecular Biology
            address:
               name:Institute of Molecular Biology, Mainz, Germany
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Institute of Molecular Biology, Mainz, Germany
WebPageElement:
      isAccessibleForFree:
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