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Targeted Toxins in Cancer Immunotherapy | SpringerLink
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Many anticancer agents are toxic to normal tissues. Thus, the potential to target treatments specifically to tumors would minimize the effects on normal tissues and afford a better safety profile compared to nontargeted treatments. Harnessing immune specificity has...
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Topics {โ๏ธ}
maytansinoid immunoconjugate hun901-n2'-deacetyl-n2' anti-cd22 immunotoxin igg-rfb4-smpt-dga peptide-linked anti-cd30-auristatin conjugates maytansinoid immunoconjugate b-b4-dm1 anti-cd33 antibody-maytansinoid conjugate anti-cd70 antibody-drug conjugates anti-cd19 immunotoxin b43-pap immunotoxins igg-hd37-deglycosylated ricin anti-cd20-auristatin conjugates targeting il-13ralpha2-positive cancer chemotherapy-resistant hairy-cell leukemia anti-cd22-deglycosylated ricin ricin-monoclonal antibody conjugates igg-anti-cd22 immunotoxins carcinoembryonic antigen-positive tumors month download article/chapter anti-cd22-calecheamicin conjugate targeted toxin tf-crm107 replication-competent retroviral vectors ricin a-chain immunotoxins t-cell antigen receptor anti-breast cancer immunotoxin triantennary n-linked oligosaccharides lynch tj jr immunotoxin n901-blocked ricin antibody-mediated targeted delivery recombinant immunotoxin anti-tac multi-mechanistic therapeutic class anticancer carrier-linked prodrugs toxinโrecombinant immunotoxins constructed prostate-specific membrane antigen cd22-targeted cytotoxic immunoconjugate single-chain immunotoxin sgn-10 relapsed cd30-positive lymphomas toxin-based targeted therapy adenoviral vector-based strategies relapsed/refractory b-cell her2-positive breast cancer pretreated b-cell lymphoma b-cell lymphomas resistant small-cell lung cancer monoclonal antibody-ricin single-chain antibody cutaneous t-cell lymphoma cd4+cd25+ human regulatory recurrent b-cell lymphoma vaccine-mediated antitumor immunity prior her2-directed therapy single-chain immunotoxin antibody phage display
Questions {โ}
- Awada A, Bozovic-Spasojevic I, Chow L (2012) New therapies in HER2-positive breast cancer: a major step towards a cure of the disease?
Schema {๐บ๏ธ}
ScholarlyArticle:
headline:Targeted Toxins in Cancer Immunotherapy
pageEnd:396
pageStart:377
image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4614-4732-0.jpg
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Biomedical and Life Sciences
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author:
name:Devalingam Mahalingam
affiliation:
name:University of Texas Health Science Center, Adult Cancer Program, STRF MC8252
address:
name:Cancer Therapy & Research Center, University of Texas Health Science Center, Adult Cancer Program, STRF MC8252, San Antonio, USA
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name:Michael J. Brumlik
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address:
name:SA Scientific, Ltd, San Antonio, USA
type:PostalAddress
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name:Reinhard Waehler
affiliation:
name:Washington University School of Medicine
address:
name:Radiation and Cancer Biology Division, Washington University School of Medicine, St. Louis, USA
type:PostalAddress
type:Organization
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name:David T. Curiel
affiliation:
name:Washington University School of Medicine
address:
name:Radiation and Cancer Biology Division, Washington University School of Medicine, St. Louis, USA
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name:Tyler J. Curiel
affiliation:
name:University of Texas Health Science Center, Adult Cancer Program, STRF MC8252
address:
name:Cancer Therapy & Research Center, University of Texas Health Science Center, Adult Cancer Program, STRF MC8252, San Antonio, USA
type:PostalAddress
type:Organization
type:Person
keywords:Acute Myeloid Leukemia, Anaplastic Large Cell Lymphoma, Gemtuzumab Ozogamicin, Bispecific Antibody, Brentuximab Vedotin
description:Many anticancer agents are toxic to normal tissues. Thus, the potential to target treatments specifically to tumors would minimize the effects on normal tissues and afford a better safety profile compared to nontargeted treatments. Harnessing immune specificity has allowed the successful development of targeted anticancer agents. Successful targeting strategies include antibodies and derivatives, cytokines, peptides, and recombinant viruses. This chapter will summarize the current agents and strategies that exploit immune principles and reagents to develop targeting specificity to treat cancers with maximum sparing of normal tissues.
datePublished:2013
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