We are analyzing https://link.springer.com/chapter/10.1007/978-1-4614-0254-1_9.

Title:
Cancer Stem Cells, Models of Study and Implications of Therapy Resistance Mechanisms | SpringerLink
Description:
There is now compelling evidence for tumour initiating or cancer stem cells (CSCs) in human cancers. The current evidence of this CSC hypothesis, the CSC phenotype and methods of identification, culture and in vitro modelling will be presented, with an emphasis on...
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Topics {✒️}

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Questions {❓}

Baud V, Karin M (2009) Is NF-kappaB a good target for cancer therapy?
Gupta PB, Chaffer CL, Weinberg RA (2009) Cancer stem cells: mirage or reality?
Jordan CT (2009) Cancer stem cells: controversial or just misunderstood?
Maitland NJ et al (2010) Gene transfer vectors targeted to human prostate cancer: do we need better preclinical testing systems?
Maitland NJ et al (2010) Prostate cancer stem cells: Do they have a basal or luminal phenotype?
Maitland NJ, Collins AT (2010) Cancer stem cells – a therapeutic target?
Wang Y, Armstrong SA (2008) Cancer: inappropriate expression of stem cell programs?

Schema {🗺️}

ScholarlyArticle:
      headline:Cancer Stem Cells, Models of Study and Implications of Therapy Resistance Mechanisms
      pageEnd:118
      pageStart:105
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4614-0254-1.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Human Cell Transformation
         isbn:
            978-1-4614-0254-1
            978-1-4614-0253-4
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Fiona M. Frame
            affiliation:
                  name:University of York
                  address:
                     name:Department of Biology, YCR Cancer Research Unit, University of York, Heslington, UK
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Norman J. Maitland
            affiliation:
                  name:University of York
                  address:
                     name:YCR Cancer Research Unit, Department of Biology, University of York, Heslington, UK
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Stem Cell, Prostate Cancer, Androgen Receptor, Cancer Stem Cell, Luminal Cell
      description:There is now compelling evidence for tumour initiating or cancer stem cells (CSCs) in human cancers. The current evidence of this CSC hypothesis, the CSC phenotype and methods of identification, culture and in vitro modelling will be presented, with an emphasis on prostate cancer. Inherent in the CSC hypothesis is their dual role, as a tumour-initiating cell, and as a source of treatment-resistant cells; the mechanisms behind therapeutic resistance will be discussed. Such resistance is a consequence of the unique CSC phenotype, which differs from the differentiated progeny, which make up the bulk of a tumour. It seems that to target the whole tumour, employing traditional therapies to target bulk populations alongside targeted CSC-specific drugs, provides the best hope of lasting treatment or even cure.
      datePublished:2011
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Book:
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      isbn:
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         978-1-4614-0253-4
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      name:Springer New York
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         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of York
      address:
         name:Department of Biology, YCR Cancer Research Unit, University of York, Heslington, UK
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      name:University of York
      address:
         name:YCR Cancer Research Unit, Department of Biology, University of York, Heslington, UK
         type:PostalAddress
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      name:Fiona M. Frame
      affiliation:
            name:University of York
            address:
               name:Department of Biology, YCR Cancer Research Unit, University of York, Heslington, UK
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Norman J. Maitland
      affiliation:
            name:University of York
            address:
               name:YCR Cancer Research Unit, Department of Biology, University of York, Heslington, UK
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Biology, YCR Cancer Research Unit, University of York, Heslington, UK
      name:YCR Cancer Research Unit, Department of Biology, University of York, Heslington, UK
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