We are analyzing https://link.springer.com/chapter/10.1007/82_2011_142.

Title:
Roles of Lineage-Determining Transcription Factors in Establishing Open Chromatin: Lessons From High-Throughput Studies | SpringerLink
Description:
The interpretation of the regulatory information of the genome by sequence-specific transcription factors lies at the heart of the specification of cellular identity and function. While most cells in a complex metazoan organism express hundreds of such transcription...
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Keywords {🔍}

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Topics {✒️}

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Schema {🗺️}

ScholarlyArticle:
      headline:Roles of Lineage-Determining Transcription Factors in Establishing Open Chromatin: Lessons From High-Throughput Studies
      pageEnd:15
      pageStart:1
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-642-24103-1.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Epigenetic Regulation of Lymphocyte Development
         isbn:
            978-3-642-24103-1
            978-3-642-24102-4
         type:Book
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Sven Heinz
            affiliation:
                  name:University of California, San Diego
                  address:
                     name:Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Christopher K. Glass
            affiliation:
                  name:University of California, San Diego
                  address:
                     name:Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Open Chromatin, Histone H3K4, Ternary Complex Formation, Histone Modification Pattern, Transcription Factor Motif
      description:The interpretation of the regulatory information of the genome by sequence-specific transcription factors lies at the heart of the specification of cellular identity and function. While most cells in a complex metazoan organism express hundreds of such transcription factors, the underlying mechanisms by which they ultimately achieve their functional locations within different cell types remain poorly understood. Here, we contrast various models of how cell type-specific binding patterns may arise using available evidence from ChIP-Seq experiments obtained in tractable developmental model systems, particularly the hematopoietic system. The data suggests a model whereby relatively small sets of lineage-determining transcription factors jointly compete with nucleosomes to establish their cell type-specific binding patterns. These binding sites gain histone marks indicative of active cis-regulatory elements and define a large fraction of the enhancer-like regions differentiated cell types. The formation of these regions of open chromatin enables the recruitment of secondary transcription factors that contribute additional transcription regulatory functionality required for the cell type-appropriate expression of genes with both general and specialized cellular functions.
      datePublished:2011
      isAccessibleForFree:
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Book:
      name:Epigenetic Regulation of Lymphocyte Development
      isbn:
         978-3-642-24103-1
         978-3-642-24102-4
Organization:
      name:Springer Berlin Heidelberg
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of California, San Diego
      address:
         name:Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, USA
         type:PostalAddress
      name:University of California, San Diego
      address:
         name:Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, USA
         type:PostalAddress
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      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Sven Heinz
      affiliation:
            name:University of California, San Diego
            address:
               name:Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, USA
               type:PostalAddress
            type:Organization
      name:Christopher K. Glass
      affiliation:
            name:University of California, San Diego
            address:
               name:Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, USA
      name:Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, USA
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