We are analyzing https://link.springer.com/article/10.1007/s40291-016-0202-7.

Title:
Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases | Molecular Diagnosis & Therapy
Description:
Curcumin is a bioactive polyphenol occurring in the rhizomes of Curcuma longa. It is well-reputed for its chemopreventive and anticancer properties; however, recent evidence has revealed numerous biological and pharmacological effects of curcumin that are relevant to the treatment of non-cancer diseases. Mechanistically, curcumin exerts its pharmacological effects through anti-inflammatory and antioxidant mechanisms via interaction with different signaling molecules and transcription factors. In addition, epigenetic modulators such as microRNAs (miRs) have emerged as novel targets of curcumin. Curcumin was found to modulate the expression of several pathogenic miRs in brain, ocular, renal, and liver diseases. The present systematic review was conducted to identify miRs that are regulated by curcumin in non-cancer diseases.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure if the website is profiting.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Link.springer.com might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

pubmed, google, scholar, article, cas, curcumin, central, sahebkar, res, disease, micrornas, expression, effects, research, curcuma, longa, cancer, biochem, med, microrna, randomized, trial, curcuminoids, pharmacol, human, diseases, biol, wang, yang, diabetic, clinical, cell, phytother, rats, nature, alzheimers, review, brain, liver, regulation, activity, cells, panahi, food, lukiw, university, noncancer, turmeric, rev, controlled,

Topics {✒️}

nf-kb-sensitive mirna-125b anti-tau cochaperone bag2 month download article/chapter genistein modulates nf-κb haloperidol-induced orofacial dyskinesia maciej banach ros-generating metal sulfates nf-κb-dependent induction hiv-1gp120 v3 loop ameliorates diabetic nephropathy age-related macular degeneration enhances β-catenin signaling diabetic nephropathy role apoe deficient mice experimental diabetic nephropathy short-term curcuminoid supplementation systemic oxidative stress full article pdf targets casein kinase-1α lipid-lowering effects placebo-controlled trial bioavailability-boosted curcuminoids micro-rna abundance common micro rnas nanotechnology research center specific micro rna author reply e7 podocytic adhesion damage target complement factor randomized controlled trial mouse liver regeneration privacy choices/manage cookies blood glucose level fructose-fed rats randomized controlled trials pogue ai diabetic nephropathy lipopolysaccharide induced rats human arpe-19 cells author information authors article momtazi sulfur mustard intoxication amirhossein sahebkar declare microrna-mediated control randomized crossover trial common human diseases matrix metalloproteinase expression differential gene expression glutamate-induced excitotoxicity mediates endothelial recruitment

Questions {❓}

Are curcuminoids effective C-reactive protein-lowering agents in clinical practice?
Autophagic activation: a key piece of the puzzle for the curcumin-associated cognitive enhancement?
Why it is necessary to translate curcumin into clinical practice for the prevention and treatment of metabolic syndrome?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases
         description:Curcumin is a bioactive polyphenol occurring in the rhizomes of Curcuma longa. It is well-reputed for its chemopreventive and anticancer properties; however, recent evidence has revealed numerous biological and pharmacological effects of curcumin that are relevant to the treatment of non-cancer diseases. Mechanistically, curcumin exerts its pharmacological effects through anti-inflammatory and antioxidant mechanisms via interaction with different signaling molecules and transcription factors. In addition, epigenetic modulators such as microRNAs (miRs) have emerged as novel targets of curcumin. Curcumin was found to modulate the expression of several pathogenic miRs in brain, ocular, renal, and liver diseases. The present systematic review was conducted to identify miRs that are regulated by curcumin in non-cancer diseases.
         datePublished:2016-05-30T00:00:00Z
         dateModified:2016-05-30T00:00:00Z
         pageStart:335
         pageEnd:345
         sameAs:https://doi.org/10.1007/s40291-016-0202-7
         keywords:
            Curcumin
            Diabetic Nephropathy
            Curcuma Longa
            APOE Knockout Mouse
            PTP1B Expression
            Molecular Medicine
            Human Genetics
            Cancer Research
            Laboratory Medicine
            Pharmacotherapy
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs40291-016-0202-7/MediaObjects/40291_2016_202_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs40291-016-0202-7/MediaObjects/40291_2016_202_Fig2_HTML.gif
         isPartOf:
            name:Molecular Diagnosis & Therapy
            issn:
               1179-2000
               1177-1062
            volumeNumber:20
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer International Publishing
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Amir Abbas Momtazi
               affiliation:
                     name:Mashhad University of Medical Sciences
                     address:
                        name:Student Research Committee, Department of Medical Biotechnology, Nanotechnology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Giuseppe Derosa
               affiliation:
                     name:University of Pavia
                     address:
                        name:Center for the Study of Endocrine-Metabolic Pathophysiology and Clinical Research, University of Pavia, Pavia, Italy
                        type:PostalAddress
                     type:Organization
                     name:University of Pavia and Fondazione IRCCS Policlinico S. Matteo
                     address:
                        name:Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Pamela Maffioli
               affiliation:
                     name:University of Pavia and Fondazione IRCCS Policlinico S. Matteo
                     address:
                        name:Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Maciej Banach
               affiliation:
                     name:Medical University of Lodz
                     address:
                        name:Department of Hypertension, Medical University of Lodz, Lodz, Poland
                        type:PostalAddress
                     type:Organization
                     name:Medical University of Lodz
                     address:
                        name:Healthy Aging Research Centre (HARC), Medical University of Lodz, Lodz, Poland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Amirhossein Sahebkar
               affiliation:
                     name:Mashhad University of Medical Sciences
                     address:
                        name:Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
                        type:PostalAddress
                     type:Organization
                     name:University of Western Australia
                     address:
                        name:Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases
      description:Curcumin is a bioactive polyphenol occurring in the rhizomes of Curcuma longa. It is well-reputed for its chemopreventive and anticancer properties; however, recent evidence has revealed numerous biological and pharmacological effects of curcumin that are relevant to the treatment of non-cancer diseases. Mechanistically, curcumin exerts its pharmacological effects through anti-inflammatory and antioxidant mechanisms via interaction with different signaling molecules and transcription factors. In addition, epigenetic modulators such as microRNAs (miRs) have emerged as novel targets of curcumin. Curcumin was found to modulate the expression of several pathogenic miRs in brain, ocular, renal, and liver diseases. The present systematic review was conducted to identify miRs that are regulated by curcumin in non-cancer diseases.
      datePublished:2016-05-30T00:00:00Z
      dateModified:2016-05-30T00:00:00Z
      pageStart:335
      pageEnd:345
      sameAs:https://doi.org/10.1007/s40291-016-0202-7
      keywords:
         Curcumin
         Diabetic Nephropathy
         Curcuma Longa
         APOE Knockout Mouse
         PTP1B Expression
         Molecular Medicine
         Human Genetics
         Cancer Research
         Laboratory Medicine
         Pharmacotherapy
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs40291-016-0202-7/MediaObjects/40291_2016_202_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs40291-016-0202-7/MediaObjects/40291_2016_202_Fig2_HTML.gif
      isPartOf:
         name:Molecular Diagnosis & Therapy
         issn:
            1179-2000
            1177-1062
         volumeNumber:20
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Amir Abbas Momtazi
            affiliation:
                  name:Mashhad University of Medical Sciences
                  address:
                     name:Student Research Committee, Department of Medical Biotechnology, Nanotechnology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Giuseppe Derosa
            affiliation:
                  name:University of Pavia
                  address:
                     name:Center for the Study of Endocrine-Metabolic Pathophysiology and Clinical Research, University of Pavia, Pavia, Italy
                     type:PostalAddress
                  type:Organization
                  name:University of Pavia and Fondazione IRCCS Policlinico S. Matteo
                  address:
                     name:Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Pamela Maffioli
            affiliation:
                  name:University of Pavia and Fondazione IRCCS Policlinico S. Matteo
                  address:
                     name:Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Maciej Banach
            affiliation:
                  name:Medical University of Lodz
                  address:
                     name:Department of Hypertension, Medical University of Lodz, Lodz, Poland
                     type:PostalAddress
                  type:Organization
                  name:Medical University of Lodz
                  address:
                     name:Healthy Aging Research Centre (HARC), Medical University of Lodz, Lodz, Poland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Amirhossein Sahebkar
            affiliation:
                  name:Mashhad University of Medical Sciences
                  address:
                     name:Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
                     type:PostalAddress
                  type:Organization
                  name:University of Western Australia
                  address:
                     name:Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Molecular Diagnosis & Therapy
      issn:
         1179-2000
         1177-1062
      volumeNumber:20
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Mashhad University of Medical Sciences
      address:
         name:Student Research Committee, Department of Medical Biotechnology, Nanotechnology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
         type:PostalAddress
      name:University of Pavia
      address:
         name:Center for the Study of Endocrine-Metabolic Pathophysiology and Clinical Research, University of Pavia, Pavia, Italy
         type:PostalAddress
      name:University of Pavia and Fondazione IRCCS Policlinico S. Matteo
      address:
         name:Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy
         type:PostalAddress
      name:University of Pavia and Fondazione IRCCS Policlinico S. Matteo
      address:
         name:Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy
         type:PostalAddress
      name:Medical University of Lodz
      address:
         name:Department of Hypertension, Medical University of Lodz, Lodz, Poland
         type:PostalAddress
      name:Medical University of Lodz
      address:
         name:Healthy Aging Research Centre (HARC), Medical University of Lodz, Lodz, Poland
         type:PostalAddress
      name:Mashhad University of Medical Sciences
      address:
         name:Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
         type:PostalAddress
      name:University of Western Australia
      address:
         name:Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Amir Abbas Momtazi
      affiliation:
            name:Mashhad University of Medical Sciences
            address:
               name:Student Research Committee, Department of Medical Biotechnology, Nanotechnology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
               type:PostalAddress
            type:Organization
      name:Giuseppe Derosa
      affiliation:
            name:University of Pavia
            address:
               name:Center for the Study of Endocrine-Metabolic Pathophysiology and Clinical Research, University of Pavia, Pavia, Italy
               type:PostalAddress
            type:Organization
            name:University of Pavia and Fondazione IRCCS Policlinico S. Matteo
            address:
               name:Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy
               type:PostalAddress
            type:Organization
      name:Pamela Maffioli
      affiliation:
            name:University of Pavia and Fondazione IRCCS Policlinico S. Matteo
            address:
               name:Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy
               type:PostalAddress
            type:Organization
      name:Maciej Banach
      affiliation:
            name:Medical University of Lodz
            address:
               name:Department of Hypertension, Medical University of Lodz, Lodz, Poland
               type:PostalAddress
            type:Organization
            name:Medical University of Lodz
            address:
               name:Healthy Aging Research Centre (HARC), Medical University of Lodz, Lodz, Poland
               type:PostalAddress
            type:Organization
      name:Amirhossein Sahebkar
      affiliation:
            name:Mashhad University of Medical Sciences
            address:
               name:Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
               type:PostalAddress
            type:Organization
            name:University of Western Australia
            address:
               name:Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Student Research Committee, Department of Medical Biotechnology, Nanotechnology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
      name:Center for the Study of Endocrine-Metabolic Pathophysiology and Clinical Research, University of Pavia, Pavia, Italy
      name:Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy
      name:Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy
      name:Department of Hypertension, Medical University of Lodz, Lodz, Poland
      name:Healthy Aging Research Centre (HARC), Medical University of Lodz, Lodz, Poland
      name:Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
      name:Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(382)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Knockout.js
Prism.js

CDN Services {📦}

Crossref

4.29s.

LINK . SPRINGER . COM {}