We are analyzing https://link.springer.com/article/10.1007/s13402-024-00960-8.

Title:
A systematic review on the culture methods and applications of 3D tumoroids for cancer research and personalized medicine | Cellular Oncology
Description:
Cancer is a highly heterogeneous disease, and thus treatment responses vary greatly between patients. To improve therapy efficacy and outcome for cancer patients, more representative and patient-specific preclinical models are needed. Organoids and tumoroids are 3D cell culture models that typically retain the genetic and epigenetic characteristics, as well as the morphology, of their tissue of origin. Thus, they can be used to understand the underlying mechanisms of cancer initiation, progression, and metastasis in a more physiological setting. Additionally, co-culture methods of tumoroids and cancer-associated cells can help to understand the interplay between a tumor and its tumor microenvironment. In recent years, tumoroids have already helped to refine treatments and to identify new targets for cancer therapy. Advanced culturing systems such as chip-based fluidic devices and bioprinting methods in combination with tumoroids have been used for high-throughput applications for personalized medicine. Even though organoid and tumoroid models are complex in vitro systems, validation of results in vivo is still the common practice. Here, we describe how both animal- and human-derived tumoroids have helped to identify novel vulnerabilities for cancer treatment in recent years, and how they are currently used for precision medicine.
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Keywords {🔍}

pubmed, cancer, article, google, scholar, cas, cell, organoids, central, tumor, cells, models, tumoroids, drug, organoid, model, httpsdoiorgs, human, patientderived, treatment, response, research, culture, nat, tumoroid, tissue, patients, coculture, heterogeneity, medicine, therapy, pdts, stem, tme, screening, vivo, types, primary, personalized, vitro, modeling, lines, systems, study, wang, immune, lung, disease, cultures, colorectal,

Topics {✒️}

gov/bill/117th-congress/senate-bill/5002/ cdh3-β-catenin-laminin signaling axis gov/ccg/research/functional-genomics/hcmi ionizing-radiation-induced intestinal injury pd-1/pd-l1 inhibitors article google scholar patient-specific immune-enhanced organoids air–liquid interface promotes patient-derived organoid-fibroblast model cyclodextrin-lgk974 inclusion complexes patient-derived organoid pharmacotyping patient-derived organoid serves ultra-high-throughput screening thiol-reactive organoid barcoding cre recombinase-based system single-cell transcriptomic profiles generating patient-derived gliomas ovarian cancer-specific genes patient-derived xenograft models establishing patient-derived organoids patient-specific preclinical models patient-derived pancreatic cancer multi-organ chip-based systems patient-derived organoid models patient-derived tumor antigen multiparametric microscopy-based readout xenograft-derived tumoroid screen patient-specific precision medicine proving inter-patient heterogeneity orthotopic patient-derived xenograft muscle-invasive bladder cancer providing high-level feedback patient-derived cancer organoids human-derived 3d models patient-specific drug responses confirmed lineage-dependent differences high-throughput drug screens patient-derived lung tumoroids reversibly dormant basal-luminal patient-specific colonoscopy images jak/stat inflammatory signaling air-liquid interface patient-derived cell lines wnt-induced phenotypic switch patient-derived spheroid cultures chip-based fluidic devices patient-derived tumor organoids testing patient-specific responses differential pre-malignant programs high-grade glioma organoids

Questions {❓}

Straume, Are 90% of deaths from cancer caused by metastases?

Schema {🗺️}

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         Biomedicine
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