We are analyzing https://link.springer.com/article/10.1007/s13205-023-03863-x.

Title:
LncRNA BCRT1 depletion suppresses cervical cancer cell growth via sponging miR-432-5p/CCR7 axis | 3 Biotech
Description:
Breast cancer-related transcript 1 (BCRT1), a lncRNA that is overexpressed in several human cancers, facilitates the progression of breast cancer and osteosarcoma. Nevertheless, the function of BCRT1 in cervical cancer (CC) still remains unknown. In this study, BCRT1 was significantly overexpressed in CC tissues and correlated with the advanced stage of CC patients. BCRT1 depletion dampened CC cell proliferation, and drives cell apoptosis and cell cycle inhibition. Mechanistically, BCRT1 bound miR-432-5p and negatively modulated miR-432-5p’s expression in CC cells. Reduced miR-452-3p expression was observed in CC tissues and exerted tumor suppressive function in CC cell growth. Further mechanism study revealed that CCR7 was clarified as a target of miR-432-5p and was inhibited following BCRT1 depletion. CCR7 transfection could recover CC cell growth that was suppressed with BCRT1 down-regulation. These results revealed the novel function of BCRT1/miR-432-5p/CCR7 pathway in CC, suggesting BCRT1 might be a potential biomarker and target for CC treatment.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Telecommunications

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure if the website is profiting.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Link.springer.com could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

article, cancer, pubmed, google, scholar, cas, cervical, cell, noncoding, bcrt, long, central, shanxi, rna, wang, breast, mirp, microrna, medical, hospital, growth, axis, yang, expression, ccr, rnas, biology, targeting, privacy, cookies, content, data, lncrna, sponging, progression, access, nature, med, invasion, rev, function, information, publish, search, depletion, author, mol, res, zhao, zhang,

Topics {✒️}

circfkbp8/mir-432-5p/e2f7 cascade functions sponging mir-432-5p/ccr7 axis mir-193a-5p/pin1 signaling bcrt1/mir-432-5p/ccr7 pathway mir-432-5p/e2f6 axis month download article/chapter sponging mir-20a-5p bcrt1 bound mir-432-5p long noncoding rna negatively modulated mir-432-5p microrna-432-5p regulates sprouting regulating mir-1303/fgf7 axis hpv-negative cervical cancer reduced mir-452-3p expression targeting mir-1303/ptbp3 axis regulating mir-432–5p/mcl1 cc cell growth lncrna-mediated regulation sponging mir-138-5p sponging mir-942-5p full article pdf bcrt1 depletion competitive endogenous rna writing-original draft targeting mir-432-5p privacy choices/manage cookies cell cycle inhibition metastatic cervical cancer coding rnas mirnas drives cell apoptosis western medicine hospital related subjects article wang accepted manuscript version shanxi medical university xiangdong bai holds exclusive rights shanxi province european economic area upregulating macc1 expression lymph node metastasis davalos-misslitz ac synthetic microrna biology endogenous microrna sponges genome-wide approaches circ-cep128 enhances mir-432-5p cell signaling conditions privacy policy jiefang south road

Schema {🗺️}

WebPage:
      mainEntity:
         headline:LncRNA BCRT1 depletion suppresses cervical cancer cell growth via sponging miR-432-5p/CCR7 axis
         description:Breast cancer-related transcript 1 (BCRT1), a lncRNA that is overexpressed in several human cancers, facilitates the progression of breast cancer and osteosarcoma. Nevertheless, the function of BCRT1 in cervical cancer (CC) still remains unknown. In this study, BCRT1 was significantly overexpressed in CC tissues and correlated with the advanced stage of CC patients. BCRT1 depletion dampened CC cell proliferation, and drives cell apoptosis and cell cycle inhibition. Mechanistically, BCRT1 bound miR-432-5p and negatively modulated miR-432-5p’s expression in CC cells. Reduced miR-452-3p expression was observed in CC tissues and exerted tumor suppressive function in CC cell growth. Further mechanism study revealed that CCR7 was clarified as a target of miR-432-5p and was inhibited following BCRT1 depletion. CCR7 transfection could recover CC cell growth that was suppressed with BCRT1 down-regulation. These results revealed the novel function of BCRT1/miR-432-5p/CCR7 pathway in CC, suggesting BCRT1 might be a potential biomarker and target for CC treatment.
         datePublished:2023-12-19T00:00:00Z
         dateModified:2023-12-19T00:00:00Z
         pageStart:1
         pageEnd:9
         sameAs:https://doi.org/10.1007/s13205-023-03863-x
         keywords:
            BCRT1
            miR-432-5p
            CCR7
            Cervical cancer
            Biotechnology
            Agriculture
            Cancer Research
            Bioinformatics
            Stem Cells
            Biomaterials
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13205-023-03863-x/MediaObjects/13205_2023_3863_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13205-023-03863-x/MediaObjects/13205_2023_3863_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13205-023-03863-x/MediaObjects/13205_2023_3863_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13205-023-03863-x/MediaObjects/13205_2023_3863_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13205-023-03863-x/MediaObjects/13205_2023_3863_Fig5_HTML.png
         isPartOf:
            name:3 Biotech
            issn:
               2190-5738
               2190-572X
            volumeNumber:14
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer International Publishing
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Xiaoli Wang
               affiliation:
                     name:Shanxi Medical University
                     address:
                        name:Department of Gynaecology, Shanxi Integrated Traditional Chinese and Western Medicine Hospital, Shanxi Medical University, Taiyuan, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Huifang Li
               affiliation:
                     name:Shanxi Medical University
                     address:
                        name:Department of Gynaecology, Shanxi Integrated Traditional Chinese and Western Medicine Hospital, Shanxi Medical University, Taiyuan, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Naihua Li
               affiliation:
                     name:Shanxi Medical University
                     address:
                        name:Department of Gynaecology, Shanxi Integrated Traditional Chinese and Western Medicine Hospital, Shanxi Medical University, Taiyuan, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hailan Yang
               affiliation:
                     name:The First Hospital of Shanxi Medical University
                     address:
                        name:Department of Gynaecology, Shanxi Medical University, The First Hospital of Shanxi Medical University, Taiyuan, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Xiangdong Bai
               url:http://orcid.org/0000-0002-0980-2515
               affiliation:
                     name:Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University
                     address:
                        name:Department of Breast Surgery, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:LncRNA BCRT1 depletion suppresses cervical cancer cell growth via sponging miR-432-5p/CCR7 axis
      description:Breast cancer-related transcript 1 (BCRT1), a lncRNA that is overexpressed in several human cancers, facilitates the progression of breast cancer and osteosarcoma. Nevertheless, the function of BCRT1 in cervical cancer (CC) still remains unknown. In this study, BCRT1 was significantly overexpressed in CC tissues and correlated with the advanced stage of CC patients. BCRT1 depletion dampened CC cell proliferation, and drives cell apoptosis and cell cycle inhibition. Mechanistically, BCRT1 bound miR-432-5p and negatively modulated miR-432-5p’s expression in CC cells. Reduced miR-452-3p expression was observed in CC tissues and exerted tumor suppressive function in CC cell growth. Further mechanism study revealed that CCR7 was clarified as a target of miR-432-5p and was inhibited following BCRT1 depletion. CCR7 transfection could recover CC cell growth that was suppressed with BCRT1 down-regulation. These results revealed the novel function of BCRT1/miR-432-5p/CCR7 pathway in CC, suggesting BCRT1 might be a potential biomarker and target for CC treatment.
      datePublished:2023-12-19T00:00:00Z
      dateModified:2023-12-19T00:00:00Z
      pageStart:1
      pageEnd:9
      sameAs:https://doi.org/10.1007/s13205-023-03863-x
      keywords:
         BCRT1
         miR-432-5p
         CCR7
         Cervical cancer
         Biotechnology
         Agriculture
         Cancer Research
         Bioinformatics
         Stem Cells
         Biomaterials
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13205-023-03863-x/MediaObjects/13205_2023_3863_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13205-023-03863-x/MediaObjects/13205_2023_3863_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13205-023-03863-x/MediaObjects/13205_2023_3863_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13205-023-03863-x/MediaObjects/13205_2023_3863_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13205-023-03863-x/MediaObjects/13205_2023_3863_Fig5_HTML.png
      isPartOf:
         name:3 Biotech
         issn:
            2190-5738
            2190-572X
         volumeNumber:14
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Xiaoli Wang
            affiliation:
                  name:Shanxi Medical University
                  address:
                     name:Department of Gynaecology, Shanxi Integrated Traditional Chinese and Western Medicine Hospital, Shanxi Medical University, Taiyuan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Huifang Li
            affiliation:
                  name:Shanxi Medical University
                  address:
                     name:Department of Gynaecology, Shanxi Integrated Traditional Chinese and Western Medicine Hospital, Shanxi Medical University, Taiyuan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Naihua Li
            affiliation:
                  name:Shanxi Medical University
                  address:
                     name:Department of Gynaecology, Shanxi Integrated Traditional Chinese and Western Medicine Hospital, Shanxi Medical University, Taiyuan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hailan Yang
            affiliation:
                  name:The First Hospital of Shanxi Medical University
                  address:
                     name:Department of Gynaecology, Shanxi Medical University, The First Hospital of Shanxi Medical University, Taiyuan, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Xiangdong Bai
            url:http://orcid.org/0000-0002-0980-2515
            affiliation:
                  name:Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University
                  address:
                     name:Department of Breast Surgery, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:3 Biotech
      issn:
         2190-5738
         2190-572X
      volumeNumber:14
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Shanxi Medical University
      address:
         name:Department of Gynaecology, Shanxi Integrated Traditional Chinese and Western Medicine Hospital, Shanxi Medical University, Taiyuan, China
         type:PostalAddress
      name:Shanxi Medical University
      address:
         name:Department of Gynaecology, Shanxi Integrated Traditional Chinese and Western Medicine Hospital, Shanxi Medical University, Taiyuan, China
         type:PostalAddress
      name:Shanxi Medical University
      address:
         name:Department of Gynaecology, Shanxi Integrated Traditional Chinese and Western Medicine Hospital, Shanxi Medical University, Taiyuan, China
         type:PostalAddress
      name:The First Hospital of Shanxi Medical University
      address:
         name:Department of Gynaecology, Shanxi Medical University, The First Hospital of Shanxi Medical University, Taiyuan, China
         type:PostalAddress
      name:Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University
      address:
         name:Department of Breast Surgery, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Xiaoli Wang
      affiliation:
            name:Shanxi Medical University
            address:
               name:Department of Gynaecology, Shanxi Integrated Traditional Chinese and Western Medicine Hospital, Shanxi Medical University, Taiyuan, China
               type:PostalAddress
            type:Organization
      name:Huifang Li
      affiliation:
            name:Shanxi Medical University
            address:
               name:Department of Gynaecology, Shanxi Integrated Traditional Chinese and Western Medicine Hospital, Shanxi Medical University, Taiyuan, China
               type:PostalAddress
            type:Organization
      name:Naihua Li
      affiliation:
            name:Shanxi Medical University
            address:
               name:Department of Gynaecology, Shanxi Integrated Traditional Chinese and Western Medicine Hospital, Shanxi Medical University, Taiyuan, China
               type:PostalAddress
            type:Organization
      name:Hailan Yang
      affiliation:
            name:The First Hospital of Shanxi Medical University
            address:
               name:Department of Gynaecology, Shanxi Medical University, The First Hospital of Shanxi Medical University, Taiyuan, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Xiangdong Bai
      url:http://orcid.org/0000-0002-0980-2515
      affiliation:
            name:Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University
            address:
               name:Department of Breast Surgery, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Gynaecology, Shanxi Integrated Traditional Chinese and Western Medicine Hospital, Shanxi Medical University, Taiyuan, China
      name:Department of Gynaecology, Shanxi Integrated Traditional Chinese and Western Medicine Hospital, Shanxi Medical University, Taiyuan, China
      name:Department of Gynaecology, Shanxi Integrated Traditional Chinese and Western Medicine Hospital, Shanxi Medical University, Taiyuan, China
      name:Department of Gynaecology, Shanxi Medical University, The First Hospital of Shanxi Medical University, Taiyuan, China
      name:Department of Breast Surgery, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(142)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

4.15s.

LINK . SPRINGER . COM {}