We are analyzing https://link.springer.com/article/10.1007/s12672-013-0131-4.

Title:
Interplay Between Genomic Alterations and Androgen Receptor Signaling During Prostate Cancer Development and Progression | Discover Oncology
Description:
Advanced prostate cancer (PCa) treated with androgen deprivation therapy (ADT) eventually relapses to an ADT-resistant disease referred to as castration-resistant PCa (CRPC). Recent integrative analyses of PCa genomes have led to the elucidation of potential subtypes that are revelatory to the development of PCa as well as the mechanisms of resistance to ADT and CRPC progression. These studies have confirmed that alterations in the androgen receptor (AR) signaling axis are central to CRPC progression, and have uncovered complex mechanisms by which AR and other components of the AR signaling axis affect, and are affected by, genomic changes and epigenetic transformations. Among the most frequent alterations in CRPC are direct alterations in the AR gene. These AR gene alterations include AR amplification, point mutations, and more recently AR gene rearrangements leading to expression of truncated, constitutively active AR splice variants that are impervious to ADT. In this review, we will highlight genomic alterations that are important for development and progression of PCa, with a focus on how these alterations affect, and are affected by, activity of the AR signaling axis.
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Keywords {🔍}

cancer, pca, article, google, scholar, pubmed, variants, androgen, prostate, cas, gene, truncated, crpc, cell, receptor, expression, alterations, genomic, cells, signaling, progression, rearrangements, fulllength, splice, resistance, activity, binding, exons, studies, splicing, variant, mutations, occur, genes, ets, copy, number, role, line, nuclear, levels, subtypes, transcriptional, events, genome, erg, res, therapy, adt, mechanisms,

Topics {✒️}

drive androgen-independent growth enhancer-driven lineage-specific transcription require dht/ar-mediated recruitment androgen-independent prostate cancer androgen-dependent subline derived castration-resistant prostate cancer tmprss2–erg rearrangement-positive cancers castration-recurrent prostate cancer dna-directed enzymatic activities require full-length ar androgen-independent growth tmprss2-erg gene fusions speckle-type poz protein androgen deprivation therapy irradiation-induced dna damage h3k4-specific histone methyltransferase androgen/ar signaling axis ar-driven enhancer element castrate-recurrent prostate cancer spink1-positive prostate cancer late-passage lncap cells activation-induced cytidine deaminase cwr-r1 cell line cul3-based ubiquitin ligase ar-v7 variant encoded hormone-dependent cancer full-length ar expression full-length ar activity duplication-positive cells coincided cwr-r1 xenografts grown genome-wide copy number ar-v7 overexpression arises cwr-r1 cell lines androgen receptor signaling signal-dependent proteolysis human androgen receptor adt-resistant disease referred median ar-v7 expression ets family fusions viable therapeutic target androgen-independent function active transcription driven line ar-targeted therapies androgen receptor mutations create chromatin environments androgen receptor mutation constitutively active forms metastatic prostate cancer therapeutic targets downstream activate oncogenic signaling

Questions {❓}

These integrative and whole-genome sequencing studies have raised an intriguing question: why is there a propensity towards structural alteration in the PCa genome?

Schema {🗺️}

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         headline:Interplay Between Genomic Alterations and Androgen Receptor Signaling During Prostate Cancer Development and Progression
         description:Advanced prostate cancer (PCa) treated with androgen deprivation therapy (ADT) eventually relapses to an ADT-resistant disease referred to as castration-resistant PCa (CRPC). Recent integrative analyses of PCa genomes have led to the elucidation of potential subtypes that are revelatory to the development of PCa as well as the mechanisms of resistance to ADT and CRPC progression. These studies have confirmed that alterations in the androgen receptor (AR) signaling axis are central to CRPC progression, and have uncovered complex mechanisms by which AR and other components of the AR signaling axis affect, and are affected by, genomic changes and epigenetic transformations. Among the most frequent alterations in CRPC are direct alterations in the AR gene. These AR gene alterations include AR amplification, point mutations, and more recently AR gene rearrangements leading to expression of truncated, constitutively active AR splice variants that are impervious to ADT. In this review, we will highlight genomic alterations that are important for development and progression of PCa, with a focus on how these alterations affect, and are affected by, activity of the AR signaling axis.
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            Enzalutamide
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            Oncology
            Cancer Research
            Surgical Oncology
            Molecular Medicine
            Radiotherapy
            Internal Medicine
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      headline:Interplay Between Genomic Alterations and Androgen Receptor Signaling During Prostate Cancer Development and Progression
      description:Advanced prostate cancer (PCa) treated with androgen deprivation therapy (ADT) eventually relapses to an ADT-resistant disease referred to as castration-resistant PCa (CRPC). Recent integrative analyses of PCa genomes have led to the elucidation of potential subtypes that are revelatory to the development of PCa as well as the mechanisms of resistance to ADT and CRPC progression. These studies have confirmed that alterations in the androgen receptor (AR) signaling axis are central to CRPC progression, and have uncovered complex mechanisms by which AR and other components of the AR signaling axis affect, and are affected by, genomic changes and epigenetic transformations. Among the most frequent alterations in CRPC are direct alterations in the AR gene. These AR gene alterations include AR amplification, point mutations, and more recently AR gene rearrangements leading to expression of truncated, constitutively active AR splice variants that are impervious to ADT. In this review, we will highlight genomic alterations that are important for development and progression of PCa, with a focus on how these alterations affect, and are affected by, activity of the AR signaling axis.
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         Androgen Deprivation Therapy
         Abiraterone
         Enzalutamide
         Androgen Receptor Gene
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         Cancer Research
         Surgical Oncology
         Molecular Medicine
         Radiotherapy
         Internal Medicine
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