We are analyzing https://link.springer.com/article/10.1007/s12539-019-00347-6.

Title:
A Systems Biology Roadmap to Decode mTOR Control System in Cancer | Interdisciplinary Sciences: Computational Life Sciences
Description:
Mechanistic target of rapamycin (mTOR) is a critical protein in the regulation of cell fate decision making, especially in cancer cells. mTOR acts as a signal integrator and is one of the main elements of interactions among the pivotal cellular processes such as cell death, autophagy, metabolic reprogramming, cell growth, and cell cycle. The temporal control of these processes is essential for the cellular homeostasis and dysregulation of mTOR signaling pathway results in different phenotypes, including aging, oncogenesis, cell survival, cell growth, senescence, quiescence, and cell death. In this paper, we have proposed a systems biology roadmap to study mTOR control system, which introduces the theoretical and experimental modalities to decode temporal and dynamical characteristics of mTOR signaling in cancer.
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Keywords {🔍}

pubmed, article, google, scholar, cas, central, mtor, cell, cancer, autophagy, signaling, biol, nat, rev, tavassoly, cells, systems, mol, biology, signalling, wang, network, control, aging, sabatini, modeling, sciences, rapamycin, growth, sci, tyson, dynamic, nature, regulation, disease, clarke, med, inhibitors, mammalian, plos, circadian, privacy, cookies, content, analysis, research, life, dorvash, target, protein,

Topics {✒️}

month download article/chapter targeting pi3k/akt/mtor signaling tunable biological oscillations reduced mtor signalling article interdisciplinary sciences adenosine monosphosphate-dependent kinase tgf-β-induced activation mtor complex1–s6k1 signaling systems biology roadmap systems biology primer full article pdf nutrient signalling assessing atrial-selective pharmacology gene regulatory networks autophagy/translation switch based network-based approach conditions privacy policy article dorvash oestrogen signalling related subjects martinez-lemus la dynamic network model biochemical reaction networks systems therapeutics analyses discrete modeling approach dalle pezze gene network modeling privacy choices/manage cookies dynamic response concept signalling crosstalk systems biology pivotal cellular processes blagosklonny mv mathematical modeling autophagy-dependent cell death aging stem cells central hub mtor signaling network tsc-mtor pathway negative feedback loops check access instant access cell fate breast cancer cells boolean network simulations article log anti-aging therapeutics unfolded protein response proliferating cells unmasks colorectal cancer cells

Questions {❓}

Janku F, Yap TA, Meric-Bernstam F (2018) Targeting the PI3K pathway in cancer: are we making headway?
Ma D, Li S, Molusky MM, Lin JD (2012) Circadian autophagy rhythm: a link between clock and metabolism?

Schema {🗺️}

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         Statistics for Life Sciences
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         Theoretical and Computational Chemistry
         Theoretical
         Mathematical and Computational Physics
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