We are analyzing https://link.springer.com/article/10.1007/s12519-019-00229-3.

Title:
Immunological pathogenesis and treatment of systemic lupus erythematosus | World Journal of Pediatrics
Description:
Background Systemic lupus erythematosis (SLE) is a complex and clinically heterogeneous autoimmune disease. A variety of immunological defects contribute to SLE, including dysregulated innate and adaptive immune response. A clearer understanding of the mechanisms driving disease pathogenesis combined with recent advances in medical science is predicted to enable accelerated progress towards improved SLE-personalized approaches to treatment. The aim of this review was to clarify the immunological pathogenesis and treatment of SLE. Data sources Literature reviews and original research articles were collected from database, including PubMed and Wanfang. Relevant articles about SLE were included. Results Breakdown of self-tolerance is the main pathogenesis of SLE. The innate and adaptive immune networks are interlinked with each other through cytokines, complements, immune complexes and kinases of the intracellular machinery. Treatments targeted at possible targets of immunity have been assessed in clinical trials. Most of them did not show better safety and efficacy than traditional treatments. However, novel targeting treatments are still being explored. Conclusions Dysregulated immune response plays a critical role in SLE, including innate immunity and adaptive immunity. Biologic agents that aim to specifically target abnormal immune processes were assessing and may bring new hope to SLE patients.
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Keywords {🔍}

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Topics {✒️}

nacht leucine-rich-repeat protein/absent lupus-prone mrl/lpr mice organ-specific autoimmune diseases si-rui yang b-cell stimulating factor tumour necrosis factor-alpha anti-cd123 monoclonal antibodies t-cell-dependent antigen [59] treat b-cell lymphomas chimeric anti-cd20 antibody bcr b-cell receptor akt-gsk3beta signaling pathway anti-cd40l monoclonal antibodies anti-ifn monoclonal antibodies article download pdf anti-ds-dna concentrations bcl b-cell lymphoma full access stimulator-mediated signaling pathway improved sle-personalized approaches erm ezrin/radixin/moesin mei-ping lu cell-dependent inflammatory responses chemokine receptor cxcr3 reducing ds-dna levels interferon-alpha/beta system ubiquitin-mediated cellular functions induce b-cell proliferation enhancing tfh-cell responses systemic autoimmune diseases human–mouse chimeric mab activation-induced cell surface intensive short-term treatment neutrophil extracellular trap inhibits b-cell survival helper-cell subset assisting steroidal anti-inflammatory drugs b-targeted agents b-cell receptor receptor tyrosine kinase promotes b-cell activation neutrophil extracellular traps continuously produce ifn-α b-cell lymphoma 6 open label study zap-70 zeta-chain nzb/nzw mice active autoantibody-positive sle party related directly systemic lupus erythematosus

Schema {🗺️}

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         headline:Immunological pathogenesis and treatment of systemic lupus erythematosus
         description:Systemic lupus erythematosis (SLE) is a complex and clinically heterogeneous autoimmune disease. A variety of immunological defects contribute to SLE, including dysregulated innate and adaptive immune response. A clearer understanding of the mechanisms driving disease pathogenesis combined with recent advances in medical science is predicted to enable accelerated progress towards improved SLE-personalized approaches to treatment. The aim of this review was to clarify the immunological pathogenesis and treatment of SLE. Literature reviews and original research articles were collected from database, including PubMed and Wanfang. Relevant articles about SLE were included. Breakdown of self-tolerance is the main pathogenesis of SLE. The innate and adaptive immune networks are interlinked with each other through cytokines, complements, immune complexes and kinases of the intracellular machinery. Treatments targeted at possible targets of immunity have been assessed in clinical trials. Most of them did not show better safety and efficacy than traditional treatments. However, novel targeting treatments are still being explored. Dysregulated immune response plays a critical role in SLE, including innate immunity and adaptive immunity. Biologic agents that aim to specifically target abnormal immune processes were assessing and may bring new hope to SLE patients.
         datePublished:2019-02-22T00:00:00Z
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      headline:Immunological pathogenesis and treatment of systemic lupus erythematosus
      description:Systemic lupus erythematosis (SLE) is a complex and clinically heterogeneous autoimmune disease. A variety of immunological defects contribute to SLE, including dysregulated innate and adaptive immune response. A clearer understanding of the mechanisms driving disease pathogenesis combined with recent advances in medical science is predicted to enable accelerated progress towards improved SLE-personalized approaches to treatment. The aim of this review was to clarify the immunological pathogenesis and treatment of SLE. Literature reviews and original research articles were collected from database, including PubMed and Wanfang. Relevant articles about SLE were included. Breakdown of self-tolerance is the main pathogenesis of SLE. The innate and adaptive immune networks are interlinked with each other through cytokines, complements, immune complexes and kinases of the intracellular machinery. Treatments targeted at possible targets of immunity have been assessed in clinical trials. Most of them did not show better safety and efficacy than traditional treatments. However, novel targeting treatments are still being explored. Dysregulated immune response plays a critical role in SLE, including innate immunity and adaptive immunity. Biologic agents that aim to specifically target abnormal immune processes were assessing and may bring new hope to SLE patients.
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