We are analyzing https://link.springer.com/article/10.1007/s12185-011-0776-0.

Title:
Ribosome defects in disorders of erythropoiesis | International Journal of Hematology
Description:
Over the past decade, genetic lesions that cause ribosome dysfunction have been identified in both congenital and acquired human disorders. These discoveries have established a new category of disorders, known as ribosomopathies, in which the primary pathophysiology is related to impaired ribosome function. The protoptypical disorders are Diamond–Blackfan anemia, a congenital bone marrow failure syndrome, and the 5q- syndrome, a subtype of myelodysplastic syndrome. In both of these disorders, impaired ribosome function causes a severe macrocytic anemia. In this review, we will discuss the evidence that defects in ribosomal biogenesis cause the hematologic phenotype of Diamond–Blackfan anemia and the 5q- syndrome. We will also explore the potential mechanisms by which a ribosomal defect, which would be expected to have widespread consequences, may lead to specific defects in erythropoiesis.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,642,828 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't see how the site brings in money.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

article, google, scholar, pubmed, cas, ribosomal, protein, anemia, diamondblackfan, syndrome, cell, blood, rps, ribosome, ebert, gene, mol, genet, biol, disorders, erythropoiesis, narla, hum, function, defects, benjamin, human, nat, model, genes, usa, privacy, cookies, content, journal, bone, marrow, failure, myelodysplastic, biogenesis, access, mutated, deficiency, cells, activation, mdm, publish, research, search, anupama,

Topics {✒️}

month download article/chapter rpl11-translation-dependent mechanism p53-dependent checkpoint response p53-mediated dark skin diamond–blackfan anemia results mdm2-mediated p53 ubiquitination diamond–blackfan anemia patients distinct haematological disorder article international journal diamond–blackfan anaemia full article pdf treacher collins syndrome bone marrow failure ribosomal protein s19 privacy choices/manage cookies karp research building diamond–blackfan anemia severe macrocytic anemia ribosomal protein l23 ribosomal protein l11 ribosomal protein s6 5q- syndrome gene harvard medical school p53 protein family ribosomal protein l5 ribosomal protein rps24 ribosomal protein s7 ribosomal protein l26 trends biochem sci p53–mdm2 interaction article narla 40s ribosomal subunits myelodysplastic syndrome ribosomal protein genes mol cell biol biochem cell biol translation-related genes cd34+ cells generated ebert bl human 5q- syndrome ribosomal protein required european economic area dominant negative effect van den berghe world health organization post-transcriptional steps aguissa-toure ah idol ra symmetrical congenital notches jones nc

Questions {❓}

How common are extraribosomal functions of ribosomal proteins?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Ribosome defects in disorders of erythropoiesis
         description:Over the past decade, genetic lesions that cause ribosome dysfunction have been identified in both congenital and acquired human disorders. These discoveries have established a new category of disorders, known as ribosomopathies, in which the primary pathophysiology is related to impaired ribosome function. The protoptypical disorders are Diamond–Blackfan anemia, a congenital bone marrow failure syndrome, and the 5q- syndrome, a subtype of myelodysplastic syndrome. In both of these disorders, impaired ribosome function causes a severe macrocytic anemia. In this review, we will discuss the evidence that defects in ribosomal biogenesis cause the hematologic phenotype of Diamond–Blackfan anemia and the 5q- syndrome. We will also explore the potential mechanisms by which a ribosomal defect, which would be expected to have widespread consequences, may lead to specific defects in erythropoiesis.
         datePublished:2011-02-01T00:00:00Z
         dateModified:2011-02-01T00:00:00Z
         pageStart:144
         pageEnd:149
         sameAs:https://doi.org/10.1007/s12185-011-0776-0
         keywords:
            Myelodysplastic syndrome
            Diamond–Blackfan anemia
            p53
            Hematology
            Oncology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12185-011-0776-0/MediaObjects/12185_2011_776_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12185-011-0776-0/MediaObjects/12185_2011_776_Fig2_HTML.gif
         isPartOf:
            name:International Journal of Hematology
            issn:
               1865-3774
               0925-5710
            volumeNumber:93
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Japan
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Anupama Narla
               affiliation:
                     name:Harvard Medical School
                     address:
                        name:Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Children’s Hospital Boston
                     address:
                        name:Department of Medicine, Children’s Hospital Boston, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Slater N. Hurst
               affiliation:
                     name:Harvard Medical School
                     address:
                        name:Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Benjamin L. Ebert
               affiliation:
                     name:Harvard Medical School
                     address:
                        name:Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Harvard Stem Cell Institute
                     address:
                        name:Harvard Stem Cell Institute, Cambridge, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Ribosome defects in disorders of erythropoiesis
      description:Over the past decade, genetic lesions that cause ribosome dysfunction have been identified in both congenital and acquired human disorders. These discoveries have established a new category of disorders, known as ribosomopathies, in which the primary pathophysiology is related to impaired ribosome function. The protoptypical disorders are Diamond–Blackfan anemia, a congenital bone marrow failure syndrome, and the 5q- syndrome, a subtype of myelodysplastic syndrome. In both of these disorders, impaired ribosome function causes a severe macrocytic anemia. In this review, we will discuss the evidence that defects in ribosomal biogenesis cause the hematologic phenotype of Diamond–Blackfan anemia and the 5q- syndrome. We will also explore the potential mechanisms by which a ribosomal defect, which would be expected to have widespread consequences, may lead to specific defects in erythropoiesis.
      datePublished:2011-02-01T00:00:00Z
      dateModified:2011-02-01T00:00:00Z
      pageStart:144
      pageEnd:149
      sameAs:https://doi.org/10.1007/s12185-011-0776-0
      keywords:
         Myelodysplastic syndrome
         Diamond–Blackfan anemia
         p53
         Hematology
         Oncology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12185-011-0776-0/MediaObjects/12185_2011_776_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12185-011-0776-0/MediaObjects/12185_2011_776_Fig2_HTML.gif
      isPartOf:
         name:International Journal of Hematology
         issn:
            1865-3774
            0925-5710
         volumeNumber:93
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Japan
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Anupama Narla
            affiliation:
                  name:Harvard Medical School
                  address:
                     name:Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Harvard Medical School
                  address:
                     name:Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Children’s Hospital Boston
                  address:
                     name:Department of Medicine, Children’s Hospital Boston, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Slater N. Hurst
            affiliation:
                  name:Harvard Medical School
                  address:
                     name:Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Benjamin L. Ebert
            affiliation:
                  name:Harvard Medical School
                  address:
                     name:Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Harvard Medical School
                  address:
                     name:Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Harvard Stem Cell Institute
                  address:
                     name:Harvard Stem Cell Institute, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:International Journal of Hematology
      issn:
         1865-3774
         0925-5710
      volumeNumber:93
Organization:
      name:Springer Japan
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Harvard Medical School
      address:
         name:Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Children’s Hospital Boston
      address:
         name:Department of Medicine, Children’s Hospital Boston, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Harvard Stem Cell Institute
      address:
         name:Harvard Stem Cell Institute, Cambridge, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Anupama Narla
      affiliation:
            name:Harvard Medical School
            address:
               name:Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
            name:Children’s Hospital Boston
            address:
               name:Department of Medicine, Children’s Hospital Boston, Boston, USA
               type:PostalAddress
            type:Organization
      name:Slater N. Hurst
      affiliation:
            name:Harvard Medical School
            address:
               name:Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Benjamin L. Ebert
      affiliation:
            name:Harvard Medical School
            address:
               name:Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Stem Cell Institute
            address:
               name:Harvard Stem Cell Institute, Cambridge, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
      name:Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
      name:Department of Medicine, Children’s Hospital Boston, Boston, USA
      name:Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
      name:Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
      name:Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
      name:Harvard Stem Cell Institute, Cambridge, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(174)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

5.04s.

LINK . SPRINGER . COM {}