We are analyzing https://link.springer.com/article/10.1007/s11912-012-0249-5.

Title:
Driver Mutations in Melanoma: Lessons Learned From Bench-to-Bedside Studies | Current Oncology Reports
Description:
The identification of somatic driver mutations in human samples has allowed for the development of a molecular classification for melanoma. Recent breakthroughs in the treatment of metastatic melanoma have arisen as a result of these significant new insights into the molecular biology of the disease, particularly the development of inhibitors of activating BRAFV600E mutations. In this article the roles of several mutations known to be involved in the malignant transformation of melanocytes are reviewed including BRAF, PTEN, NRAS, ckit, and p16 as well as some of the emerging mutations in cutaneous and uveal melanoma. The bench to bedside collaborations that resulted in these discoveries are summarized, and potential therapeutic strategies to target driver mutations in specific patient subsets are discussed.
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Keywords {🔍}

google, scholar, melanoma, article, cancer, mutations, braf, res, cell, nras, clin, metastatic, mutation, human, pten, uveal, malignant, therapeutic, nature, oncol, cutaneous, dermatol, melanomas, med, patients, invest, somatic, target, gene, primary, phase, pubmed, kluger, molecular, ckit, potential, access, survival, tumor, trial, nat, clinical, frequent, imatinib, privacy, cookies, content, studies, mehnert, inhibitor,

Topics {✒️}

stem cell factor/c-kit proto-oncogene c-kit expression high-dose imatinib mesylate month download article/chapter c-kit-dependent growth kit kinase-domain mutation oncogene-defined taxonomy leads c-kit receptor article google scholar pten-akt3 signaling cascade activated c-met placebo-controlled study nras-mutated human melanomas privacy choices/manage cookies somatic driver mutations full article pdf related subjects comparative histologic features activated n-rasq61k ap-2 transcription factor gene encoding brca1 target driver mutations genomics references papers lentigo maligna subtypes melanoma cell lines identify inactivating mutations genes chromosomes cancer natl cancer inst mmac1/pten gene independent prognostic factor neural system tumors mutations occur early potential therapeutic strategies tumor cell proliferation gene expression studies european economic area specific patient subsets ink4a-deficient background differentially impact prognosis bassett rl jr pi3k effector pathways ink4a/arf interactions genotype-phenotype relationships asco education booklet pten deficiency cooperates potential therapeutic response n-ras upregulation human lung cancer multikinase inhibitor sorafenib potential therapeutic target

Questions {❓}

Chemotherapy and biologic therapies for melanoma: do they work?
C-Kit-dependent growth of uveal melanoma cells: a potential therapeutic target?

Schema {🗺️}

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         description:The identification of somatic driver mutations in human samples has allowed for the development of a molecular classification for melanoma. Recent breakthroughs in the treatment of metastatic melanoma have arisen as a result of these significant new insights into the molecular biology of the disease, particularly the development of inhibitors of activating BRAFV600E mutations. In this article the roles of several mutations known to be involved in the malignant transformation of melanocytes are reviewed including BRAF, PTEN, NRAS, ckit, and p16 as well as some of the emerging mutations in cutaneous and uveal melanoma. The bench to bedside collaborations that resulted in these discoveries are summarized, and potential therapeutic strategies to target driver mutations in specific patient subsets are discussed.
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