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Keywords {🔍}

article, google, scholar, cas, cancer, luteolin, cell, cells, human, activity, glioblastoma, processing, heat, effect, food, content, chem, ghedira, apoptosis, research, antioxidant, flavonoid, flavonoids, lee, gueder, chaaban, ioannou, chekir, luis, migration, angiogenesis, thermal, invasion, quercetin, glioma, res, wang, privacy, cookies, data, dorra, maatouk, potential, access, breast, ghoul, agric, information, publish, search,

Topics {✒️}

measure tgf-β-induced invasion month download article/chapter caspase-calpain-dependent pathways metal-catalyzed oxidative degradation colon carcinoma cells dorra el gueder supratentorial low-grade gliomas lower anti-tumor potential article environmental science human glioblastoma cells u87 glioblastoma cells glioblastoma cells u87 pollution research aims leila chekir ghedira inhibit cell adhesion breast cancer cells inhibit cell migration glioblastoma cell viability full article pdf cancer cell apoptosis privacy choices/manage cookies institut de neurophysiopathologie national polytechnics institute endothelial cell angiogenesis ros/er stress cell cycle blockage cell cycle arrest related subjects low-grade gliomas zaineb daouefi �ministère tunisienne de poly-l-lysine malignant melanoma cells aqueous model systems growth inhibitory effects histone deacetylase activity pancreatic tumor cells cell invasion heat treated luteolin european economic area modified boyden chambers capillary network formation results obtained show serine protease inhibitor interphase microtubule dynamics epithelial-mesenchymal transition lorraine ensaia-inpl anti-tumor activity anticancer res 22 tunis el manar

Questions {❓}

• Hartmann C, Hentschel B, Tatagiba M, Schramm J, Schnell O, Seidel C, Stein R, Reifenberger G, Pietsch T, von Deimling A (2011) Molecular markers in low-grade gliomas: predictive or prognostic?

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         headline:Heat processing effect of luteolin on anti-metastasis activity of human glioblastoma cells U87
         description:Among the flavonoïds, luteolin is a flavone that has been identified in many plants. It is known for its apoptotic potential with damage to DNA and cell cycle blockage. Many studies have shown that luteolin has anti-oxidant, anti-inflammatory, and anti-cancer activities. However, it is known that heat treatment (boiling, cooking, and treating with microwaves …) can influence the structure of flavonoïds, which often leads to changes in their activities. The present study was conducted to study the effect of heated luteolin on anti-tumor activity of glioblastoma cells U87. Glioblastoma cell viability was evaluated by MTT assay. Adhesion assay was performed on different protein matrices (collagen type 1, vitronectin, fibronectin, and poly-L-lysine); migration assay was determined by modified Boyden chambers and videomicroscopy, and finally, angiogenesis was tested in vitro by capillary network formation on Matrigel™. The results obtained show that the thermal treatment significantly reduces its cytotoxic activity and ability to inhibit cell adhesion to different protein matrices. It was also found that the heat processed significantly reduced the ability of luteolin to inhibit cell migration, cell invasion, and endothelial cell angiogenesis (HMEC-1). This suggests that heat treated luteolin has a lower anti-tumor potential than native luteolin.
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      description:Among the flavonoïds, luteolin is a flavone that has been identified in many plants. It is known for its apoptotic potential with damage to DNA and cell cycle blockage. Many studies have shown that luteolin has anti-oxidant, anti-inflammatory, and anti-cancer activities. However, it is known that heat treatment (boiling, cooking, and treating with microwaves …) can influence the structure of flavonoïds, which often leads to changes in their activities. The present study was conducted to study the effect of heated luteolin on anti-tumor activity of glioblastoma cells U87. Glioblastoma cell viability was evaluated by MTT assay. Adhesion assay was performed on different protein matrices (collagen type 1, vitronectin, fibronectin, and poly-L-lysine); migration assay was determined by modified Boyden chambers and videomicroscopy, and finally, angiogenesis was tested in vitro by capillary network formation on Matrigel™. The results obtained show that the thermal treatment significantly reduces its cytotoxic activity and ability to inhibit cell adhesion to different protein matrices. It was also found that the heat processed significantly reduced the ability of luteolin to inhibit cell migration, cell invasion, and endothelial cell angiogenesis (HMEC-1). This suggests that heat treated luteolin has a lower anti-tumor potential than native luteolin.
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