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month download article/chapter high-grade malignant glioma extracellular membrane-proximal domain il-6/stat3 survival signaling normal human brain cd147-targeting sirna inhibits kaplan–meier analysis showed related subjects promoting tumor growth full article pdf cell surface inducer glioblastoma cell line matrix metalloproteinase induction matrix metalloproteinase modulator author information authors privacy choices/manage cookies newly diagnosed glioblastoma molecular markers assess subsequent prognosis epithelio-stromal interactions human glioblastoma multiforme modulate malignant properties significant prognostic marker dietrich py epithelial ovarian cancer primary glioblastoma recurrence prostate cancer progression poor prognostic marker produce matrix metalloproteinases immunohistochemistry assay salivary duct carcinoma integrated genomic analysis independent prognostic marker european economic area beta-strand swapping monoclonal antibody 12c3 bi xc short-term survivors neuro-oncology aims conditions privacy policy article yang 1007/s11060-013-1102 check access instant access zhong wd diaz la jr liang wang article journal hab18g/cd147 binds glutamine synthetase expression

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         headline:Prognostic significance of CD147 in patients with glioblastoma
         description:CD147, also known as extracellular matrix metalloproteinase inducer, is a widely distributed cell surface glycoprotein that belongs to the immunoglobulin superfamily. CD147 has been proved to be enriched on the surface of many tumor cells, promoting tumor growth, invasion and metastasis by its stimulation effect on adjacent fibroblasts to produce matrix metalloproteinases. In this study, we aimed to explore the expression pattern of CD147 in glioblastoma (GBM) and investigate whether it could be used to assess subsequent prognosis of patients. For that, we recruited a total of 206 patients with pathologically confirmed GBM and 36 normal control brain tissue specimens. The expression of CD147 in GBM and normal tissues was investigated by immunohistochemistry assay. Genetic factors including MGMT and IDH1 mutation were also investigated to justify the prognostic significance of CD147. Results showed that CD147 expression was increased in GBM compared with that in normal tissues. Kaplan–Meier analysis showed that increased CD147 expression was associated with poor overall survival of patients with GBM. Moreover, Cox’s proportional hazards model revealed that CD147 expression was an independent and significant prognostic marker of overall survival in GBM patients. These results proved that CD147 expression was relatively abundant in GBM and can be potentially used to predict prognosis and treatment response in GBM patients.
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            Glioblastoma
            Immunohistochemistry
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      headline:Prognostic significance of CD147 in patients with glioblastoma
      description:CD147, also known as extracellular matrix metalloproteinase inducer, is a widely distributed cell surface glycoprotein that belongs to the immunoglobulin superfamily. CD147 has been proved to be enriched on the surface of many tumor cells, promoting tumor growth, invasion and metastasis by its stimulation effect on adjacent fibroblasts to produce matrix metalloproteinases. In this study, we aimed to explore the expression pattern of CD147 in glioblastoma (GBM) and investigate whether it could be used to assess subsequent prognosis of patients. For that, we recruited a total of 206 patients with pathologically confirmed GBM and 36 normal control brain tissue specimens. The expression of CD147 in GBM and normal tissues was investigated by immunohistochemistry assay. Genetic factors including MGMT and IDH1 mutation were also investigated to justify the prognostic significance of CD147. Results showed that CD147 expression was increased in GBM compared with that in normal tissues. Kaplan–Meier analysis showed that increased CD147 expression was associated with poor overall survival of patients with GBM. Moreover, Cox’s proportional hazards model revealed that CD147 expression was an independent and significant prognostic marker of overall survival in GBM patients. These results proved that CD147 expression was relatively abundant in GBM and can be potentially used to predict prognosis and treatment response in GBM patients.
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         Immunohistochemistry
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