We are analyzing https://link.springer.com/article/10.1007/s11033-019-05057-2.

Title:
Expression of selected miRNA, RARβ and FHIT genes in BALf of squamous cell lung cancer (squamous-cell carcinoma, SCC) patients: a pilot study | Molecular Biology Reports
Description:
Two suppressor genes which often undergo epigenetic silencing during the early stages of lung carcinogenesis are those encoding retinoic acid receptor-β (RARβ) and Fhit protein (FHIT). RARβ expression is regulated by miRNA-34a and miRNA-141, and FHIT expression by miRNA-143 and miRNA-217. The aim of the study was to assess how selected miRNAs regulate the expression of their targeted genes in bronchoalveolar lavage fluid (BALf), obtained from patients with SCC of the lung. It also examines the relationship between the genetic findings and the clinical and pathomorphological features of the tumor. A total of 50 BALf samples were taken: 25 from patients with SCC and 25 from healthy donors. The expression (RQ) of the selected genes was analyzed by qPCR, as well as the miRNA level, with a particular emphasis on the relationship between the expression of the genes themselves and their corresponding miRNAs; in addition, the expression of the genes and miRNAs were compared with the pathomorphological features of the tumor and the clinical features of patients. Analysis of the RQ values showed downregulation of RARß, FHIT and miRNA-34a and increased expression of miRNA-141, miRNA-143 and miRNA-217 in all BALf samples (P > 0.05). No correlation was found between the expression of the selected genes and corresponding miRNAs, history of smoking, cancer stage, age and sex of the patients. The presence of the selected genes and miRNAs in BALf material does not seem to have diagnostic potential in patients with SCC; however, the results should be verified on a larger group of patients.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't see how the site brings in money.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

lung, expression, cancer, mirna, fhit, patients, article, scc, study, balf, mirnas, google, scholar, genes, cell, cas, gene, rarβ, tumor, diagnostic, studies, nsclc, analysis, molecular, material, present, clinical, found, group, table, selected, samples, development, microrna, test, protein, results, role, lodz, rna, data, squamous, fluid, genetic, level, values, rarß, loss, poland, patient,

Topics {✒️}

paired macroscopically-unchanged tissues real-time pcr small-cell lung cancer small-cell lung carcinoma mann–whitney u-test u-mann–whitney test catalogue numbers fhit—hs00179987_m1 article download pdf squamous-cell carcinoma squamous cell carcinoma statistically significant relationships national research committee privacy choices/manage cookies domańska-senderowska full access binds retinoic acid gene promoter methylation tissue cell type lung cancer diagnosis protein products play including lung cancer lung cancer—quantification low cell amount retinoic acid receptors gene expression requires tumour suppressor gene shapiro–wilk test kruskal–wallis test prostate cancer risk routine diagnostic due primary lung tumors written informed consent main content log 5-year survival rate term “genetic landscape fragile histidine triad biologically- active form chest x-ray β-actvb adjusted procedure frequently appeared individualized therapeutic tools ethics declarations conflict individual participants included advanced lung cancer cell lines scc histologic subtype bronchoalveolar lavage fluid multiple group comparisons tumor suppressor gene preneoplastic bronchial lesions

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Expression of selected miRNA, RARβ and FHIT genes in BALf of squamous cell lung cancer (squamous-cell carcinoma, SCC) patients: a pilot study
         description:Two suppressor genes which often undergo epigenetic silencing during the early stages of lung carcinogenesis are those encoding retinoic acid receptor-β (RARβ) and Fhit protein (FHIT). RARβ expression is regulated by miRNA-34a and miRNA-141, and FHIT expression by miRNA-143 and miRNA-217. The aim of the study was to assess how selected miRNAs regulate the expression of their targeted genes in bronchoalveolar lavage fluid (BALf), obtained from patients with SCC of the lung. It also examines the relationship between the genetic findings and the clinical and pathomorphological features of the tumor. A total of 50 BALf samples were taken: 25 from patients with SCC and 25 from healthy donors. The expression (RQ) of the selected genes was analyzed by qPCR, as well as the miRNA level, with a particular emphasis on the relationship between the expression of the genes themselves and their corresponding miRNAs; in addition, the expression of the genes and miRNAs were compared with the pathomorphological features of the tumor and the clinical features of patients. Analysis of the RQ values showed downregulation of RARß, FHIT and miRNA-34a and increased expression of miRNA-141, miRNA-143 and miRNA-217 in all BALf samples (P > 0.05). No correlation was found between the expression of the selected genes and corresponding miRNAs, history of smoking, cancer stage, age and sex of the patients. The presence of the selected genes and miRNAs in BALf material does not seem to have diagnostic potential in patients with SCC; however, the results should be verified on a larger group of patients.
         datePublished:2019-09-09T00:00:00Z
         dateModified:2019-09-09T00:00:00Z
         pageStart:6593
         pageEnd:6597
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1007/s11033-019-05057-2
         keywords:
            miRNA
            FHIT
            RARbeta
            Lung cancer
            Squamous cell lung cancer
            Animal Biochemistry
            Animal Anatomy / Morphology / Histology
         image:
         isPartOf:
            name:Molecular Biology Reports
            issn:
               1573-4978
               0301-4851
            volumeNumber:46
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Netherlands
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Agata Dutkowska
               url:http://orcid.org/0000-0003-3882-979X
               affiliation:
                     name:Medical University of Lodz
                     address:
                        name:Department of General and Oncological Pulmonology, Medical University of Lodz, Lodz, Poland
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Adam Antczak
               affiliation:
                     name:Medical University of Lodz
                     address:
                        name:Department of General and Oncological Pulmonology, Medical University of Lodz, Lodz, Poland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Daria Domańska-Senderowska
               affiliation:
                     name:Medical University of Lodz
                     address:
                        name:Department of Molecular Bases of Medicine, Medical University of Lodz, Lodz, Poland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ewa Brzeziańska-Lasota
               affiliation:
                     name:Medical University of Lodz
                     address:
                        name:Department of Molecular Bases of Medicine, Medical University of Lodz, Lodz, Poland
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Expression of selected miRNA, RARβ and FHIT genes in BALf of squamous cell lung cancer (squamous-cell carcinoma, SCC) patients: a pilot study
      description:Two suppressor genes which often undergo epigenetic silencing during the early stages of lung carcinogenesis are those encoding retinoic acid receptor-β (RARβ) and Fhit protein (FHIT). RARβ expression is regulated by miRNA-34a and miRNA-141, and FHIT expression by miRNA-143 and miRNA-217. The aim of the study was to assess how selected miRNAs regulate the expression of their targeted genes in bronchoalveolar lavage fluid (BALf), obtained from patients with SCC of the lung. It also examines the relationship between the genetic findings and the clinical and pathomorphological features of the tumor. A total of 50 BALf samples were taken: 25 from patients with SCC and 25 from healthy donors. The expression (RQ) of the selected genes was analyzed by qPCR, as well as the miRNA level, with a particular emphasis on the relationship between the expression of the genes themselves and their corresponding miRNAs; in addition, the expression of the genes and miRNAs were compared with the pathomorphological features of the tumor and the clinical features of patients. Analysis of the RQ values showed downregulation of RARß, FHIT and miRNA-34a and increased expression of miRNA-141, miRNA-143 and miRNA-217 in all BALf samples (P > 0.05). No correlation was found between the expression of the selected genes and corresponding miRNAs, history of smoking, cancer stage, age and sex of the patients. The presence of the selected genes and miRNAs in BALf material does not seem to have diagnostic potential in patients with SCC; however, the results should be verified on a larger group of patients.
      datePublished:2019-09-09T00:00:00Z
      dateModified:2019-09-09T00:00:00Z
      pageStart:6593
      pageEnd:6597
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1007/s11033-019-05057-2
      keywords:
         miRNA
         FHIT
         RARbeta
         Lung cancer
         Squamous cell lung cancer
         Animal Biochemistry
         Animal Anatomy / Morphology / Histology
      image:
      isPartOf:
         name:Molecular Biology Reports
         issn:
            1573-4978
            0301-4851
         volumeNumber:46
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Agata Dutkowska
            url:http://orcid.org/0000-0003-3882-979X
            affiliation:
                  name:Medical University of Lodz
                  address:
                     name:Department of General and Oncological Pulmonology, Medical University of Lodz, Lodz, Poland
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Adam Antczak
            affiliation:
                  name:Medical University of Lodz
                  address:
                     name:Department of General and Oncological Pulmonology, Medical University of Lodz, Lodz, Poland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Daria Domańska-Senderowska
            affiliation:
                  name:Medical University of Lodz
                  address:
                     name:Department of Molecular Bases of Medicine, Medical University of Lodz, Lodz, Poland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ewa Brzeziańska-Lasota
            affiliation:
                  name:Medical University of Lodz
                  address:
                     name:Department of Molecular Bases of Medicine, Medical University of Lodz, Lodz, Poland
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Molecular Biology Reports
      issn:
         1573-4978
         0301-4851
      volumeNumber:46
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Medical University of Lodz
      address:
         name:Department of General and Oncological Pulmonology, Medical University of Lodz, Lodz, Poland
         type:PostalAddress
      name:Medical University of Lodz
      address:
         name:Department of General and Oncological Pulmonology, Medical University of Lodz, Lodz, Poland
         type:PostalAddress
      name:Medical University of Lodz
      address:
         name:Department of Molecular Bases of Medicine, Medical University of Lodz, Lodz, Poland
         type:PostalAddress
      name:Medical University of Lodz
      address:
         name:Department of Molecular Bases of Medicine, Medical University of Lodz, Lodz, Poland
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Agata Dutkowska
      url:http://orcid.org/0000-0003-3882-979X
      affiliation:
            name:Medical University of Lodz
            address:
               name:Department of General and Oncological Pulmonology, Medical University of Lodz, Lodz, Poland
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Adam Antczak
      affiliation:
            name:Medical University of Lodz
            address:
               name:Department of General and Oncological Pulmonology, Medical University of Lodz, Lodz, Poland
               type:PostalAddress
            type:Organization
      name:Daria Domańska-Senderowska
      affiliation:
            name:Medical University of Lodz
            address:
               name:Department of Molecular Bases of Medicine, Medical University of Lodz, Lodz, Poland
               type:PostalAddress
            type:Organization
      name:Ewa Brzeziańska-Lasota
      affiliation:
            name:Medical University of Lodz
            address:
               name:Department of Molecular Bases of Medicine, Medical University of Lodz, Lodz, Poland
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of General and Oncological Pulmonology, Medical University of Lodz, Lodz, Poland
      name:Department of General and Oncological Pulmonology, Medical University of Lodz, Lodz, Poland
      name:Department of Molecular Bases of Medicine, Medical University of Lodz, Lodz, Poland
      name:Department of Molecular Bases of Medicine, Medical University of Lodz, Lodz, Poland

External Links {🔗}(74)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

3.93s.

LINK . SPRINGER . COM {}