We are analyzing https://link.springer.com/article/10.1007/s11010-007-9487-5.

Title:
Involvement of PPAR-γ and p53 in DHA-induced apoptosis in Reh cells | Molecular and Cellular Biochemistry
Description:
Docosahexaenoeic acid (DHA, 22:6 n-3) is an omega-3 polyunsaturated fatty acid that is found in fish oil and exerts cytotoxic effect on a variety of cell lines. The molecular target, responsible for mediating this effect of DHA, still remains unknown. In this report, we presented experimental evidences for the role of PPAR-γ in conveying the cytotoxic effect of DHA. We showed that DHA induces apoptosis in Reh and Ramos cells and apoptotic effect of DHA is inhibited by the PPAR-γ antagonist GW9662, indicating that PPAR-γ functions as the mediator of the apoptotic effect of DHA. Furthermore, our result showed that DHA induces the PPAR-γ protein levels in both Reh and Ramos cells. Interestingly, DHA was found to induce the expression of p53 protein in Reh cells in a PPAR-γ-dependent manner. The up-regulation of p53 protein by DHA kinetically correlated with the activation of caspase 9, caspase 3, and induction of apoptosis, suggesting a role for p53 in DHA-mediated apoptosis in Reh cells. Taken together, these findings suggest a new signaling pathway, DHA-PPAR-γ-p53, in mediating the apoptotic effect of DHA in Reh cells.
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Keywords {🔍}

article, google, scholar, pubmed, cas, cells, apoptosis, acid, cancer, cell, fatty, dha, human, docosahexaenoic, acids, pparγ, reh, effect, biochem, peroxisome, polyunsaturated, res, eicosapentaenoic, privacy, cookies, content, biochemistry, lines, protein, expression, access, lipid, receptors, breast, effects, int, ppargamma, publish, research, search, molecular, cellular, hamid, zand, role, induces, ramos, apoptotic, activation, oncol,

Topics {✒️}

peroxisome proliferator-activated receptor-gamma peroxisome proliferator-activated receptor-gamma peroxisome-proliferator activated receptors month download article/chapter t-cell lines compared lymphomas express ppar-gamma polyunsaturated fatty acids docosahexaenoic acid-induced benefit ppar-γ antagonist gw9662 upregulating bax/bcl-2 ratio docosahexaenoic acid-induced cytotoxicity protein kinase c-alpha ppar-γ-dependent manner malignant b-lineage cells omega-6 fatty acids ppar-γ protein levels pre-clinical models relevance nf-kappab signaling pathway dissecting p53-dependent apoptosis ppar-gamma agonists nuclear receptors dha-ppar-γ-p53 fatty acid modulation hematopoietic cell lines full article pdf ppargamma agonists ciglitazone ligand binding sites human ppargamma-lbd privacy choices/manage cookies ppar-γ functions ppar-γ antibody inducing adipocytes apoptosis narayanan nk basic medical sciences cell-cycle arrest rat granulosa cells eicosapentaenoic acid administered dha induces apoptosis dha-induced apoptosis ppargamma2 gene expression adiponectin gene expression cellular biochemistry aims related subjects narayanan ba article zand dietary menhaden oil cell lines dha-mediated apoptosis european economic area presented experimental evidences

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         description:Docosahexaenoeic acid (DHA, 22:6 n-3) is an omega-3 polyunsaturated fatty acid that is found in fish oil and exerts cytotoxic effect on a variety of cell lines. The molecular target, responsible for mediating this effect of DHA, still remains unknown. In this report, we presented experimental evidences for the role of PPAR-γ in conveying the cytotoxic effect of DHA. We showed that DHA induces apoptosis in Reh and Ramos cells and apoptotic effect of DHA is inhibited by the PPAR-γ antagonist GW9662, indicating that PPAR-γ functions as the mediator of the apoptotic effect of DHA. Furthermore, our result showed that DHA induces the PPAR-γ protein levels in both Reh and Ramos cells. Interestingly, DHA was found to induce the expression of p53 protein in Reh cells in a PPAR-γ-dependent manner. The up-regulation of p53 protein by DHA kinetically correlated with the activation of caspase 9, caspase 3, and induction of apoptosis, suggesting a role for p53 in DHA-mediated apoptosis in Reh cells. Taken together, these findings suggest a new signaling pathway, DHA-PPAR-γ-p53, in mediating the apoptotic effect of DHA in Reh cells.
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         Cancer Research
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