We are analyzing https://link.springer.com/article/10.1007/s10815-024-03301-8.

Title:
Role of epigenetic regulation in diminished ovarian reserve | Journal of Assisted Reproduction and Genetics
Description:
Diminished ovarian reserve (DOR) is characterized by a decrease in the number and quality of oocytes, with its incidence increasing annually. Its pathogenesis remains unclear, making it one of the most challenging problems in the field of assisted reproduction. Epigenetic modification, a molecular mechanism affecting genomic activity and expression without altering the DNA sequence, has been widely studied in reproductive medicine and has attracted considerable attention regarding DOR. This review comprehensively examines the various epigenetic regulatory changes in ovarian granulosa cells (OGCs) and oocytes during DOR. DNA methylation plays a crucial role in regulating granulosa cell function, hormone production, and oocyte development, maturation, and senescence. Histone modifications are involved in regulating follicular activation, while non-coding RNAs, such as long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), regulate granulosa cell function and oocyte development. N6-methyladenosine (m6A) modifications are associated with age-related oocyte senescence. Epigenetic clocks based on DNA methylation show potential in predicting ovarian reserve in DOR. Furthermore, it discusses the potential for utilizing epigenetic mechanisms to better diagnose and manage DOR.
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Keywords {🔍}

pubmed, google, scholar, ovarian, cas, dor, methylation, reserve, dna, epigenetic, oocyte, expression, central, article, cell, development, gcs, function, cells, gene, histone, modifications, levels, oocytes, granulosa, women, diminished, patients, reprod, regulation, studies, apoptosis, role, regulating, table, wang, zhang, chen, hormone, follicular, mechanisms, age, fto, activation, biol, liu, senescence, genes, factors, amh,

Topics {✒️}

tumor necrosis factor-alpha mir-642a-5p/foxo1 axis [44] mir-642a-5p/foxo1 axis pi3k-pten-akt-foxo3 pathway transcriptome-wide n6-methyladenine methylation suppressing pi3k/akt-mediated apoptosis natural science foundation tnf-α-induced inflammatory response stress-induced cognitive impairment article download pdf pten-akt-foxo3a pathway piwi-interacting rna profiles chemotherapy-induced ovarian toxicity age-related oocyte senescence mitochondria–paraspeckle axis regulates hdac small-molecule degraders regulate pi3k/akt signaling cyclophosphamide regulates n6-methyladenosine cyclophosphamide-induced damage meiosis-coupled mrna clearance turner syndrome results pi3k/akt signaling pathway engineered crispr-cas12a variants skewed x-chromosome inactivation promoting lc3a/3b9 expression full access age-related ovarian aging high-throughput sequencing regulating pi3k/akt signaling serum anti-müllerian hormone epigenetic gene-editing technologies transforming growth factor-β dna methylation-based biomarkers tet-mediated oxidative demethylation mir-221-3p regulates apoptosis follicle-stimulating hormone receptor histone methylation-targeted therapy anti-mullerian hormone regulation mir-6881-3p induces apoptosis key autophagy-related proteins nucleic acid-protein complex histone-modifying enzymes play moderate dna methylation de novo methylation arsenic-induced silencing histone modification patterns demethylase fto regulates ezh2 inhibitor enhances diminished ovarian reserve tumor cell line

Schema {🗺️}

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         headline:Role of epigenetic regulation in diminished ovarian reserve
         description:Diminished ovarian reserve (DOR) is characterized by a decrease in the number and quality of oocytes, with its incidence increasing annually. Its pathogenesis remains unclear, making it one of the most challenging problems in the field of assisted reproduction. Epigenetic modification, a molecular mechanism affecting genomic activity and expression without altering the DNA sequence, has been widely studied in reproductive medicine and has attracted considerable attention regarding DOR. This review comprehensively examines the various epigenetic regulatory changes in ovarian granulosa cells (OGCs) and oocytes during DOR. DNA methylation plays a crucial role in regulating granulosa cell function, hormone production, and oocyte development, maturation, and senescence. Histone modifications are involved in regulating follicular activation, while non-coding RNAs, such as long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), regulate granulosa cell function and oocyte development. N6-methyladenosine (m6A) modifications are associated with age-related oocyte senescence. Epigenetic clocks based on DNA methylation show potential in predicting ovarian reserve in DOR. Furthermore, it discusses the potential for utilizing epigenetic mechanisms to better diagnose and manage DOR.
         datePublished:2024-12-07T00:00:00Z
         dateModified:2024-12-07T00:00:00Z
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            Gene regulation
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            Reproductive Medicine
            Human Genetics
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      headline:Role of epigenetic regulation in diminished ovarian reserve
      description:Diminished ovarian reserve (DOR) is characterized by a decrease in the number and quality of oocytes, with its incidence increasing annually. Its pathogenesis remains unclear, making it one of the most challenging problems in the field of assisted reproduction. Epigenetic modification, a molecular mechanism affecting genomic activity and expression without altering the DNA sequence, has been widely studied in reproductive medicine and has attracted considerable attention regarding DOR. This review comprehensively examines the various epigenetic regulatory changes in ovarian granulosa cells (OGCs) and oocytes during DOR. DNA methylation plays a crucial role in regulating granulosa cell function, hormone production, and oocyte development, maturation, and senescence. Histone modifications are involved in regulating follicular activation, while non-coding RNAs, such as long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), regulate granulosa cell function and oocyte development. N6-methyladenosine (m6A) modifications are associated with age-related oocyte senescence. Epigenetic clocks based on DNA methylation show potential in predicting ovarian reserve in DOR. Furthermore, it discusses the potential for utilizing epigenetic mechanisms to better diagnose and manage DOR.
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         Diminished ovarian reserve
         Epigenetic modification
         Gene regulation
         Reproductive medicine
         Gynecology
         Reproductive Medicine
         Human Genetics
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