We are analyzing https://link.springer.com/article/10.1007/s10741-008-9129-3.

Title:
Relaxin, a pleiotropic vasodilator for the treatment of heart failure | Heart Failure Reviews
Description:
Relaxin is a naturally occurring peptide hormone that plays a central role in the hemodynamic and renovascular adaptive changes that occur during pregnancy. Triggering similar changes could potentially be beneficial in the treatment of patients with heart failure. The effects of relaxin include the production of nitric oxide, inhibition of endothelin, inhibition of angiotensin II, production of VEGF, and production of matrix metalloproteinases. These effects lead to systemic and renal vasodilation, increased arterial compliance, and other vascular changes. The recognition of this has led to the study of relaxin for the treatment of heart failure. An initial pilot study has shown favorable hemodynamic effects in patients with heart failure, including reduction in ventricular filling pressures and increased cardiac output. The ongoing RELAX-AHF clinical program is designed to evaluate the effects of relaxin on the symptoms and outcomes in a large group of patients admitted to hospital for acute heart failure. This review will summarize both the biology of relaxin and the data supporting its potential efficacy in human heart failure.
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Keywords {🔍}

relaxin, heart, failure, renal, google, scholar, article, pubmed, cas, patients, acute, vascular, vasodilation, human, effects, rats, systemic, function, pregnancy, hemodynamic, endothelin, arterial, subjects, study, cardiac, blood, pressure, receptor, increase, data, treatment, peptide, compliance, fig, increases, dose, clinical, receptors, gfr, doses, conrad, lgr, role, production, increased, cells, effect, infusion, full, hormone,

Topics {✒️}

l-arginine-nitric oxide pathway renin-angiotensin-aldosterone system article download pdf favorable benefit-risk profile g-protein coupled receptor mitogen-activated protein kinase 10–100 μg/kg/day appeared 240–960 μg/kg/day tended relaxin-stimulated tyrosine phosphorylation 1000 pg/ml levels attained counter-regulatory neurohormonal mechanisms open-label study pharmacodynamic dose-response parameters receptor closely related mediate maternal adjustments danielson la relaxin-induced renal vasodilation acute heart failure acute heart failure privacy choices/manage cookies diastolic blood pressure specific relaxin-binding cells human heart failure full access acute vascular failure relaxin-mediated renal vasodilation renal blood flow reduced myogenic reactivity human renal fibroblasts human dermal fibroblasts pre-relax-ahf ventricular filling pressures vasodilator peptide secreted sympathetic nervous system human endometrial cells worsening heart failure chronic heart failure recombinant human relaxin prior human testing hisaw fl jr systolic blood pressure elevated blood pressure heart failure studies guinea pigs injected 6–200 μg/kg/day 960 μg/kg/day μg/kg/day 6-kda peptide made relaxin stimulates expression type natriuretic peptide

Questions {❓}

Cotter G, Felker GM et al (2008) The pathophysiology of acute heart failure—Is it all about fluid accumulation?
Fisher C, MacLean M et al (2002) Is the pregnancy hormone relaxin also a vasodilator peptide secreted by the heart?
Milo-Cotter O, Adams KF et al (2007) Acute heart failure associated with high admission blood pressure—A distinct vascular disorder?
Schrier RW (2006) Role of diminished renal function in cardiovascular mortality: marker of pathogenetic factor?

Schema {🗺️}

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         description:Relaxin is a naturally occurring peptide hormone that plays a central role in the hemodynamic and renovascular adaptive changes that occur during pregnancy. Triggering similar changes could potentially be beneficial in the treatment of patients with heart failure. The effects of relaxin include the production of nitric oxide, inhibition of endothelin, inhibition of angiotensin II, production of VEGF, and production of matrix metalloproteinases. These effects lead to systemic and renal vasodilation, increased arterial compliance, and other vascular changes. The recognition of this has led to the study of relaxin for the treatment of heart failure. An initial pilot study has shown favorable hemodynamic effects in patients with heart failure, including reduction in ventricular filling pressures and increased cardiac output. The ongoing RELAX-AHF clinical program is designed to evaluate the effects of relaxin on the symptoms and outcomes in a large group of patients admitted to hospital for acute heart failure. This review will summarize both the biology of relaxin and the data supporting its potential efficacy in human heart failure.
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      headline:Relaxin, a pleiotropic vasodilator for the treatment of heart failure
      description:Relaxin is a naturally occurring peptide hormone that plays a central role in the hemodynamic and renovascular adaptive changes that occur during pregnancy. Triggering similar changes could potentially be beneficial in the treatment of patients with heart failure. The effects of relaxin include the production of nitric oxide, inhibition of endothelin, inhibition of angiotensin II, production of VEGF, and production of matrix metalloproteinases. These effects lead to systemic and renal vasodilation, increased arterial compliance, and other vascular changes. The recognition of this has led to the study of relaxin for the treatment of heart failure. An initial pilot study has shown favorable hemodynamic effects in patients with heart failure, including reduction in ventricular filling pressures and increased cardiac output. The ongoing RELAX-AHF clinical program is designed to evaluate the effects of relaxin on the symptoms and outcomes in a large group of patients admitted to hospital for acute heart failure. This review will summarize both the biology of relaxin and the data supporting its potential efficacy in human heart failure.
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         Renovascular
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      name:Corthera Inc., San Mateo, USA
      name:Department of Cardiology and Angiology, Charité Hospital – University Medicine, Berlin, Germany
      name:Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, USA
      name:Department of Cardiology, Thoraxcenter, University Medical Center Groningen, Groningen, The Netherlands
      name:Section of Cardiology, Veterans Affairs Medical Center, University of California, San Francisco, USA
      name:Department of Cardiology, Duke Clinical Research Institute, Durham, USA
      name:Section of Cardiovascular Diseases, Department of Experimental and Applied Medicine, University of Brescia, Brescia, Italy
      name:Momentum Research Inc., Durham, USA

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