We are analyzing https://link.springer.com/article/10.1007/s10620-021-07184-y.

Title:
NLRP3 Inflammasome Inhibitor OLT1177 Suppresses Onset of Inflammation in Mice with Dextran Sulfate Sodium-Induced Colitis | Digestive Diseases and Sciences
Description:
Background and Aims NLRP3 inflammasomes have been reported to have a key role in the initiation and perpetuation of inflammatory bowel diseases (IBD). Here we investigated the effects of OLT1177, a selective inhibitor of NLRP3 inflammasomes, in mice with dextran sulfate sodium (DSS)-induced colitis. Methods C57BL/6J mice were given drinking water containing 3% DSS for 5 days. OLT1177 was administered for 5 days during the induction phase (simultaneously with DSS treatment) or the recovery phase (after the DSS treatment ended). The body weight and disease activity index were monitored daily. The mice were sacrificed 10 days after the start of the experiment, and the severity of inflammation in the colon was determined based on histological and biochemical analyses. Results Administration of OLT1177 during the induction phase effectively suppressed DSS colitis in terms of weight loss, disease activity index, histological score, and expression of inflammatory cytokines compared to the DSS group. In contrast, OLT1177 administration during the recovery phase did not significantly affect the colitis disease course or the results of histological analyses. Conclusions OLT1177 was effective in preventing the onset of DSS colitis in mice. These results could guide the use of OLT1177 as a therapy for human IBD.
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Topics {✒️}

month download article/chapter dextran sulfate sodium β-sulfonyl nitrile compound oxazolone-induced colitis article digestive diseases induced ulcerative colitis inflammatory bowel diseases nlrp3 inflammasome activation full article pdf privacy choices/manage cookies intestinal mucosal cells inflammatory bowel disease acute colon inflammation targeting il-1β inflammasome signaling response inflammatory cytokines compared vivo inflammatory model inflammatory cell death induced colitis colitis induced ulcerative colitis nlrp3 inflammasomes european economic area related subjects nlr gene family nf-κb signaling overexpress growth hormone caspase-1 dynamics reveals dinitrobenzene sulfonic acid iwate medical university grant number jp21ek0410057 grant numbers 17k08702 disease activity index single-cell imaging conditions privacy policy arthritis res ther amplifying th17 responses ks critically reviewed cell death dis selective inhibitor dss treatment ended ks analyzed data induction phase electronic supplementary material accepting optional cookies kanneganti td ting jp ethics declarations conflict additional information publisher' article oizumi

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      description:NLRP3 inflammasomes have been reported to have a key role in the initiation and perpetuation of inflammatory bowel diseases (IBD). Here we investigated the effects of OLT1177, a selective inhibitor of NLRP3 inflammasomes, in mice with dextran sulfate sodium (DSS)-induced colitis. C57BL/6J mice were given drinking water containing 3% DSS for 5 days. OLT1177 was administered for 5 days during the induction phase (simultaneously with DSS treatment) or the recovery phase (after the DSS treatment ended). The body weight and disease activity index were monitored daily. The mice were sacrificed 10 days after the start of the experiment, and the severity of inflammation in the colon was determined based on histological and biochemical analyses. Administration of OLT1177 during the induction phase effectively suppressed DSS colitis in terms of weight loss, disease activity index, histological score, and expression of inflammatory cytokines compared to the DSS group. In contrast, OLT1177 administration during the recovery phase did not significantly affect the colitis disease course or the results of histological analyses. OLT1177 was effective in preventing the onset of DSS colitis in mice. These results could guide the use of OLT1177 as a therapy for human IBD.
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         Hepatology
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         Transplant Surgery
         Biochemistry
         general
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