We are analyzing https://link.springer.com/article/10.1007/s10620-009-0733-4.

Title:
Deficient Proliferation of Bone Marrow-Derived Mesenchymal Stem Cells in Patients with Chronic Hepatitis B Viral Infections and Cirrhosis of the Liver | Digestive Diseases and Sciences
Description:
In this study, we determined whether the proliferation of bone marrow-derived mesenchymal stem cells (MSCs) is impaired in patients with chronic hepatitis B viral infection and cirrhosis of the liver. MSCs from 15 patients with chronic hepatitis B and cirrhosis of the liver (CIR-MSCs) and 11 normal donors (ND-MSCs) were collected and characterized in vitro. CIR-MSCs displayed an intact immunophenotype. The percentage of S-phase nuclei in CIR-MSCs (4.34%), however, was significantly lower than that in ND-MSCs (P < 0.001), indicating impaired proliferation of CIR-MSCs. Growth factor receptor expression (e.g., IGF1, PDGFα, and PDGFβ) on the surface of CIR-MSCs decreased compared to that on ND-MSCs (P < 0.03). We found no evidence that CIR-MSCs were infected with the hepatitis B virus (HBV). Deficient proliferation of CIR-MSCs may result from the decreased expression of growth factor receptors and unbalanced production of cytokines in patients with HBV infection. Our results indicate that autologous MSCs of patients with chronic hepatitis B and cirrhosis of the liver may not be suitable for therapeutic purposes.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Education
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,625,932 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't see how the site brings in money.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

article, cells, bone, google, scholar, pubmed, hepatitis, liver, cas, mesenchymal, stem, chronic, marrowderived, patients, cirrhosis, infection, cirmscs, virus, marrow, proliferation, lin, privacy, cookies, content, access, human, information, publish, research, search, viral, zhong, deng, mscs, ndmscs, expression, hbv, fibrosis, stromal, hepatology, doihep, data, log, journal, diseases, deficient, infections, february, yuesi, nan,

Topics {✒️}

zhao-feng tang & rui-yun xu pre-s1 antigen-dependent infection month download article/chapter rui-yun xu serum bone gla-protein marrow stromal cells hedgehog-mediated paracrine interaction sun yat-sen university circulating pdc1/pdc2 ratio article digestive diseases cir-mscs decreased compared experimental liver fibrosis full article pdf bone marrow dynamic bone histomorphometry related subjects privacy choices/manage cookies hepatic stellate cells plasmacytoid dendritic cells s-phase nuclei chronic liver disease infectious diseases’ laboratory biliary tract cancer article zhong detecting hbv infections gene expression profile decompensated liver cirrhosis european economic area growth factor receptors vivo generated dc1 3rd affiliated hospital conditions privacy policy indicating impaired proliferation technology development fund professor lin yang 10 circulating cytokines/chemokines low turnover osteoporosis author information authors fu-cheng zhang arch iran med clin endocrinol metab cir-mscs displayed accepting optional cookies mei-hai deng albino rats—similarities tupaia hepatocyte cultures population-based study dendritic cells clin biochem med microbiol immunol

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Deficient Proliferation of Bone Marrow-Derived Mesenchymal Stem Cells in Patients with Chronic Hepatitis B Viral Infections and Cirrhosis of the Liver
         description:In this study, we determined whether the proliferation of bone marrow-derived mesenchymal stem cells (MSCs) is impaired in patients with chronic hepatitis B viral infection and cirrhosis of the liver. MSCs from 15 patients with chronic hepatitis B and cirrhosis of the liver (CIR-MSCs) and 11 normal donors (ND-MSCs) were collected and characterized in vitro. CIR-MSCs displayed an intact immunophenotype. The percentage of S-phase nuclei in CIR-MSCs (4.34%), however, was significantly lower than that in ND-MSCs (P < 0.001), indicating impaired proliferation of CIR-MSCs. Growth factor receptor expression (e.g., IGF1, PDGFα, and PDGFβ) on the surface of CIR-MSCs decreased compared to that on ND-MSCs (P < 0.03). We found no evidence that CIR-MSCs were infected with the hepatitis B virus (HBV). Deficient proliferation of CIR-MSCs may result from the decreased expression of growth factor receptors and unbalanced production of cytokines in patients with HBV infection. Our results indicate that autologous MSCs of patients with chronic hepatitis B and cirrhosis of the liver may not be suitable for therapeutic purposes.
         datePublished:2009-02-26T00:00:00Z
         dateModified:2009-02-26T00:00:00Z
         pageStart:438
         pageEnd:445
         sameAs:https://doi.org/10.1007/s10620-009-0733-4
         keywords:
            Bone marrow-derived mesenchymal stem cells
            Proliferation
            Hepatitis B virus
            Liver cirrhosis
            Gastroenterology
            Hepatology
            Oncology
            Transplant Surgery
            Biochemistry
            general
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-009-0733-4/MediaObjects/10620_2009_733_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-009-0733-4/MediaObjects/10620_2009_733_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-009-0733-4/MediaObjects/10620_2009_733_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-009-0733-4/MediaObjects/10620_2009_733_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-009-0733-4/MediaObjects/10620_2009_733_Fig5_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-009-0733-4/MediaObjects/10620_2009_733_Fig6_HTML.gif
         isPartOf:
            name:Digestive Diseases and Sciences
            issn:
               1573-2568
               0163-2116
            volumeNumber:55
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Yue-Si Zhong
               affiliation:
                     name:Sun Yat-Sen University
                     address:
                        name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Nan Lin
               affiliation:
                     name:Sun Yat-Sen University
                     address:
                        name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mei-Hai Deng
               affiliation:
                     name:Sun Yat-Sen University
                     address:
                        name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Fu-Cheng Zhang
               affiliation:
                     name:Sun Yat-Sen University
                     address:
                        name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zhao-Feng Tang
               affiliation:
                     name:Sun Yat-Sen University
                     address:
                        name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Rui-Yun Xu
               affiliation:
                     name:Sun Yat-Sen University
                     address:
                        name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Deficient Proliferation of Bone Marrow-Derived Mesenchymal Stem Cells in Patients with Chronic Hepatitis B Viral Infections and Cirrhosis of the Liver
      description:In this study, we determined whether the proliferation of bone marrow-derived mesenchymal stem cells (MSCs) is impaired in patients with chronic hepatitis B viral infection and cirrhosis of the liver. MSCs from 15 patients with chronic hepatitis B and cirrhosis of the liver (CIR-MSCs) and 11 normal donors (ND-MSCs) were collected and characterized in vitro. CIR-MSCs displayed an intact immunophenotype. The percentage of S-phase nuclei in CIR-MSCs (4.34%), however, was significantly lower than that in ND-MSCs (P < 0.001), indicating impaired proliferation of CIR-MSCs. Growth factor receptor expression (e.g., IGF1, PDGFα, and PDGFβ) on the surface of CIR-MSCs decreased compared to that on ND-MSCs (P < 0.03). We found no evidence that CIR-MSCs were infected with the hepatitis B virus (HBV). Deficient proliferation of CIR-MSCs may result from the decreased expression of growth factor receptors and unbalanced production of cytokines in patients with HBV infection. Our results indicate that autologous MSCs of patients with chronic hepatitis B and cirrhosis of the liver may not be suitable for therapeutic purposes.
      datePublished:2009-02-26T00:00:00Z
      dateModified:2009-02-26T00:00:00Z
      pageStart:438
      pageEnd:445
      sameAs:https://doi.org/10.1007/s10620-009-0733-4
      keywords:
         Bone marrow-derived mesenchymal stem cells
         Proliferation
         Hepatitis B virus
         Liver cirrhosis
         Gastroenterology
         Hepatology
         Oncology
         Transplant Surgery
         Biochemistry
         general
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-009-0733-4/MediaObjects/10620_2009_733_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-009-0733-4/MediaObjects/10620_2009_733_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-009-0733-4/MediaObjects/10620_2009_733_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-009-0733-4/MediaObjects/10620_2009_733_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-009-0733-4/MediaObjects/10620_2009_733_Fig5_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-009-0733-4/MediaObjects/10620_2009_733_Fig6_HTML.gif
      isPartOf:
         name:Digestive Diseases and Sciences
         issn:
            1573-2568
            0163-2116
         volumeNumber:55
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Yue-Si Zhong
            affiliation:
                  name:Sun Yat-Sen University
                  address:
                     name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Nan Lin
            affiliation:
                  name:Sun Yat-Sen University
                  address:
                     name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mei-Hai Deng
            affiliation:
                  name:Sun Yat-Sen University
                  address:
                     name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Fu-Cheng Zhang
            affiliation:
                  name:Sun Yat-Sen University
                  address:
                     name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zhao-Feng Tang
            affiliation:
                  name:Sun Yat-Sen University
                  address:
                     name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rui-Yun Xu
            affiliation:
                  name:Sun Yat-Sen University
                  address:
                     name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Digestive Diseases and Sciences
      issn:
         1573-2568
         0163-2116
      volumeNumber:55
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Sun Yat-Sen University
      address:
         name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
         type:PostalAddress
      name:Sun Yat-Sen University
      address:
         name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
         type:PostalAddress
      name:Sun Yat-Sen University
      address:
         name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
         type:PostalAddress
      name:Sun Yat-Sen University
      address:
         name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
         type:PostalAddress
      name:Sun Yat-Sen University
      address:
         name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
         type:PostalAddress
      name:Sun Yat-Sen University
      address:
         name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Yue-Si Zhong
      affiliation:
            name:Sun Yat-Sen University
            address:
               name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Nan Lin
      affiliation:
            name:Sun Yat-Sen University
            address:
               name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Mei-Hai Deng
      affiliation:
            name:Sun Yat-Sen University
            address:
               name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Fu-Cheng Zhang
      affiliation:
            name:Sun Yat-Sen University
            address:
               name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Zhao-Feng Tang
      affiliation:
            name:Sun Yat-Sen University
            address:
               name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Rui-Yun Xu
      affiliation:
            name:Sun Yat-Sen University
            address:
               name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
      name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
      name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
      name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
      name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
      name:Department of Hepatobiliary Surgery, 3rd Affiliated Hospital, Sun Yat-Sen University, GuangZhou, People’s Republic of China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(109)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.69s.

LINK . SPRINGER . COM {}