We are analyzing https://link.springer.com/article/10.1007/s10620-008-0223-0.

Title:
Risk Factors for Low Bone Mineral Density in Children and Adolescents with Inflammatory Bowel Disease | Digestive Diseases and Sciences
Description:
Objective To evaluate bone mineral density of the lumbar spine in children and adolescents with inflammatory bowel disease, and to identify the clinical risk factors associated with low bone mineral density. Methods Bone mineral density of the lumbar spine was evaluated using dual-energy X-ray absorptiometry (DXA) in 40 patients with inflammatory bowel disease. Patients were 11.8 (SD = 4.1) years old and most of them were male (52.5%). Multiple linear regression analysis was performed to identify potential associations between bone mineral density Z-score and age, height-for-age Z-score, BMI Z-score, cumulative corticosteroid dose in milligrams and in milligrams per kilogram, disease duration, number of relapses, and calcium intake according to the dietary reference intake. Results Low bone mineral density (Z-score bellow −2) was observed in 25% of patients. Patients with Crohn’s disease and ulcerative colitis had equivalent prevalence of low bone mineral density. Multiple linear regression models demonstrated that height-for-age Z-score, BMI Z-score, and cumulative corticosteroid dose in mg had independent effects on BMD, respectively, β = 0.492 (P = 0.000), β = 0.460 (P = 0.001), β = –0.014 (P = 0.000), and these effects remained significant after adjustments for disease duration, respectively, β = 0.489 (P = 0.013), β = 0.467 (P = 0.001), and β = −0.005 (P = 0.015). The model accounted for 54.6% of the variability of the BMD Z-score (adjusted R2 = 0.546). Conclusions The prevalence of low bone mineral density in children and adolescents with inflammatory bowel disease is considerably high and independent risk factors associated with bone mineral density are corticosteroid cumulative dose in milligrams, height-for-age Z-score, and BMI Z-score.
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bone, disease, google, scholar, article, pubmed, cas, mineral, density, inflammatory, bowel, patients, children, crohns, content, zscore, low, adolescents, pediatric, gut, factors, vera, osteoporosis, gastroenterol, gastroenterology, privacy, cookies, data, risk, sdepanian, study, dis, são, paulo, publish, search, lucia, szejnfeld, spine, corticosteroid, ulcerative, colitis, access, health, pediatr, mass, body, analysis, information, log,

Topics {✒️}

dual-energy x-ray absorptiometry month download article/chapter case-control cross-sectional study metabolic bone assessment article digestive diseases de priester ja inflammatory bowel disease full article pdf bone mineral density pediatric bone disease privacy choices/manage cookies clinical densitometry clinical risk factors decreased bone density bone mineral acquisition bone mineral content article lopes pediatric gastrointestinal disorders vera lucia sdepanian single photon absorptiometry pediatric reference data reduced bone density são paulo vera lúcia szejnfeld related subjects bmi z-score z-score bellow −2 trabecular bone loss corticosteroid-induced osteoporosis european economic area altered bone mass major predictive factors population based study female total body conditions privacy policy cumulative corticosteroid dose corticosteroid cumulative dose effects remained significant age z-score bmd z-score osteoporotic vertebral fractures vertebral compression fractures high-dose glucocorticoids bone health dietary reference intake pediatr clin north independent risk factors article log accepting optional cookies identify potential associations

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Jong DJ, Corstens FHM, Mannaerts L et al (2002) Corticosteroid-induced osteoporosis: does it occur in patients with Crohn’s disease?

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         description:Objective To evaluate bone mineral density of the lumbar spine in children and adolescents with inflammatory bowel disease, and to identify the clinical risk factors associated with low bone mineral density. Methods Bone mineral density of the lumbar spine was evaluated using dual-energy X-ray absorptiometry (DXA) in 40 patients with inflammatory bowel disease. Patients were 11.8 (SD = 4.1) years old and most of them were male (52.5%). Multiple linear regression analysis was performed to identify potential associations between bone mineral density Z-score and age, height-for-age Z-score, BMI Z-score, cumulative corticosteroid dose in milligrams and in milligrams per kilogram, disease duration, number of relapses, and calcium intake according to the dietary reference intake. Results Low bone mineral density (Z-score bellow −2) was observed in 25% of patients. Patients with Crohn’s disease and ulcerative colitis had equivalent prevalence of low bone mineral density. Multiple linear regression models demonstrated that height-for-age Z-score, BMI Z-score, and cumulative corticosteroid dose in mg had independent effects on BMD, respectively, β = 0.492 (P = 0.000), β = 0.460 (P = 0.001), β = –0.014 (P = 0.000), and these effects remained significant after adjustments for disease duration, respectively, β = 0.489 (P = 0.013), β = 0.467 (P = 0.001), and β = −0.005 (P = 0.015). The model accounted for 54.6% of the variability of the BMD Z-score (adjusted R2 = 0.546). Conclusions The prevalence of low bone mineral density in children and adolescents with inflammatory bowel disease is considerably high and independent risk factors associated with bone mineral density are corticosteroid cumulative dose in milligrams, height-for-age Z-score, and BMI Z-score.
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            Hepatology
            Oncology
            Transplant Surgery
            Biochemistry
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      description:Objective To evaluate bone mineral density of the lumbar spine in children and adolescents with inflammatory bowel disease, and to identify the clinical risk factors associated with low bone mineral density. Methods Bone mineral density of the lumbar spine was evaluated using dual-energy X-ray absorptiometry (DXA) in 40 patients with inflammatory bowel disease. Patients were 11.8 (SD = 4.1) years old and most of them were male (52.5%). Multiple linear regression analysis was performed to identify potential associations between bone mineral density Z-score and age, height-for-age Z-score, BMI Z-score, cumulative corticosteroid dose in milligrams and in milligrams per kilogram, disease duration, number of relapses, and calcium intake according to the dietary reference intake. Results Low bone mineral density (Z-score bellow −2) was observed in 25% of patients. Patients with Crohn’s disease and ulcerative colitis had equivalent prevalence of low bone mineral density. Multiple linear regression models demonstrated that height-for-age Z-score, BMI Z-score, and cumulative corticosteroid dose in mg had independent effects on BMD, respectively, β = 0.492 (P = 0.000), β = 0.460 (P = 0.001), β = –0.014 (P = 0.000), and these effects remained significant after adjustments for disease duration, respectively, β = 0.489 (P = 0.013), β = 0.467 (P = 0.001), and β = −0.005 (P = 0.015). The model accounted for 54.6% of the variability of the BMD Z-score (adjusted R2 = 0.546). Conclusions The prevalence of low bone mineral density in children and adolescents with inflammatory bowel disease is considerably high and independent risk factors associated with bone mineral density are corticosteroid cumulative dose in milligrams, height-for-age Z-score, and BMI Z-score.
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         Crohn’s disease
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         Adolescents
         Multivariate analysis
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         Hepatology
         Oncology
         Transplant Surgery
         Biochemistry
         general
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