We are analyzing https://link.springer.com/article/10.1007/s10555-008-9116-0.

Title:
SV40 small T antigen and PP2A phosphatase in cell transformation | Cancer and Metastasis Reviews
Description:
The SV40 early region protein, SV40 small t antigen, promotes cell transformation through negative regulation of the protein phosphatase 2A (PP2A) family of serine–threonine phosphatases. More recently, reduced levels of PP2A activity have been found in different types of human cancer. This occurs either through inactivating mutations of PP2A structural subunits, or by upregulation of the cellular PP2A inhibitors, CIP2A and SET. Several distinct PP2A complexes have been identified that contribute directly to tumor suppression by regulating specific phosphorylation events. These studies provide us with new insights into the role of protein phosphatases in cancer initiation and maintenance.
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Keywords {🔍}

google, scholar, cas, article, pubmed, protein, phosphatase, cell, journal, human, cancer, ppa, subunit, biology, antigen, cells, small, transformation, virus, molecular, simian, cellular, kinase, hahn, virology, tumor, regulatory, biological, chemistry, proceedings, research, regulation, set, chen, oncogene, gene, identification, growth, national, mumby, structure, nature, sontag, sablina, activity, role, regulates, sciences, signaling, william,

Topics {✒️}

induces anchorage-independent growth tumor suppressor nm23-h1 month download article/chapter v-src-induced phospholipase mtor-independent translational control cytokine-responsive ikappab kinase serine–threonine phosphatase 2a rac-bound beta1 integrin cell type-specific requirements pp2a-specific ppiase activity granzyme a-activated dnaase serine/threonine phosphatases implicated dana-farber cancer institute human tumor-cell proliferation transcription factor nf-kappab p21-activated kinase-pp2a tumor-suppressive functions telomerase-immortalized human fibroblasts leukemia-specific chromosome rearrangements cell cycle progression protein phosphatase inhibitors regulatory b-subunits full article pdf pp2a-dependent transactivation protein phosphatase 2a privacy choices/manage cookies induces cell proliferation map kinase pathway amino acid sequence ap-1-binding elements pleckstrin homology domain ras-induced tumorigenesis serine–threonine phosphatases zeta signaling targeted phospholipase d-dependent protein kinase cascades sv40 early genes stimulate ap-1 activity cip2a inhibits pp2a kidney epithelial cells metastasis reviews aims catalytic subunit isotypes cell growth promotion promote cell growth highly regulated family kinase suppressor c-myc 55-kda regulatory subunit 72-kda regulatory subunit isoform highly expressed

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         headline:SV40 small T antigen and PP2A phosphatase in cell transformation
         description:The SV40 early region protein, SV40 small t antigen, promotes cell transformation through negative regulation of the protein phosphatase 2A (PP2A) family of serine–threonine phosphatases. More recently, reduced levels of PP2A activity have been found in different types of human cancer. This occurs either through inactivating mutations of PP2A structural subunits, or by upregulation of the cellular PP2A inhibitors, CIP2A and SET. Several distinct PP2A complexes have been identified that contribute directly to tumor suppression by regulating specific phosphorylation events. These studies provide us with new insights into the role of protein phosphatases in cancer initiation and maintenance.
         datePublished:2008-01-23T00:00:00Z
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            Cancer
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      headline:SV40 small T antigen and PP2A phosphatase in cell transformation
      description:The SV40 early region protein, SV40 small t antigen, promotes cell transformation through negative regulation of the protein phosphatase 2A (PP2A) family of serine–threonine phosphatases. More recently, reduced levels of PP2A activity have been found in different types of human cancer. This occurs either through inactivating mutations of PP2A structural subunits, or by upregulation of the cellular PP2A inhibitors, CIP2A and SET. Several distinct PP2A complexes have been identified that contribute directly to tumor suppression by regulating specific phosphorylation events. These studies provide us with new insights into the role of protein phosphatases in cancer initiation and maintenance.
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         Transformation
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         general
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