We are analyzing https://link.springer.com/article/10.1007/s10067-015-2922-1.

Title:
Serum microRNAs as Potential Biomarkers of Juvenile Idiopathic Arthritis | Clinical Rheumatology
Description:
MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression of targeted mRNAs, which are important in the pathogenesis of autoimmune diseases. MiRNAs may have the potential to serve as biomarkers of disease. We evaluated serum levels of selected miRNAs and their associations with disease activity in juvenile idiopathic arthritis (JIA). Sera and peripheral blood leukocytes were collected from patients with JIA (8 systemic onset, 16 polyarthritis) and healthy controls. Levels of miR-16, miR-132, miR-146a, miR-155, and miR-223 were quantified. Levels of miR-223 in sera were significantly higher in patients in the active phase of systemic onset JIA than in controls. MiRNAs of peripheral blood leukocytes did not exhibit any difference between patients with JIA and controls. In both systemic onset JIA and polyarthritis patients, levels of miR-223 and miR-16 correlated with erythrocyte sedimentation rate and matrix metalloproteinase-3, respectively. MiR-146a and miR-223 in polyarthritis showed correlations with matrix metalloproteinase-3. Expressions of miRNAs were altered in patients with JIA. Serum levels of miR-223 may be a potential disease biomarker. Investigation of miRNAs could be helpful in understanding the pathogenesis of JIA and could aid in the identification of additional disease biomarkers.
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Keywords {🔍}

article, pubmed, arthritis, google, scholar, cas, juvenile, idiopathic, micrornas, rheumatoid, rheum, central, biomarkers, patients, serum, jia, systemic, microrna, potential, mirnas, disease, levels, access, wang, zhang, privacy, cookies, content, ito, expression, diseases, dis, gay, data, publish, search, rheumatology, kawada, kawano, iwata, martini, ann, author, rev, chen, res, chan, information, log, journal,

Topics {✒️}

month download article/chapter sensitive pcr-based quantitation nf-kappab-dependent induction stable blood-based markers juvenile idiopathic arthritis juvenile rheumatoid arthritis full article pdf o'briant kc early rheumatoid arthritis cell-free circulating micrornas upregulated mir-146a expression privacy choices/manage cookies post-transcriptional regulation related subjects tiny rna world coding rnas myeloid-related proteins 8 collagen-induced arthritis rheumatoid arthritis patients peripheral blood leukocytes article kamiya systemic onset jia s100a12 serum concentrations potential diagnostic biomarkers european economic area erythrocyte sedimentation rate cyclic citrullinated peptide monitoring neutrophil activation pogosova-agadjanyan el dominguez-gutierrez pr lentivirus-mediated silencing author information authors rheumatoid arthritis article log conditions privacy policy check access instant access innate immune responses additional disease biomarkers 1-2 osakada morioka-cho evaluated serum levels regulate gene expression yoshinori ito plasma microrna expressions microrna-mediated regulation accepting optional cookies chan ek systemic rheumatic diseases jun-ichi kawada polyarthritis showed correlations

Questions {❓}

Duroux-Richard I, Jorgensen C, Apparailly F (2012) What do microRNAs mean for rheumatoid arthritis?
Filipowicz W, Bhattacharyya SN, Sonenberg N (2008) Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

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