We are analyzing https://link.springer.com/article/10.1007/s00726-011-0981-4.

Title:
The non-proteinogenic amino acids l-methionine sulfoximine and dl-phosphinothricin activate mTOR | Amino Acids
Description:
l-Methionine sulfoximine (MSO) and dl-Phosphinothricin (PPT), two non-proteinogenic amino acids known as inhibitors of Glutamine Synthetase, cause a dose-dependent increase in the phosphorylation of the mTOR substrate S6 kinase 1. The effect is particularly evident in glutamine-depleted cells, where mTOR activity is very low, but is detectable for PPT also in the presence of glutamine. The stimulation of mTOR activity by either MSO or PPT is strongly synergized by essential amino acids. Thus, the non-proteinogenic amino acids MSO and PPT are mTOR activators.
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Keywords {🔍}

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Topics {✒️}

dl-phosphinothricin activate mtor month download article/chapter l-glutamic acid transport methionine sulfoximine author information authors ovidio bussolati valeria dall’asta article tardito neutral amino acids dl-phosphinothricin glutamine synthetase proteinogenic amino acids author correspondence mtor signaling pathway amino acid transporters glutamine-depleted cells 1007/s00726-010-0814 full article pdf privacy choices/manage cookies essential amino acids amino sugar mechanism check access slc38 gene family growth signal integration instant access european economic area dose-dependent increase rotoli bm cultured human fibroblasts vascular endothelial cells alpha-alkyl analogs asparaginase-resistant cells conditions privacy policy parma medical school gamma-glutamylcysteine synthetases chronic dietary leucine doctorate school dall’asta electronic supplementary material accepting optional cookies transport system asc structure-function relationships tissue-specific effects rina fallini fellowship glutamine synthetases amino acids amino acids 42 main content log renata franchi-gazzola glutamine deprivation

Questions {❓}

Fuchs BC, Bode BP (2005) Amino acid transporters asct2 and lat1 in cancer: partners in crime?

Schema {🗺️}

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         description: l-Methionine sulfoximine (MSO) and dl-Phosphinothricin (PPT), two non-proteinogenic amino acids known as inhibitors of Glutamine Synthetase, cause a dose-dependent increase in the phosphorylation of the mTOR substrate S6 kinase 1. The effect is particularly evident in glutamine-depleted cells, where mTOR activity is very low, but is detectable for PPT also in the presence of glutamine. The stimulation of mTOR activity by either MSO or PPT is strongly synergized by essential amino acids. Thus, the non-proteinogenic amino acids MSO and PPT are mTOR activators.
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