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  2. Matching Content Categories
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We are analyzing https://link.springer.com/article/10.1007/s00441-023-03786-2.

Title:
Erk5 functions in modulation of zebrafish intestinal permeability | Cell and Tissue Research
Description:
The intestine of zebrafish consists of mucosa, muscularis and serosa. Intestinal epithelial cells (IECs) act as a physical and biochemical barrier to protect against invasion by external commensal bacteria. Cell junction is one of the crucial basis of the barrier function. When cell junctions were disrupted, intestinal permeability would be naturally impeded. Extracellular signal-regulated kinase 5 (ERK5), belonging to the Mitogen-activated protein kinase (MAPK) family, is involved in the normal physiological development of the cardiovascular system and nervous system. But the role of erk5 in intestinal morphogenesis and intestinal function is yet to know. Here, we showed that knockout of the erk5 in zebrafish larvae resulted in intestinal wall hypoplasia, including the thinned intestinal wall, reduced intestinal folds, and disrupted cell junctions. In addition, the intestinal permeability assay demonstrated that knockout of erk5 resulted in increased intestinal permeability. All of these showed that erk5 plays an essential role in the maintenance of intestinal barrier function. Thus, our data indicate that erk5 is a critical effector in intestinal morphogenesis and intestinal function, and dysfunction of erk5 would lead to intestinal diseases.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {๐Ÿ“š}

  • Education
  • Science
  • Telecommunications

Content Management System {๐Ÿ“}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {๐Ÿ“ˆ}

What is the average monthly size of link.springer.com audience?

๐ŸŒ  Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 7,642,828 visitors per month in the current month.

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How Does Link.springer.com Make Money? {๐Ÿ’ธ}

We see no obvious way the site makes money.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Link.springer.com might have a hidden revenue stream, but it's not something we can detect.

Keywords {๐Ÿ”}

article, pubmed, intestinal, google, scholar, erk, cas, zebrafish, wang, cell, central, yang, function, permeability, barrier, sun, access, authors, data, research, jin, epithelial, junction, author, privacy, cookies, content, information, knockout, tight, yatsen, springer, publish, search, manuscript, ziwei, haihe, shulan, kinase, morphogenesis, open, expression, disease, biol, experiments, medicine, university, china, nature, supplementary,

Topics {โœ’๏ธ}

akt/mtor signaling pathway month download article/chapter intestinal epithelial cells mitogen-activated protein kinase de jong-curtain ta dongxia wangย contributed equally sun yat-sen university intestinal epithelium morphogenesis full article pdf zebrafish intestinal permeability haihe wang tissue research aims increased intestinal permeability intestinal barrier function related subjects privacy choices/manage cookies intestinal wall hypoplasia thinned intestinal wall reduced intestinal folds tight junction composition tight junction proteins nf-ฮบb activation laboratory animal center intestinal morphogenesis tumour cell proliferation green fluorescent protein mammalian map kinase check access instant access article cell article lv neurotrophin signaling mechanism intestinal permeability intestinal permeability temporally specific pattern holds exclusive rights induced disruption european economic area external commensal bacteria greenwood-van meerveld rare coding variants adolescent idiopathic scoliosis prl-3 initiates chordoma mediates neuron survival hypoxia-sensitive repressor transmission electronic microscope institutional animal care electronic supplementary material accepted manuscript version zebrafish larvae resulted

Schema {๐Ÿ—บ๏ธ}

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         description:The intestine of zebrafish consists of mucosa, muscularis and serosa. Intestinal epithelial cells (IECs) act as a physical and biochemical barrier to protect against invasion by external commensal bacteria. Cell junction is one of the crucial basis of the barrier function. When cell junctions were disrupted, intestinal permeability would be naturally impeded. Extracellular signal-regulated kinase 5 (ERK5), belonging to the Mitogen-activated protein kinase (MAPK) family, is involved in the normal physiological development of the cardiovascular system and nervous system. But the role of erk5 in intestinal morphogenesis and intestinal function is yet to know. Here, we showed that knockout of the erk5 in zebrafish larvae resulted in intestinal wall hypoplasia, including the thinned intestinal wall, reduced intestinal folds, and disrupted cell junctions. In addition, the intestinal permeability assay demonstrated that knockout of erk5 resulted in increased intestinal permeability. All of these showed that erk5 plays an essential role in the maintenance of intestinal barrier function. Thus, our data indicate that erk5 is a critical effector in intestinal morphogenesis and intestinal function, and dysfunction of erk5 would lead to intestinal diseases.
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             Erk5 knockout
            Intestinal morphogenesis
            Intestinal permeability
            Human Genetics
            Proteomics
            Molecular Medicine
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      headline:Erk5 functions in modulation of zebrafish intestinal permeability
      description:The intestine of zebrafish consists of mucosa, muscularis and serosa. Intestinal epithelial cells (IECs) act as a physical and biochemical barrier to protect against invasion by external commensal bacteria. Cell junction is one of the crucial basis of the barrier function. When cell junctions were disrupted, intestinal permeability would be naturally impeded. Extracellular signal-regulated kinase 5 (ERK5), belonging to the Mitogen-activated protein kinase (MAPK) family, is involved in the normal physiological development of the cardiovascular system and nervous system. But the role of erk5 in intestinal morphogenesis and intestinal function is yet to know. Here, we showed that knockout of the erk5 in zebrafish larvae resulted in intestinal wall hypoplasia, including the thinned intestinal wall, reduced intestinal folds, and disrupted cell junctions. In addition, the intestinal permeability assay demonstrated that knockout of erk5 resulted in increased intestinal permeability. All of these showed that erk5 plays an essential role in the maintenance of intestinal barrier function. Thus, our data indicate that erk5 is a critical effector in intestinal morphogenesis and intestinal function, and dysfunction of erk5 would lead to intestinal diseases.
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               type:PostalAddress
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      name:Haihe Wang
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      name:Center for Translational Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
      name:Guangdong Engineering & Technology Research Center for Disease-Model Animals, Laboratory Animal Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
      name:Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
      name:Center for Translational Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
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