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Title:
Wnt signaling and neural stem cells: caught in the Wnt web | Cell and Tissue Research
Description:
Wnt proteins have now been identified as major physiological regulators of multiple aspects of stem cell biology, from self-renewal and pluripotency to precursor cell competence and terminal differentiation. Neural stem cells are the cellular building blocks of the developing nervous system and provide the basis for continued neurogenesis in the adult mammalian central nervous system. Here, we outline the most recent advances in the field about the critical factors and regulatory networks involved in Wnt signaling and discuss recent findings on how this increasingly intricate pathway contributes to the shaping of the developing and adult nervous system on the level of the neural stem cell.
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Keywords {π}
google, scholar, pubmed, cas, wnt, cell, signaling, biol, development, cells, dev, neural, stem, mol, genes, nature, adult, pathway, neurosci, factor, protein, proteins, chem, transcription, activation, betacatenin, nat, regulates, sci, nuclear, signalling, differentiation, mouse, neurogenesis, tcf, van, neuronal, wntbetacatenin, canonical, regulation, usa, drosophila, science, research, article, dentate, transcriptional, wnta, proc, natl,
Topics {βοΈ}
n-methyl-d-aspartate receptor-mediated increase wnt/beta-catenin/t-cell factor signaling transgenic lef1/beta-catenin-dependent reporter notch/rbp-jkappa signalling pathway high-affinity ligand-receptor pair legless target armadillo/beta-catenin beta-catenin-dependent activation domain ldl-receptor-related protein essential mapping wnt/beta-catenin signaling regulate wnt/beta-catenin signalling beta-catenin-independent wnt signaling bcl9-2 binds arm/beta-catenin beta-catenin-tcf4 target tcf1 c-terminal binding protein beta-catenin-interacting protein beta-catenin-sensitive isoforms month download article/chapter transforming growth factor-beta wnt/beta-catenin activity nuclear arm/beta-catenin enhanced creb-dependent transcription beta-catenin-independent pathways wnt-mediated transcription activation divert nuclear beta-catenin stage-dependent fate determination tgf-beta signalling pathways epithelial stem-cell compartments ldl-receptor-related proteins beta-catenin/tcf transactivation lymphoid enhancer factor-1 roof plate-dependent patterning wnt/beta-catenin signaling wnt-beta-catenin signaling adult-generated granule cells neural stem cells membrane-bound o-acyltransferases adult hippocampus-derived progenitors t-cell factors cdx1-lef1 transcription complex enhances runx2-dependent activation wnt target axin2/conductin beta-catenin exerts effects stem cell biology neural stem cell pharmacological gsk-3-specific inhibitor epithelial stem cells i-mfa domain proteins sox2 enhancer n-1 jak-stat signaling controls regulates terminal arborization
Questions {β}
- Habas R, Dawid IB (2005) Dishevelled and Wnt signaling: is the nucleus the final frontier?
- Willert K, Jones KA (2006) Wnt signaling: is the party in the nucleus?
- Van Roy FM, McCrea PD (2005) A role for Kaiso-p120ctn complexes in cancer?
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headline:Wnt signaling and neural stem cells: caught in the Wnt web
description:Wnt proteins have now been identified as major physiological regulators of multiple aspects of stem cell biology, from self-renewal and pluripotency to precursor cell competence and terminal differentiation. Neural stem cells are the cellular building blocks of the developing nervous system and provide the basis for continued neurogenesis in the adult mammalian central nervous system. Here, we outline the most recent advances in the field about the critical factors and regulatory networks involved in Wnt signaling and discuss recent findings on how this increasingly intricate pathway contributes to the shaping of the developing and adult nervous system on the level of the neural stem cell.
datePublished:2007-09-09T00:00:00Z
dateModified:2007-09-09T00:00:00Z
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Signaling
Wnt
Stem cell
Neurogenesis
Development
Human Genetics
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headline:Wnt signaling and neural stem cells: caught in the Wnt web
description:Wnt proteins have now been identified as major physiological regulators of multiple aspects of stem cell biology, from self-renewal and pluripotency to precursor cell competence and terminal differentiation. Neural stem cells are the cellular building blocks of the developing nervous system and provide the basis for continued neurogenesis in the adult mammalian central nervous system. Here, we outline the most recent advances in the field about the critical factors and regulatory networks involved in Wnt signaling and discuss recent findings on how this increasingly intricate pathway contributes to the shaping of the developing and adult nervous system on the level of the neural stem cell.
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Neurogenesis
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