We are analyzing https://link.springer.com/article/10.1007/s00432-022-04549-2.

Title:
The basement membrane-related gene signature is associated with immunity and predicts survival accurately in hepatocellular carcinoma | Journal of Cancer Research and Clinical Oncology
Description:
Aims Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Expression defects and turnover of basement membrane (BM) proteins are key pathogenic factors in cancer. It is still uncertain how the expression of BM-related genes (BMGs) in HCC relates to prognosis. Methods All of the HCC cohort
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't see how the site brings in money.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

pubmed, article, google, scholar, cas, carcinoma, hepatocellular, central, cancer, immune, basement, signature, cell, analysis, research, gene, chen, genes, prognosis, hcc, membrane, patients, zhang, liver, risk, access, microenvironment, cells, authors, content, information, expression, bmgs, prognostic, tumor, matrix, laminin, oncol, fujian, privacy, cookies, data, journal, predicts, manuscript, zhao, hongbin, infiltration, mol, httpsdoiorgs,

Topics {✒️}

month download article/chapter suppressing tgf-beta signal immune-related genes predict basement membrane genes basement membrane component tumor immune microenvironment cellular tumor microenvironment ctsa gene mutations full article pdf subgroup analysis showed renal cell carcinoma hypoxia-related signature extracellular matrix signatures good prediction ability privacy choices/manage cookies precision oncology access immune-related pathways predicts survival accurately multivariate cox analyses bm-related genes hepatocellular carcinoma patients basement membrane exhaustion markers primary liver cancer standalone prognostic indicator immune cell infiltration immune checkpoint inhibitors low risk based immune feature analysis clinical oncology aims bm-related degs selected expression pattern holds exclusive rights risk score based research systematically built low-risk groups article journal european economic area key pathogenic factors protein–protein interaction force-dependent breaching extracellular matrix natural science foundation providing technical guidance high-risk group prognostic model ferroptosis-related seer-based study human disease associations liver cancer immunity

Questions {❓}

Lee CK, Chan SL, Chon HJ (2022) Could we predict the response of immune checkpoint inhibitor treatment in hepatocellular carcinoma?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The basement membrane-related gene signature is associated with immunity and predicts survival accurately in hepatocellular carcinoma
         description:Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Expression defects and turnover of basement membrane (BM) proteins are key pathogenic factors in cancer. It is still uncertain how the expression of BM-related genes (BMGs) in HCC relates to prognosis. All of the HCC cohort's RNA-seq and clinical information came from TCGA datasets. The least absolute shrinkage and selection operator (LASSO) regression algorithm was utilized to filter down the candidate genes and construct the prognostic model. Univariate and multivariate Cox analyses were run to examine if the risk score may serve as a standalone prognostic indicator. The single-sample gene set enrichment analysis (ssGSEA) was utilized to analyze examine immune cell infiltration and pathway activity. Five genes and their risk coefficients were eventually identified and patients with HCC were classified as either high or low risk based on the median of risk scores. Multivariate Cox regression analysis found a significant correlation between risk score and OS (p < 0.001). Subgroup analysis showed that BMGs signature had good prediction ability for HCC patients in age, gender, T stage, and AJCC stage (all p < 0.05). According to the ssGSEA, the high-risk subgroup showed higher levels of immune cell infiltration and immune-related pathways were more engaged in the high-risk group. Our research systematically built a prognostic model using risk score based on BMGs signature in HCC patients. The immune feature analysis of the BMGs signature indicated a potential regulation between tumor immunity and BM in HCC.
         datePublished:2022-12-27T00:00:00Z
         dateModified:2022-12-27T00:00:00Z
         pageStart:5751
         pageEnd:5760
         sameAs:https://doi.org/10.1007/s00432-022-04549-2
         keywords:
            Hepatocellular carcinoma
            Basement membrane
            Extracellular matrix
            Tumor microenvironment
            Prediction model
            Oncology
            Cancer Research
            Internal Medicine
            Hematology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00432-022-04549-2/MediaObjects/432_2022_4549_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00432-022-04549-2/MediaObjects/432_2022_4549_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00432-022-04549-2/MediaObjects/432_2022_4549_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00432-022-04549-2/MediaObjects/432_2022_4549_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00432-022-04549-2/MediaObjects/432_2022_4549_Fig5_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00432-022-04549-2/MediaObjects/432_2022_4549_Fig6_HTML.png
         isPartOf:
            name:Journal of Cancer Research and Clinical Oncology
            issn:
               1432-1335
               0171-5216
            volumeNumber:149
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Berlin Heidelberg
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Yu Zhao
               affiliation:
                     name:Affiliated Sanming First Hospital, Fujian Medical University
                     address:
                        name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zhenjie Yin
               affiliation:
                     name:Affiliated Sanming First Hospital, Fujian Medical University
                     address:
                        name:Department of Urology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kangming Huang
               affiliation:
                     name:Affiliated Sanming First Hospital, Fujian Medical University
                     address:
                        name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Fajing Zhang
               affiliation:
                     name:Affiliated Sanming First Hospital, Fujian Medical University
                     address:
                        name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yun Chen
               affiliation:
                     name:Affiliated Sanming First Hospital, Fujian Medical University
                     address:
                        name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yinghan Deng
               affiliation:
                     name:Affiliated Sanming First Hospital, Fujian Medical University
                     address:
                        name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hongbin Chen
               affiliation:
                     name:Affiliated Sanming First Hospital, Fujian Medical University
                     address:
                        name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The basement membrane-related gene signature is associated with immunity and predicts survival accurately in hepatocellular carcinoma
      description:Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Expression defects and turnover of basement membrane (BM) proteins are key pathogenic factors in cancer. It is still uncertain how the expression of BM-related genes (BMGs) in HCC relates to prognosis. All of the HCC cohort's RNA-seq and clinical information came from TCGA datasets. The least absolute shrinkage and selection operator (LASSO) regression algorithm was utilized to filter down the candidate genes and construct the prognostic model. Univariate and multivariate Cox analyses were run to examine if the risk score may serve as a standalone prognostic indicator. The single-sample gene set enrichment analysis (ssGSEA) was utilized to analyze examine immune cell infiltration and pathway activity. Five genes and their risk coefficients were eventually identified and patients with HCC were classified as either high or low risk based on the median of risk scores. Multivariate Cox regression analysis found a significant correlation between risk score and OS (p < 0.001). Subgroup analysis showed that BMGs signature had good prediction ability for HCC patients in age, gender, T stage, and AJCC stage (all p < 0.05). According to the ssGSEA, the high-risk subgroup showed higher levels of immune cell infiltration and immune-related pathways were more engaged in the high-risk group. Our research systematically built a prognostic model using risk score based on BMGs signature in HCC patients. The immune feature analysis of the BMGs signature indicated a potential regulation between tumor immunity and BM in HCC.
      datePublished:2022-12-27T00:00:00Z
      dateModified:2022-12-27T00:00:00Z
      pageStart:5751
      pageEnd:5760
      sameAs:https://doi.org/10.1007/s00432-022-04549-2
      keywords:
         Hepatocellular carcinoma
         Basement membrane
         Extracellular matrix
         Tumor microenvironment
         Prediction model
         Oncology
         Cancer Research
         Internal Medicine
         Hematology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00432-022-04549-2/MediaObjects/432_2022_4549_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00432-022-04549-2/MediaObjects/432_2022_4549_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00432-022-04549-2/MediaObjects/432_2022_4549_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00432-022-04549-2/MediaObjects/432_2022_4549_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00432-022-04549-2/MediaObjects/432_2022_4549_Fig5_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00432-022-04549-2/MediaObjects/432_2022_4549_Fig6_HTML.png
      isPartOf:
         name:Journal of Cancer Research and Clinical Oncology
         issn:
            1432-1335
            0171-5216
         volumeNumber:149
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Yu Zhao
            affiliation:
                  name:Affiliated Sanming First Hospital, Fujian Medical University
                  address:
                     name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zhenjie Yin
            affiliation:
                  name:Affiliated Sanming First Hospital, Fujian Medical University
                  address:
                     name:Department of Urology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kangming Huang
            affiliation:
                  name:Affiliated Sanming First Hospital, Fujian Medical University
                  address:
                     name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Fajing Zhang
            affiliation:
                  name:Affiliated Sanming First Hospital, Fujian Medical University
                  address:
                     name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yun Chen
            affiliation:
                  name:Affiliated Sanming First Hospital, Fujian Medical University
                  address:
                     name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yinghan Deng
            affiliation:
                  name:Affiliated Sanming First Hospital, Fujian Medical University
                  address:
                     name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hongbin Chen
            affiliation:
                  name:Affiliated Sanming First Hospital, Fujian Medical University
                  address:
                     name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Journal of Cancer Research and Clinical Oncology
      issn:
         1432-1335
         0171-5216
      volumeNumber:149
Organization:
      name:Springer Berlin Heidelberg
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Affiliated Sanming First Hospital, Fujian Medical University
      address:
         name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
         type:PostalAddress
      name:Affiliated Sanming First Hospital, Fujian Medical University
      address:
         name:Department of Urology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
         type:PostalAddress
      name:Affiliated Sanming First Hospital, Fujian Medical University
      address:
         name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
         type:PostalAddress
      name:Affiliated Sanming First Hospital, Fujian Medical University
      address:
         name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
         type:PostalAddress
      name:Affiliated Sanming First Hospital, Fujian Medical University
      address:
         name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
         type:PostalAddress
      name:Affiliated Sanming First Hospital, Fujian Medical University
      address:
         name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
         type:PostalAddress
      name:Affiliated Sanming First Hospital, Fujian Medical University
      address:
         name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Yu Zhao
      affiliation:
            name:Affiliated Sanming First Hospital, Fujian Medical University
            address:
               name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Zhenjie Yin
      affiliation:
            name:Affiliated Sanming First Hospital, Fujian Medical University
            address:
               name:Department of Urology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Kangming Huang
      affiliation:
            name:Affiliated Sanming First Hospital, Fujian Medical University
            address:
               name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Fajing Zhang
      affiliation:
            name:Affiliated Sanming First Hospital, Fujian Medical University
            address:
               name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Yun Chen
      affiliation:
            name:Affiliated Sanming First Hospital, Fujian Medical University
            address:
               name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Yinghan Deng
      affiliation:
            name:Affiliated Sanming First Hospital, Fujian Medical University
            address:
               name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Hongbin Chen
      affiliation:
            name:Affiliated Sanming First Hospital, Fujian Medical University
            address:
               name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
      name:Department of Urology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
      name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
      name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
      name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
      name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
      name:Department of Gastroenterology, Affiliated Sanming First Hospital, Fujian Medical University, Sanming, People’s Republic of China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(1)

https://link.springer.com/article/10.1007/s00432-022-04549-2/mailto:[email protected]

External Links {🔗}(205)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.29s.

LINK . SPRINGER . COM {}