We are analyzing https://link.springer.com/article/10.1007/s00430-010-0151-4.

Title:
Subsets, expansion and activation of myeloid-derived suppressor cells | Medical Microbiology and Immunology
Description:
Tumor cells and microorganisms manipulate the immune system to minimize any counter response in order to survive. Myeloid-derived suppressor cells (MDSC) in the mouse represent activated Gr-1+ CD11b+ myeloid precursor cells. Activation may occur through endogenous or exogenous factors leading to the suppression of immune responses. Under steady state conditions the same precursors differentiate into dendritic cells, macrophages and neutrophils. Their linkage to tumor progression and several suppression mechanisms employing the arginine metabolism are well documented, but knowledge of their role in chronic infections, autoimmune diseases and graft-versus-host reactions is just emerging. Several factors have been described to promote MDSC expansion and activation in bone marrow, spleen and tumor sites. New evidence suggests that the Gr-1 antibody itself may differentially trigger myelopoiesis under steady state conditions or induce apoptosis in inflammatory situations after binding to a common epitope expressed on Ly-6C and Ly-6G molecules, respectively. Moreover, two subsets of neutrophil- and monocyte-related MDSC have been described in tumor-bearing and healthy mice. In the present review, we summarize some early work leading to recent findings on these two MDSC subsets, the factors supporting MDSC expansion and activation, as well as novel insights on Gr-1 antibody functions.
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Topics {✒️}

granulocyte/macrophage colony-stimulating factor granulocyte-macrophage colony-stimulating factor granulocyte-macrophage colony-stimulating activity tumour-induced dendritic-cell defects immature gr-1 + cd11b + population induces innate immune cd11b + gr-1 + cells regulatory gr1 + cd11b + myeloid cells myeloid-derived suppressor cells gr-1 + cd11b + myeloid cells month download article/chapter peptide-based antitumor vaccines myeloid-derived suppressive cells lymphocyte-mediated tumor immunosurveillance granulocyte-depleting monoclonal antibody differentially trigger myelopoiesis colony stimulating factors stem-cell factor function cancer cell-derived pge2 c-erbb-2 transgenic balb/ membrane-bound tgf-beta 1 graft-versus-leukemia reactivity cd8 + t-lymphocyte subsets quantitative real-time pcr article medical microbiology virus-induced demyelinating disease graft-versus-host reactions myeloid suppressor cells early anti-listeria defense mouse bone marrow graft-versus-host reaction ehrlich tumor-bearing mice anti-ly-6 monoclonal antibody immature myeloid cells cells block cytotoxic bone marrow suppress squamous cell carcinoma macrophage suppressor activity tumor-induced immune suppression human dendritic cells myeloid lineage cells mouse ovarian carcinoma full article pdf donor lymphocyte infusions + early myeloid cells gr-1 antibody functions hematopoietic stem cells splenic natural suppressor t-cell anergy mac-1 +/gr-1 + cells murine dendritic cells

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         headline:Subsets, expansion and activation of myeloid-derived suppressor cells
         description:Tumor cells and microorganisms manipulate the immune system to minimize any counter response in order to survive. Myeloid-derived suppressor cells (MDSC) in the mouse represent activated Gr-1+ CD11b+ myeloid precursor cells. Activation may occur through endogenous or exogenous factors leading to the suppression of immune responses. Under steady state conditions the same precursors differentiate into dendritic cells, macrophages and neutrophils. Their linkage to tumor progression and several suppression mechanisms employing the arginine metabolism are well documented, but knowledge of their role in chronic infections, autoimmune diseases and graft-versus-host reactions is just emerging. Several factors have been described to promote MDSC expansion and activation in bone marrow, spleen and tumor sites. New evidence suggests that the Gr-1 antibody itself may differentially trigger myelopoiesis under steady state conditions or induce apoptosis in inflammatory situations after binding to a common epitope expressed on Ly-6C and Ly-6G molecules, respectively. Moreover, two subsets of neutrophil- and monocyte-related MDSC have been described in tumor-bearing and healthy mice. In the present review, we summarize some early work leading to recent findings on these two MDSC subsets, the factors supporting MDSC expansion and activation, as well as novel insights on Gr-1 antibody functions.
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      headline:Subsets, expansion and activation of myeloid-derived suppressor cells
      description:Tumor cells and microorganisms manipulate the immune system to minimize any counter response in order to survive. Myeloid-derived suppressor cells (MDSC) in the mouse represent activated Gr-1+ CD11b+ myeloid precursor cells. Activation may occur through endogenous or exogenous factors leading to the suppression of immune responses. Under steady state conditions the same precursors differentiate into dendritic cells, macrophages and neutrophils. Their linkage to tumor progression and several suppression mechanisms employing the arginine metabolism are well documented, but knowledge of their role in chronic infections, autoimmune diseases and graft-versus-host reactions is just emerging. Several factors have been described to promote MDSC expansion and activation in bone marrow, spleen and tumor sites. New evidence suggests that the Gr-1 antibody itself may differentially trigger myelopoiesis under steady state conditions or induce apoptosis in inflammatory situations after binding to a common epitope expressed on Ly-6C and Ly-6G molecules, respectively. Moreover, two subsets of neutrophil- and monocyte-related MDSC have been described in tumor-bearing and healthy mice. In the present review, we summarize some early work leading to recent findings on these two MDSC subsets, the factors supporting MDSC expansion and activation, as well as novel insights on Gr-1 antibody functions.
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