We are analyzing https://link.springer.com/article/10.1007/s00428-025-04029-1.

Title:
Pediatric cancer predisposition syndromes involving non-central nervous system solid pediatric tumors: a review on their manifestations with a focus on histopathology | Virchows Archiv
Description:
Germline genetic alterations and their associated cancer predisposition syndromes (CPS) are an important cause of pediatric cancer. Early recognition is of great importance for targeted surveillance, early detection, and prompt (personalized) therapeutic interventions. This review provides an overview of non-central nervous system solid pediatric tumor types, in relation to their associated CPS, with an emphasis on their histology. It serves as a guide for (pediatric) pathologists to increase their awareness of histological clues that suggest a CPS and warrant referral to the clinical geneticist.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Health & Fitness
Education

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

tumors, pubmed, pediatric, cps, article, tumor, syndrome, google, scholar, cancer, cell, patients, carcinoma, predisposition, thyroid, cells, germline, children, type, molecular, context, malignant, pathol, cas, syndromes, central, genetic, pathology, presence, variants, mutations, show, review, multiple, table, system, types, histological, familial, renal, solid, important, histology, clinical, tumours, rare, young, diagnosis, occur, fig,

Topics {✒️}

multiple café-au-lait spots wnt/β-catenin signaling pathway abundant eosinophilic cytoplasm central nervous system article download pdf pre-existent renal medulla pten-hamartoma tumor syndrome von hippel-lindau disease adenomas show fat-depleted simpson-golabi-behmel syndrome [52] simpson-golabi-behmel syndrome include carcinoid tumors hyperparathyroidism-jaw tumor syndrome pulmonary carcinoid tumors identify beckwith-wiedemann syndrome cancer predisposition syndromes apc/β-catenin pathway [55] dicer1-related thyroid tumors cancer predisposition evaluation spindle cell/sclerosing rhabdomyosarcoma include metabolic/genetic conditions apc/beta-catenin pathway dicer1-related sarcomas show north american society classic dnajb1-prkaca fusion germ cell tumors von hippel lindau bilateral/multifocal papillary tumors renal cell cancer renal cell carcinoma full access pediatric desmoid tumors desmoid-type fibromatosis pediatric adrenocortical carcinoma privacy choices/manage cookies cps-related thyroid pathology nervous system botryoid-type embryonal rhabdomyosarcoma beckwith-wiedemann syndrome beckwith-wiedemann syndrome [40 show solid parts pediatric thyroid cancer pediatric renal tumors small cell carcinoma multiple endocrine neoplasia hypercellular parathyroid tissue classify pediatric malignancies extra-adrenal paraganglia cancer-related genes pancreatic cancer syndrome

Questions {❓}

Papathomas TG, Suurd DPD, Pacak K et al (2021) What have we learned from molecular biology of paragangliomas and pheochromocytomas?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Pediatric cancer predisposition syndromes involving non-central nervous system solid pediatric tumors: a review on their manifestations with a focus on histopathology
         description:Germline genetic alterations and their associated cancer predisposition syndromes (CPS) are an important cause of pediatric cancer. Early recognition is of great importance for targeted surveillance, early detection, and prompt (personalized) therapeutic interventions. This review provides an overview of non-central nervous system solid pediatric tumor types, in relation to their associated CPS, with an emphasis on their histology. It serves as a guide for (pediatric) pathologists to increase their awareness of histological clues that suggest a CPS and warrant referral to the clinical geneticist.
         datePublished:2025-01-23T00:00:00Z
         dateModified:2025-01-23T00:00:00Z
         pageStart:3
         pageEnd:21
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1007/s00428-025-04029-1
         keywords:
            Pediatrics
            Cancer predisposition syndrome
            Histology
            Pathology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00428-025-04029-1/MediaObjects/428_2025_4029_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00428-025-04029-1/MediaObjects/428_2025_4029_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00428-025-04029-1/MediaObjects/428_2025_4029_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00428-025-04029-1/MediaObjects/428_2025_4029_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00428-025-04029-1/MediaObjects/428_2025_4029_Fig5_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00428-025-04029-1/MediaObjects/428_2025_4029_Fig6_HTML.jpg
         isPartOf:
            name:Virchows Archiv
            issn:
               1432-2307
               0945-6317
            volumeNumber:486
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Berlin Heidelberg
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:B. Schurink
               url:http://orcid.org/0000-0002-6523-2094
               affiliation:
                     name:Amsterdam University Medical Centers
                     address:
                        name:Department of Pathology, Amsterdam University Medical Centers, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
                     name:Princess Máxima Center for Pediatric Oncology
                     address:
                        name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:M. Reyes-Múgica
               affiliation:
                     name:University of Miami Miller School of Medicine
                     address:
                        name:Department of Pathology & Laboratory Medicine, University of Miami Miller School of Medicine, Miami, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:R. R. de Krijger
               affiliation:
                     name:Princess Máxima Center for Pediatric Oncology
                     address:
                        name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
                        type:PostalAddress
                     type:Organization
                     name:University Medical Center Utrecht
                     address:
                        name:Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Pediatric cancer predisposition syndromes involving non-central nervous system solid pediatric tumors: a review on their manifestations with a focus on histopathology
      description:Germline genetic alterations and their associated cancer predisposition syndromes (CPS) are an important cause of pediatric cancer. Early recognition is of great importance for targeted surveillance, early detection, and prompt (personalized) therapeutic interventions. This review provides an overview of non-central nervous system solid pediatric tumor types, in relation to their associated CPS, with an emphasis on their histology. It serves as a guide for (pediatric) pathologists to increase their awareness of histological clues that suggest a CPS and warrant referral to the clinical geneticist.
      datePublished:2025-01-23T00:00:00Z
      dateModified:2025-01-23T00:00:00Z
      pageStart:3
      pageEnd:21
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1007/s00428-025-04029-1
      keywords:
         Pediatrics
         Cancer predisposition syndrome
         Histology
         Pathology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00428-025-04029-1/MediaObjects/428_2025_4029_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00428-025-04029-1/MediaObjects/428_2025_4029_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00428-025-04029-1/MediaObjects/428_2025_4029_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00428-025-04029-1/MediaObjects/428_2025_4029_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00428-025-04029-1/MediaObjects/428_2025_4029_Fig5_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00428-025-04029-1/MediaObjects/428_2025_4029_Fig6_HTML.jpg
      isPartOf:
         name:Virchows Archiv
         issn:
            1432-2307
            0945-6317
         volumeNumber:486
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:B. Schurink
            url:http://orcid.org/0000-0002-6523-2094
            affiliation:
                  name:Amsterdam University Medical Centers
                  address:
                     name:Department of Pathology, Amsterdam University Medical Centers, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:Princess Máxima Center for Pediatric Oncology
                  address:
                     name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:M. Reyes-Múgica
            affiliation:
                  name:University of Miami Miller School of Medicine
                  address:
                     name:Department of Pathology & Laboratory Medicine, University of Miami Miller School of Medicine, Miami, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:R. R. de Krijger
            affiliation:
                  name:Princess Máxima Center for Pediatric Oncology
                  address:
                     name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:University Medical Center Utrecht
                  address:
                     name:Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Virchows Archiv
      issn:
         1432-2307
         0945-6317
      volumeNumber:486
Organization:
      name:Springer Berlin Heidelberg
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Amsterdam University Medical Centers
      address:
         name:Department of Pathology, Amsterdam University Medical Centers, Amsterdam, The Netherlands
         type:PostalAddress
      name:Princess Máxima Center for Pediatric Oncology
      address:
         name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
         type:PostalAddress
      name:University of Miami Miller School of Medicine
      address:
         name:Department of Pathology & Laboratory Medicine, University of Miami Miller School of Medicine, Miami, USA
         type:PostalAddress
      name:Princess Máxima Center for Pediatric Oncology
      address:
         name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
         type:PostalAddress
      name:University Medical Center Utrecht
      address:
         name:Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:B. Schurink
      url:http://orcid.org/0000-0002-6523-2094
      affiliation:
            name:Amsterdam University Medical Centers
            address:
               name:Department of Pathology, Amsterdam University Medical Centers, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
            name:Princess Máxima Center for Pediatric Oncology
            address:
               name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:M. Reyes-Múgica
      affiliation:
            name:University of Miami Miller School of Medicine
            address:
               name:Department of Pathology & Laboratory Medicine, University of Miami Miller School of Medicine, Miami, USA
               type:PostalAddress
            type:Organization
      name:R. R. de Krijger
      affiliation:
            name:Princess Máxima Center for Pediatric Oncology
            address:
               name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
               type:PostalAddress
            type:Organization
            name:University Medical Center Utrecht
            address:
               name:Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Pathology, Amsterdam University Medical Centers, Amsterdam, The Netherlands
      name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
      name:Department of Pathology & Laboratory Medicine, University of Miami Miller School of Medicine, Miami, USA
      name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
      name:Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands

External Links {🔗}(253)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

5.29s.

LINK . SPRINGER . COM {}