We are analyzing https://link.springer.com/article/10.1007/s00428-019-02568-y.

Title:
The composition of T cell infiltrates varies in primary invasive breast cancer of different molecular subtypes as well as according to tumor size and nodal status | Virchows Archiv
Description:
T lymphocytes are the most numerous immune cells in tumor-associated infiltrates and include several subpopulations of either anticancer or pro-tumorigenic functions. However, the associations between levels of different T cell subsets and breast cancer molecular subtypes as well as other prognostic factors have not been fully established yet. We performed immunohistochemistry for CD8 (cytotoxic T cells (CTL)), FOXP3 (regulatory T cells (Tregs)), and GATA3 (Th2 cells) in 106 formalin-fixed paraffin-embedded invasive breast cancer tissue samples and analyzed both the numbers and percentages of investigated cells in tumor-associated infiltrates. We observed that triple-negative breast cancer (TNBC) and HER2+ non-luminal breast tumors were associated with more numerous CTLs and Tregs and a higher Treg/Th2 cell ratio as compared with luminal A subtype. A higher Treg percentage was related to a decreased hormone receptor expression, an increase in the Ki67 level, a greater tumor size of luminal tumors, and the presence of lymph node metastases. Moreover, differences in the composition of T cell infiltrates were associated with HER2 status and histologic grade and type, and a distinct immune pattern was observed in tumors of different phenotypes regarding pT stage and nodal status. The results of our work show the diversity of T cell infiltrates in primary invasive breast cancers of different phenotypes and suggest that progression of luminal or non-luminal tumors is related to distinct tumor-associated T cell composition.
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Keywords {🔍}

breast, cancer, tumor, pubmed, article, cell, cells, google, scholar, invasive, luminal, higher, cas, infiltrates, cancers, lymphocytes, tumors, ctls, subtypes, tregs, percentage, molecular, immune, ratio, treg, prognostic, observed, nonluminal, edge, size, regulatory, foxp, central, tumorinfiltrating, tils, study, margin, ctl, numbers, primary, status, tissue, infiltrate, intratumoral, nodal, tumorassociated, tregth, microenvironment, composition, expression,

Topics {✒️}

formalin-fixed paraffin-embedded tissues archival hematoxylin-eosin–stained slides article download pdf cytokine-induced il-10–secreting cd8 cd8+ t-cell infiltration ctl/treg number ratio tumour-infiltrating lymphocytes triple-negative breast cancer node-positive invasive tumors higher cd8+/foxp3+ ratio stage iii/iv cancers article glajcar full size image her2-overexpressing breast cancers lymph node metastases higher percentage ratio er-positive breast cancers tumor-infiltrating lymphocytes rich th2 cell percentage decreased pulmonary metastasis privacy choices/manage cookies full access breast cancer-related ctls higher treg percentage human breast cancer early breast cancer diana hodorowicz-zaniewska jagiellonian university committee intrinsic molecular subtypes human breast tumours good clinical outcome breast cancer tissue reveal differential vascular intensive treg infiltration lower treg percentage differential tumor infiltration th2 cell impact potent cell killing invasive breast cancer primary breast cancers th2 cells showed regulatory foxp3 + cells tumor th2 cell infiltrates breast cancer subtypes positively stained cells central point breast cancer treated breast cancer prognosis stage iii/iv cancer molecular features

Schema {🗺️}

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         headline:The composition of T cell infiltrates varies in primary invasive breast cancer of different molecular subtypes as well as according to tumor size and nodal status
         description:T lymphocytes are the most numerous immune cells in tumor-associated infiltrates and include several subpopulations of either anticancer or pro-tumorigenic functions. However, the associations between levels of different T cell subsets and breast cancer molecular subtypes as well as other prognostic factors have not been fully established yet. We performed immunohistochemistry for CD8 (cytotoxic T cells (CTL)), FOXP3 (regulatory T cells (Tregs)), and GATA3 (Th2 cells) in 106 formalin-fixed paraffin-embedded invasive breast cancer tissue samples and analyzed both the numbers and percentages of investigated cells in tumor-associated infiltrates. We observed that triple-negative breast cancer (TNBC) and HER2+ non-luminal breast tumors were associated with more numerous CTLs and Tregs and a higher Treg/Th2 cell ratio as compared with luminal A subtype. A higher Treg percentage was related to a decreased hormone receptor expression, an increase in the Ki67 level, a greater tumor size of luminal tumors, and the presence of lymph node metastases. Moreover, differences in the composition of T cell infiltrates were associated with HER2 status and histologic grade and type, and a distinct immune pattern was observed in tumors of different phenotypes regarding pT stage and nodal status. The results of our work show the diversity of T cell infiltrates in primary invasive breast cancers of different phenotypes and suggest that progression of luminal or non-luminal tumors is related to distinct tumor-associated T cell composition.
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         dateModified:2019-04-17T00:00:00Z
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      headline:The composition of T cell infiltrates varies in primary invasive breast cancer of different molecular subtypes as well as according to tumor size and nodal status
      description:T lymphocytes are the most numerous immune cells in tumor-associated infiltrates and include several subpopulations of either anticancer or pro-tumorigenic functions. However, the associations between levels of different T cell subsets and breast cancer molecular subtypes as well as other prognostic factors have not been fully established yet. We performed immunohistochemistry for CD8 (cytotoxic T cells (CTL)), FOXP3 (regulatory T cells (Tregs)), and GATA3 (Th2 cells) in 106 formalin-fixed paraffin-embedded invasive breast cancer tissue samples and analyzed both the numbers and percentages of investigated cells in tumor-associated infiltrates. We observed that triple-negative breast cancer (TNBC) and HER2+ non-luminal breast tumors were associated with more numerous CTLs and Tregs and a higher Treg/Th2 cell ratio as compared with luminal A subtype. A higher Treg percentage was related to a decreased hormone receptor expression, an increase in the Ki67 level, a greater tumor size of luminal tumors, and the presence of lymph node metastases. Moreover, differences in the composition of T cell infiltrates were associated with HER2 status and histologic grade and type, and a distinct immune pattern was observed in tumors of different phenotypes regarding pT stage and nodal status. The results of our work show the diversity of T cell infiltrates in primary invasive breast cancers of different phenotypes and suggest that progression of luminal or non-luminal tumors is related to distinct tumor-associated T cell composition.
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         Microenvironment
         Cytotoxic T cells
         Regulatory T cells
         Th2 cells
         Tumor-infiltrating lymphocytes
         Pathology
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            address:
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               type:PostalAddress
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      name:Department of Pathomorphology, Jagiellonian University Medical College, Kraków, Poland

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