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Title:
Stem cells and solid cancers | Virchows Archiv
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Recently, there have been significant advances in our knowledge of stem cells found in tissues that can develop solid tumours. In particular, novel stem cell markers have been identified for the first time identifying multipotential cells: a required characteristic of a stem cell. The scarcity of cancer stem cells has been questioned. Current dogma states that they are rare, but novel research has suggested that this may not be the case. Here, we review the latest literature on stem cells, particularly cancer stem cells within solid tumours. We discuss current thinking on how stem cells develop into cancer stem cells and how they protect themselves from doing so and do they express unique markers that can be used to detect stem cells. We attempt to put into perspective these latest advances in stem cell biology and their potential for cancer therapy.
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Questions {❓}
- Alison MR, Poulsom R, Otto WR et al (2003) Plastic adult stem cells: will they graduate from the school of hard knocks?
- Borovski T, Vermeulen L, Sprick MR et al (2009) One renegade cancer stem cell?
- Lansdorp PM (2007) Immortal strands?
- Yoo MH, Hatfield DL (2008) The cancer stem cell theory: is it correct?
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headline:Stem cells and solid cancers
description:Recently, there have been significant advances in our knowledge of stem cells found in tissues that can develop solid tumours. In particular, novel stem cell markers have been identified for the first time identifying multipotential cells: a required characteristic of a stem cell. The scarcity of cancer stem cells has been questioned. Current dogma states that they are rare, but novel research has suggested that this may not be the case. Here, we review the latest literature on stem cells, particularly cancer stem cells within solid tumours. We discuss current thinking on how stem cells develop into cancer stem cells and how they protect themselves from doing so and do they express unique markers that can be used to detect stem cells. We attempt to put into perspective these latest advances in stem cell biology and their potential for cancer therapy.
datePublished:2009-06-05T00:00:00Z
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Stem cell
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Intestine
Liver
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