We are analyzing https://link.springer.com/article/10.1007/s00428-006-0176-7.

Title:
Atherosclerosis research from past to present—on the track of two pathologists with opposing views, Carl von Rokitansky and Rudolf Virchow | Virchows Archiv
Description:
It is now clear that inflammation plays a key role in atherogenesis. As a matter of fact, signs of inflammation of atherosclerotic plaques have been observed for centuries and also constituted the basis for a fierce controversy in the 19th century between the prominent Austrian pathologist Carl von Rokitansky and his German counterpart, Rudolf Virchow. While the former attributed a secondary role to these inflammatory arterial changes, Virchow considered them to be of primary importance. We had the unique opportunity to address this controversy by investigating atherosclerotic specimens from autopsies performed by Carl von Rokitansky up to 178 years ago. Twelve atherosclerotic arteries originally collected between the years 1827 to 1885 were selected from the Collectio Rokitansky of the Federal Museum of Pathological Anatomy, Vienna Medical University. Using modern sophisticated immunohistochemical and immunofluorescence techniques, it was shown that various cellular intralesional components, as well as extracellular matrix proteins, were preserved in the historic atherosclerotic specimens. Most importantly, CD3 positive cells were abundant in early lesions, thus, rather supporting Virchows’s view, that inflammation is an initiating factor in atherogenesis. Furthermore, we hope to have opened a new and intriguing possibility to study various pathological conditions using valuable historical specimens.
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Topics {✒️}

cross-reactive b-cell epitopes t-lymphocytes bearing alpha/beta month download article/chapter apolipoprotein e-deficient mice ldl-receptor deficient mice promoting fatty-streak formation van der zee carl von rokitansky full article pdf privacy choices/manage cookies austrian science fund pre-historic material human atherosclerotic plaque valuable historical specimens gamma/delta receptor humoral immune responses extracellular matrix proteins van lenten bj aged human specimens texas heart inst coronary artery disease acute coronary syndromes ruth pfeilschifter-resch preparing paraffin sections county hospital feldkirch fritz-pregl str human atherosclerotic lesions investigating atherosclerotic specimens atherosclerosis research related subjects european economic area modern sophisticated immunohistochemical cd3 positive cells cd1d-dependent activation degenerative vascular disease vascular events leading arterial lesions found university hospital innsbruck conditions privacy policy georg wick historic atherosclerotic specimens accepting optional cookies cellular intralesional components previously unrecognized site high density lipoproteins innsbruck medical university university hospital vienna article log pancreatic diseaes past article mayerl

Questions {❓}

Nieto FJ (1998) Infections and atherosclerosis: new clues from an old hypothesis?

Schema {🗺️}

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