We are analyzing https://link.springer.com/article/10.1007/s00424-006-0069-2.

Title:
P2 receptors: intracellular signaling | Pflügers Archiv - European Journal of Physiology
Description:
P2 receptors for extracellular nucleotides are divided into two categories: the ion channel receptors (P2X) and the G-protein-coupled receptors (P2Y). For the P2X receptors, signal transduction appears to be relatively simple. Upon activation by extracellular ATP, a channel comprised of P2X receptor subunits opens and allows cations to move across the plasma membrane, resulting in changes in the electrical potential of the cell that, in turn, propagates a signal. This regulated flux of ions across the plasma membrane has important signaling functions, especially in impulse propagation in the nervous system and in muscle contractility. In addition, P2X receptor activation causes the accumulation of calcium ions in the cytoplasm, which is responsible for activating numerous signaling molecules. For the P2Y receptors, signal transduction is more complex. Intracellular signaling cascades are the main routes of communication between G-protein-coupled receptors and regulatory targets within the cell. These signaling cascades operate mainly by the sequential activation or deactivation of heterotrimeric and monomeric G proteins, phospholipases, protein kinases, adenylyl and guanylyl cyclases, and phosphodiesterases that regulate many cellular processes, including proliferation, differentiation, apoptosis, metabolism, secretion, and cell migration. In addition, there are numerous ion channels, cell adhesion molecules and receptor tyrosine kinases that are modulated by P2Y receptors and operate to transmit an extracellular signal to an intracellular response. These intracellular signaling pathways and their regulation by P2 receptors are discussed in this review.
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Keywords {🔍}

google, scholar, pubmed, cas, article, receptor, receptors, human, biol, nucleotide, physiol, chem, cell, cells, pharmacol, atp, activation, expression, signaling, erb, weisman, extracellular, protein, mol, biochem, ion, functional, res, gonzalez, seye, kinase, rat, muscle, kinases, cloning, sci, desensitization, garrad, north, intracellular, channels, regulation, murine, camden, nature, purinergic, release, smooth, signal, signalling,

Topics {✒️}

month download article/chapter nitric oxide synthase ras/raf/mek/mapk pathway g-protein-coupled receptor regulation n-type calcium currents y1 gi/o-coupled receptors g-protein-coupled receptors atp-activated ion channels mitogen-activated protein kinase ligand-gated ion channels p2x7 receptor-dependent blebbing mitogen-activated protein kinases p2y2 receptor-stimulated release protein-coupled receptor sp1999 cell cycle progression reduced pain-related behaviour beta-arrestin-2-dependent internalization distinct kinase-dependent mechanisms atp receptor-mediated enhancement p2x4 receptors induced protein-coupled p2y receptors distal c-terminal region galphai-coupled adp receptor cloned human p2u-purinoceptor ion channel receptors capsaicin receptor activity cell adhesion molecules lipid-interaction motifs including c-terminal motif found differential agonist-induced desensitization numerous ion channels p2y2 nucleotide receptors neuronal ion channels p2y2 nucleotide receptor nucleotide receptor expression protein-coupled receptors p2x7 nucleotide receptor nucleotide receptor p2x7 protein-coupled receptor full article pdf receptor-mediated proliferation agonist-induced phosphorylation purinergic receptor expression mediated signal transduction arachidonic acid mobilization atp-gated channels vascular endothelial cells receptor gene expression p2-purinergic receptors nucleotide receptor signaling

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         Cell Biology
         Receptors
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