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article, pubmed, google, scholar, cas, gliomas, cancer, heidelberg, university, grading, central, germany, idhmutant, idh, neuropathol, department, acta, grade, center, classification, astrocytic, german, research, david, tumors, diffuse, louis, hospital, supplementary, analysis, deimling, clinical, set, medical, health, status, prognostic, deletion, berlin, data, world, organization, nervous, system, astrocytoma, glioblastoma, tumor, discovery, cdknab, homozygous,

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month download article/chapter melanie bewerunge-hudler andreas von deimling kaplan–meier plots stratifying idh-mutant astrocytic gliomas neuropathology-haarlem consensus guidelines real-time molecular profiling humboldt-universität zu berlin idh-mutant astrocytoma based diffuse lower-grade gliomas central nervous system idh gene status full article pdf dna methylation-based classification idh mutation status brain tumor center neuroscience research center p16 gene deletions parsons dw german cancer consortium intermediate-grade infiltrating astrocytomas diffuse astrocytic gliomas idh-mutant astrocytoma privacy choices/manage cookies adult infiltrating gliomas lurie cancer center idh mutant diffuse brain tumor biology clinical data acquisition idh1 r132h mutation german cancer aid hiroaki shimizu related subjects idh-mutant gliomas harvard medical school grade iii gliomas copy number variation diffuse astrocytic tumors lower grade gliomas differentiating grade ii von deimling monoclonal antibody specific medical faculty mannheim box-plots correspond louis dn article shirahata versus quantitative pcr massachusetts general hospital eortc validation set electronic supplementary material

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      mainEntity:
         headline:Novel, improved grading system(s) for IDH-mutant astrocytic gliomas
         description:According to the 2016 World Health Organization Classification of Tumors of the Central Nervous System (2016 CNS WHO), IDH-mutant astrocytic gliomas comprised WHO grade II diffuse astrocytoma, IDH-mutant (AIIIDHmut), WHO grade III anaplastic astrocytoma, IDH-mutant (AAIIIIDHmut), and WHO grade IV glioblastoma, IDH-mutant (GBMIDHmut). Notably, IDH gene status has been made the major criterion for classification while the manner of grading has remained unchanged: it is based on histological criteria that arose from studies which antedated knowledge of the importance of IDH status in diffuse astrocytic tumor prognostic assessment. Several studies have now demonstrated that the anticipated differences in survival between the newly defined AIIIDHmut and AAIIIIDHmut have lost their significance. In contrast, GBMIDHmut still exhibits a significantly worse outcome than its lower grade IDH-mutant counterparts. To address the problem of establishing prognostically significant grading for IDH-mutant astrocytic gliomas in the IDH era, we undertook a comprehensive study that included assessment of histological and genetic approaches to prognosis in these tumors. A discovery cohort of 211 IDH-mutant astrocytic gliomas with an extended observation was subjected to histological review, image analysis, and DNA methylation studies. Tumor group-specific methylation profiles and copy number variation (CNV) profiles were established for all gliomas. Algorithms for automated CNV analysis were developed. All tumors exhibiting 1p/19q codeletion were excluded from the series. We developed algorithms for grading, based on molecular, morphological and clinical data. Performance of these algorithms was compared with that of WHO grading. Three independent cohorts of 108, 154 and 224 IDH-mutant astrocytic gliomas were used to validate this approach. In the discovery cohort several molecular and clinical parameters were of prognostic relevance. Most relevant for overall survival (OS) was CDKN2A/B homozygous deletion. Other parameters with major influence were necrosis and the total number of CNV. Proliferation as assessed by mitotic count, which is a key parameter in 2016 CNS WHO grading, was of only minor influence. Employing the parameters most relevant for OS in our discovery set, we developed two models for grading these tumors. These models performed significantly better than WHO grading in both the discovery and the validation sets. Our novel algorithms for grading IDH-mutant astrocytic gliomas overcome the challenges caused by introduction of IDH status into the WHO classification of diffuse astrocytic tumors. We propose that these revised approaches be used for grading of these tumors and incorporated into future WHO criteria.
         datePublished:2018-04-23T00:00:00Z
         dateModified:2018-04-23T00:00:00Z
         pageStart:153
         pageEnd:166
         sameAs:https://doi.org/10.1007/s00401-018-1849-4
         keywords:
            Astrocytoma
            Glioblastoma
            IDH
            Grading
            CDKN2A/B
            Pathology
            Neurosciences
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         isPartOf:
            name:Acta Neuropathologica
            issn:
               1432-0533
               0001-6322
            volumeNumber:136
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               name:Mitsuaki Shirahata
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                     name:Saitama Medical University International Medical Center
                     address:
                        name:Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Japan
                        type:PostalAddress
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               name:Takahiro Ono
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                     name:Heidelberg University Hospital
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                        name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
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                     name:Akita University Graduate School of Medicine
                     address:
                        name:Department of Neurosurgery, Akita University Graduate School of Medicine, Akita, Japan
                        type:PostalAddress
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               name:Damian Stichel
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                     address:
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               name:Andreas von Deimling
               affiliation:
                     name:Heidelberg University Hospital
                     address:
                        name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
                     address:
                        name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:University of Heidelberg and DKFZ
                     address:
                        name:Department for Neuropathology and CCU Neuropathology, University of Heidelberg and DKFZ, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               email:[email protected]
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ScholarlyArticle:
      headline:Novel, improved grading system(s) for IDH-mutant astrocytic gliomas
      description:According to the 2016 World Health Organization Classification of Tumors of the Central Nervous System (2016 CNS WHO), IDH-mutant astrocytic gliomas comprised WHO grade II diffuse astrocytoma, IDH-mutant (AIIIDHmut), WHO grade III anaplastic astrocytoma, IDH-mutant (AAIIIIDHmut), and WHO grade IV glioblastoma, IDH-mutant (GBMIDHmut). Notably, IDH gene status has been made the major criterion for classification while the manner of grading has remained unchanged: it is based on histological criteria that arose from studies which antedated knowledge of the importance of IDH status in diffuse astrocytic tumor prognostic assessment. Several studies have now demonstrated that the anticipated differences in survival between the newly defined AIIIDHmut and AAIIIIDHmut have lost their significance. In contrast, GBMIDHmut still exhibits a significantly worse outcome than its lower grade IDH-mutant counterparts. To address the problem of establishing prognostically significant grading for IDH-mutant astrocytic gliomas in the IDH era, we undertook a comprehensive study that included assessment of histological and genetic approaches to prognosis in these tumors. A discovery cohort of 211 IDH-mutant astrocytic gliomas with an extended observation was subjected to histological review, image analysis, and DNA methylation studies. Tumor group-specific methylation profiles and copy number variation (CNV) profiles were established for all gliomas. Algorithms for automated CNV analysis were developed. All tumors exhibiting 1p/19q codeletion were excluded from the series. We developed algorithms for grading, based on molecular, morphological and clinical data. Performance of these algorithms was compared with that of WHO grading. Three independent cohorts of 108, 154 and 224 IDH-mutant astrocytic gliomas were used to validate this approach. In the discovery cohort several molecular and clinical parameters were of prognostic relevance. Most relevant for overall survival (OS) was CDKN2A/B homozygous deletion. Other parameters with major influence were necrosis and the total number of CNV. Proliferation as assessed by mitotic count, which is a key parameter in 2016 CNS WHO grading, was of only minor influence. Employing the parameters most relevant for OS in our discovery set, we developed two models for grading these tumors. These models performed significantly better than WHO grading in both the discovery and the validation sets. Our novel algorithms for grading IDH-mutant astrocytic gliomas overcome the challenges caused by introduction of IDH status into the WHO classification of diffuse astrocytic tumors. We propose that these revised approaches be used for grading of these tumors and incorporated into future WHO criteria.
      datePublished:2018-04-23T00:00:00Z
      dateModified:2018-04-23T00:00:00Z
      pageStart:153
      pageEnd:166
      sameAs:https://doi.org/10.1007/s00401-018-1849-4
      keywords:
         Astrocytoma
         Glioblastoma
         IDH
         Grading
         CDKN2A/B
         Pathology
         Neurosciences
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      isPartOf:
         name:Acta Neuropathologica
         issn:
            1432-0533
            0001-6322
         volumeNumber:136
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            Periodical
            PublicationVolume
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
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      author:
            name:Mitsuaki Shirahata
            affiliation:
                  name:Heidelberg University Hospital
                  address:
                     name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Saitama Medical University International Medical Center
                  address:
                     name:Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Takahiro Ono
            affiliation:
                  name:Heidelberg University Hospital
                  address:
                     name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Akita University Graduate School of Medicine
                  address:
                     name:Department of Neurosurgery, Akita University Graduate School of Medicine, Akita, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Damian Stichel
            affiliation:
                  name:German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
                  address:
                     name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Daniel Schrimpf
            affiliation:
                  name:Heidelberg University Hospital
                  address:
                     name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
                  address:
                     name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:David E. Reuss
            affiliation:
                  name:Heidelberg University Hospital
                  address:
                     name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
                  address:
                     name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Felix Sahm
            affiliation:
                  name:Heidelberg University Hospital
                  address:
                     name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
                  address:
                     name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Christian Koelsche
            affiliation:
                  name:Heidelberg University Hospital
                  address:
                     name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
                  address:
                     name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Annika Wefers
            affiliation:
                  name:Heidelberg University Hospital
                  address:
                     name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
                  address:
                     name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Annekathrin Reinhardt
            affiliation:
                  name:Heidelberg University Hospital
                  address:
                     name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
                  address:
                     name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kristin Huang
            affiliation:
                  name:Heidelberg University Hospital
                  address:
                     name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
                  address:
                     name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
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            type:Person
            name:Philipp Sievers
            affiliation:
                  name:Heidelberg University Hospital
                  address:
                     name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
                  address:
                     name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
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            type:Person
            name:Hiroaki Shimizu
            affiliation:
                  name:Akita University Graduate School of Medicine
                  address:
                     name:Department of Neurosurgery, Akita University Graduate School of Medicine, Akita, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hiroshi Nanjo
            affiliation:
                  name:Akita University Hospital Division of Clinical Pathology
                  address:
                     name:Akita University Hospital Division of Clinical Pathology, Akita, Japan
                     type:PostalAddress
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                  name:Medical Center
                  address:
                     name:Medical Center, Hidaka, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yusuke Kobayashi
            affiliation:
                  name:Saitama Medical University International Medical Center
                  address:
                     name:Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yohei Miyake
            affiliation:
                  name:Saitama Medical University International Medical Center
                  address:
                     name:Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Tomonari Suzuki
            affiliation:
                  name:Saitama Medical University International Medical Center
                  address:
                     name:Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jun-ichi Adachi
            affiliation:
                  name:Saitama Medical University International Medical Center
                  address:
                     name:Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kazuhiko Mishima
            affiliation:
                  name:Saitama Medical University International Medical Center
                  address:
                     name:Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Atsushi Sasaki
            affiliation:
                  name:Saitama Medical University International Medical Center
                  address:
                     name:Department of Pathology, Saitama Medical University International Medical Center, Hidaka, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ryo Nishikawa
            affiliation:
                  name:Saitama Medical University International Medical Center
                  address:
                     name:Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Melanie Bewerunge-Hudler
            affiliation:
                  name:Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ)
                  address:
                     name:Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marina Ryzhova
            affiliation:
                  name:NN Burdenko Neurosurgical Institute
                  address:
                     name:NN Burdenko Neurosurgical Institute, Moscow, Russia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Oksana Absalyamova
            affiliation:
                  name:NN Burdenko Neurosurgical Institute
                  address:
                     name:NN Burdenko Neurosurgical Institute, Moscow, Russia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Andrey Golanov
            affiliation:
                  name:NN Burdenko Neurosurgical Institute
                  address:
                     name:NN Burdenko Neurosurgical Institute, Moscow, Russia
                     type:PostalAddress
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            type:Person
            name:Peter Sinn
            affiliation:
                  name:University Hospital Heidelberg
                  address:
                     name:Department of Pathology, University Hospital Heidelberg, Heidelberg, Germany
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            type:Person
            name:Michael Platten
            affiliation:
                  name:Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University
                  address:
                     name:Department of Neurology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Christine Jungk
            affiliation:
                  name:Heidelberg University Hospital
                  address:
                     name:Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Frank Winkler
            affiliation:
                  name:Heidelberg University Hospital
                  address:
                     name:Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
                  address:
                     name:Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Antje Wick
            affiliation:
                  name:Heidelberg University Hospital
                  address:
                     name:Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
                  address:
                     name:Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Daniel Hänggi
            affiliation:
                  name:University Medical Center Mannheim, University of Heidelberg
                  address:
                     name:Department of Neurosurgery, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Andreas Unterberg
            affiliation:
                  name:Heidelberg University Hospital
                  address:
                     name:Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Stefan M. Pfister
            affiliation:
                  name:Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
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                     name:Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
                  address:
                     name:Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:University Hospital Heidelberg
                  address:
                     name:Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:David T. W. Jones
            affiliation:
                  name:Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
                  address:
                     name:Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
                  address:
                     name:Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Martin van den Bent
            affiliation:
                  name:The Brain Tumor Center at Erasmus MC Cancer Institute
                  address:
                     name:The Brain Tumor Center at Erasmus MC Cancer Institute, Rotterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Monika Hegi
            affiliation:
                  name:Lausanne University Hospital
                  address:
                     name:Laboratory of Brain Tumor Biology and Genetics, Neuroscience Research Center, Lausanne University Hospital, Lausanne, Switzerland
                     type:PostalAddress
                  type:Organization
                  name:Lausanne University Hospital
                  address:
                     name:Division of Neurosurgery, Lausanne University Hospital, Lausanne, Switzerland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Pim French
            affiliation:
                  name:The Brain Tumor Center at Erasmus MC Cancer Institute
                  address:
                     name:The Brain Tumor Center at Erasmus MC Cancer Institute, Rotterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Brigitta G. Baumert
            affiliation:
                  name:Maastricht University Medical Centre
                  address:
                     name:Department of Radiation-Oncology (MAASTRO Clinic) and GROW (School for Oncology), Maastricht University Medical Centre, Maastricht, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Roger Stupp
            affiliation:
                  name:Northwestern University Feinberg School of Medicine
                  address:
                     name:Malnati Brain Tumor Institute of the Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Thierry Gorlia
            affiliation:
                  name:EORTC Headquarter
                  address:
                     name:EORTC Headquarter, Brussels, Belgium
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Michael Weller
            affiliation:
                  name:University Hospital and University of Zurich
                  address:
                     name:Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:David Capper
            affiliation:
                  name:Heidelberg University Hospital
                  address:
                     name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ) Heidelberg
                  address:
                     name:German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ) Heidelberg, Berlin, Germany
                     type:PostalAddress
                  type:Organization
                  name:Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin
                  address:
                     name:Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany
                     type:PostalAddress
                  type:Organization
                  name:Berlin Institute of Health
                  address:
                     name:Department of Neuropathology, Berlin Institute of Health, Berlin, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Andrey Korshunov
            affiliation:
                  name:Heidelberg University Hospital
                  address:
                     name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
                  address:
                     name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Christel Herold-Mende
            affiliation:
                  name:Heidelberg University Hospital
                  address:
                     name:Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wolfgang Wick
            affiliation:
                  name:Heidelberg University Hospital
                  address:
                     name:Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
                  address:
                     name:Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:David N. Louis
            affiliation:
                  name:Massachusetts General Hospital and Harvard Medical School
                  address:
                     name:Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Andreas von Deimling
            affiliation:
                  name:Heidelberg University Hospital
                  address:
                     name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
                  address:
                     name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:University of Heidelberg and DKFZ
                  address:
                     name:Department for Neuropathology and CCU Neuropathology, University of Heidelberg and DKFZ, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            email:[email protected]
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      name:Acta Neuropathologica
      issn:
         1432-0533
         0001-6322
      volumeNumber:136
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      name:Springer Berlin Heidelberg
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      name:Heidelberg University Hospital
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         name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
         type:PostalAddress
      name:Saitama Medical University International Medical Center
      address:
         name:Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Japan
         type:PostalAddress
      name:Heidelberg University Hospital
      address:
         name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
         type:PostalAddress
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            address:
               name:Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:David T. W. Jones
      affiliation:
            name:Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
            address:
               name:Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
            address:
               name:Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Martin van den Bent
      affiliation:
            name:The Brain Tumor Center at Erasmus MC Cancer Institute
            address:
               name:The Brain Tumor Center at Erasmus MC Cancer Institute, Rotterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Monika Hegi
      affiliation:
            name:Lausanne University Hospital
            address:
               name:Laboratory of Brain Tumor Biology and Genetics, Neuroscience Research Center, Lausanne University Hospital, Lausanne, Switzerland
               type:PostalAddress
            type:Organization
            name:Lausanne University Hospital
            address:
               name:Division of Neurosurgery, Lausanne University Hospital, Lausanne, Switzerland
               type:PostalAddress
            type:Organization
      name:Pim French
      affiliation:
            name:The Brain Tumor Center at Erasmus MC Cancer Institute
            address:
               name:The Brain Tumor Center at Erasmus MC Cancer Institute, Rotterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Brigitta G. Baumert
      affiliation:
            name:Maastricht University Medical Centre
            address:
               name:Department of Radiation-Oncology (MAASTRO Clinic) and GROW (School for Oncology), Maastricht University Medical Centre, Maastricht, The Netherlands
               type:PostalAddress
            type:Organization
      name:Roger Stupp
      affiliation:
            name:Northwestern University Feinberg School of Medicine
            address:
               name:Malnati Brain Tumor Institute of the Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, USA
               type:PostalAddress
            type:Organization
      name:Thierry Gorlia
      affiliation:
            name:EORTC Headquarter
            address:
               name:EORTC Headquarter, Brussels, Belgium
               type:PostalAddress
            type:Organization
      name:Michael Weller
      affiliation:
            name:University Hospital and University of Zurich
            address:
               name:Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland
               type:PostalAddress
            type:Organization
      name:David Capper
      affiliation:
            name:Heidelberg University Hospital
            address:
               name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ) Heidelberg
            address:
               name:German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ) Heidelberg, Berlin, Germany
               type:PostalAddress
            type:Organization
            name:Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin
            address:
               name:Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany
               type:PostalAddress
            type:Organization
            name:Berlin Institute of Health
            address:
               name:Department of Neuropathology, Berlin Institute of Health, Berlin, Germany
               type:PostalAddress
            type:Organization
      name:Andrey Korshunov
      affiliation:
            name:Heidelberg University Hospital
            address:
               name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
            address:
               name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Christel Herold-Mende
      affiliation:
            name:Heidelberg University Hospital
            address:
               name:Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Wolfgang Wick
      affiliation:
            name:Heidelberg University Hospital
            address:
               name:Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
            address:
               name:Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:David N. Louis
      affiliation:
            name:Massachusetts General Hospital and Harvard Medical School
            address:
               name:Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Andreas von Deimling
      affiliation:
            name:Heidelberg University Hospital
            address:
               name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
            address:
               name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:University of Heidelberg and DKFZ
            address:
               name:Department for Neuropathology and CCU Neuropathology, University of Heidelberg and DKFZ, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
      name:Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Japan
      name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
      name:Department of Neurosurgery, Akita University Graduate School of Medicine, Akita, Japan
      name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
      name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
      name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
      name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
      name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
      name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
      name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
      name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
      name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Neurosurgery, Akita University Graduate School of Medicine, Akita, Japan
      name:Akita University Hospital Division of Clinical Pathology, Akita, Japan
      name:Medical Center, Hidaka, Japan
      name:Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Japan
      name:Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Japan
      name:Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Japan
      name:Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Japan
      name:Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Japan
      name:Department of Pathology, Saitama Medical University International Medical Center, Hidaka, Japan
      name:Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Japan
      name:Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:NN Burdenko Neurosurgical Institute, Moscow, Russia
      name:NN Burdenko Neurosurgical Institute, Moscow, Russia
      name:NN Burdenko Neurosurgical Institute, Moscow, Russia
      name:Department of Pathology, University Hospital Heidelberg, Heidelberg, Germany
      name:Department of Neurology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
      name:Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany
      name:Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany
      name:Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany
      name:Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Neurosurgery, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
      name:Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany
      name:Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany
      name:Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, Heidelberg, Germany
      name:Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany
      name:Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:The Brain Tumor Center at Erasmus MC Cancer Institute, Rotterdam, The Netherlands
      name:Laboratory of Brain Tumor Biology and Genetics, Neuroscience Research Center, Lausanne University Hospital, Lausanne, Switzerland
      name:Division of Neurosurgery, Lausanne University Hospital, Lausanne, Switzerland
      name:The Brain Tumor Center at Erasmus MC Cancer Institute, Rotterdam, The Netherlands
      name:Department of Radiation-Oncology (MAASTRO Clinic) and GROW (School for Oncology), Maastricht University Medical Centre, Maastricht, The Netherlands
      name:Malnati Brain Tumor Institute of the Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, USA
      name:EORTC Headquarter, Brussels, Belgium
      name:Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland
      name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
      name:German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ) Heidelberg, Berlin, Germany
      name:Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany
      name:Department of Neuropathology, Berlin Institute of Health, Berlin, Germany
      name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
      name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany
      name:Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany
      name:Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
      name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
      name:Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department for Neuropathology and CCU Neuropathology, University of Heidelberg and DKFZ, Heidelberg, Germany
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