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Title:
Sialoadhesin in recognition of self and non-self | Seminars in Immunopathology
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The immune system is tightly regulated to maintain an appropriate balance between immune activation and tolerance. Macrophages play a key role in this process since they express many pathogen recognition molecules as well as receptors for ‘self’. Sialoadhesin is a major macrophage receptor that specifically recognizes sialic acid, an abundant component of host glycoconjugates but which can also be found on several human pathogens. In recent years, several studies have demonstrated that sialoadhesin can contribute to the uptake and processing of sialylated pathogens as well as playing an important role in regulating inflammatory and autoimmune responses via recognition of self.
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article, google, scholar, pubmed, cas, crocker, sialoadhesin, van, sialic, mϕs, receptor, porcine, cells, cell, syndrome, nauwynck, immune, reproductive, respiratory, virus, immunity, immunol, virol, gordon, binding, kelm, delputte, recognition, acid, siglecs, expressed, receptors, human, sialylated, acidbinding, acids, jones, privacy, cookies, content, campylobacter, jejuni, lymph, plos, biol, mol, analysis, information, publish, search,
Topics {✒️}
month download article/chapter sialic acid-binding activity sialic acid-binding receptor sialic acid-dependent manner sialic acid-binding site sialic acid–binding immunoglobulin sialic acid-binding immunoglobulin streptavidin-based neoglycoprotein carrying related alpha-keto acids sialic-acid binding lectins species-restricted serum factor mϕ-hematopoietic cell clusters cd163-positive early endosomes blood–brain barrier regulates mϕ-specific receptor sialoadhesin article klaas full article pdf b-cell lymphoma n-terminal immunoglobulin domain pathogen recognition molecules innate immune system viral sialic acids respiratory syndrome viruses protein sorting receptors sialic acids involved privacy choices/manage cookies hematopoietic cell clusters mouse mϕ hemagglutinin mice heterozygously deficient respiratory syndrome virus human rhinoviruses inhibit regulate innate inflammatory mϕ populations murine mϕ haemagglutinin author correspondence van den burg major macrophage receptor crosspresenting dead cell sheep erythrocyte receptor epithelial cell invasion t-cell populations mϕ-rich area murine tissue mϕs plp overexpressing mice hemagglutinin differentially expressed cd163 join forces van doorn pa van woensel pa sialic acid delputte pl
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headline:Sialoadhesin in recognition of self and non-self
description:The immune system is tightly regulated to maintain an appropriate balance between immune activation and tolerance. Macrophages play a key role in this process since they express many pathogen recognition molecules as well as receptors for ‘self’. Sialoadhesin is a major macrophage receptor that specifically recognizes sialic acid, an abundant component of host glycoconjugates but which can also be found on several human pathogens. In recent years, several studies have demonstrated that sialoadhesin can contribute to the uptake and processing of sialylated pathogens as well as playing an important role in regulating inflammatory and autoimmune responses via recognition of self.
datePublished:2012-03-27T00:00:00Z
dateModified:2012-03-27T00:00:00Z
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Sialic acid
Innate immunity
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Immunology
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