We are analyzing https://link.springer.com/article/10.1007/s002620050415.

Title:
Tumor-specific T-bodies: towards clinical application | Cancer Immunology, Immunotherapy
Description:
Unlike antibodies, T cells are well suited to penetrate and destroy solid tumors. The T-body approach combines antibody recognition and T cells effector function. It is based on T cells expressing chimeric receptors composed of antibody-derived Fv or scFv as their extracellular recognition elements joined to lymphocyte triggering molecules. This receptors can redirect the specificity of T cells in an MHC independent manner. Upon encountering their target cells, T-bodies are able to undergo specific stimulation for interleukin/cytokine production, and kill hapten-modified or tumor cells in model systems both in vitro and in vivo. T cells expressing chimeric receptors made of antitumor antibodies are able to discriminate between a tumor and normal cell with negligible bystander cytotoxicity. Further studies should be carried out to evaluate and optimize the persistence, homing patterns and reactivation potential of T-bodies in the body.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

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Topics {✒️}

tumor-specific t-bodies access tumor-specific t-bodies month download article/chapter 2024 t-cell immunotherapy antibody-derived fv privacy choices/manage cookies article cancer immunology undergo specific stimulation full article pdf cell therapy article eshhar european economic area destroy solid tumors lymphocyte triggering molecules mhc independent manner interleukin/cytokine production negligible bystander cytotoxicity related subjects conditions privacy policy kill hapten-modified t-bodies cells effector function accepting optional cookies journal finder publish antitumor antibodies clinical application tumor cells normal cell check access instant access article log privacy policy personal data immunotherapy aims books a therapy target cells optional cookies manage preferences november 1997 volume 45 article cite subscription content similar content data protection essential cookies cookies skip institution subscribe journal publish usage analysis social media

Schema {🗺️}

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         description: Unlike antibodies, T cells are well suited to penetrate and destroy solid tumors. The T-body approach combines antibody recognition and T cells effector function. It is based on T cells expressing chimeric receptors composed of antibody-derived Fv or scFv as their extracellular recognition elements joined to lymphocyte triggering molecules. This receptors can redirect the specificity of T cells in an MHC independent manner. Upon encountering their target cells, T-bodies are able to undergo specific stimulation for interleukin/cytokine production, and kill hapten-modified or tumor cells in model systems both in vitro and in vivo. T cells expressing chimeric receptors made of antitumor antibodies are able to discriminate between a tumor and normal cell with negligible bystander cytotoxicity. Further studies should be carried out to evaluate and optimize the persistence, homing patterns and reactivation potential of T-bodies in the body.
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