We are analyzing https://link.springer.com/article/10.1007/s00262-006-0237-4.

Title:
In the FVB/N HER-2/neu transgenic mouse both peripheral and central tolerance limit the immune response targeting HER-2/neu induced by Listeria monocytogenes-based vaccines | Cancer Immunology, Immunotherapy
Description:
Listeria monocytogenes-based vaccines for HER-2/neu are capable of breaking tolerance in FVB/N rat HER-2/neu transgenic mice. The growth of implanted NT-2 tumors, derived from a spontaneously occurring tumor in the FVB/N HER-2/neu transgenic mouse, was significantly slower in these mice following vaccination with a series of L. monocytogenes-based vaccines for HER-2/neu. Mechanisms of T cell tolerance that exist in these transgenic mice include the absence of functional high avidity anti-HER-2/neu CD8+ T cells and the presence of CD4+CD25+ regulatory T cells. The in vivo depletion of these regulatory T cells resulted in the slowing in growth of tumors even without the treatment of mice with an anti-HER-2/neu vaccine. The average avidities of responsive CD8+ T cells to six of the nine epitopes in HER-2/neu we examined, four of which were identified in this study, are shown here to be of a lower average avidity in the transgenic mice versus wild type FVB/N mice. In contrast, the average avidity of CD8+ T cells to three epitopes that showed the lowest avidity in the wild-type mice did not differ between wild type and transgenic mice. This study demonstrates the ability of L. monocytogenes-based vaccines to impact upon tolerance to HER-2/neu in FVB/N HER-2/neu transgenic mice and further defines some of the aspects of tolerance in these mice.
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Keywords {🔍}

pubmed, google, scholar, cas, article, cancer, herneu, mice, immunol, cell, cells, transgenic, tolerance, breast, paterson, tumor, res, regulatory, fvbn, immune, listeria, vaccine, human, mouse, vaccines, vaccination, access, antitumor, immunity, immunotherapy, avidity, epitopes, med, mammary, jaffee, university, pennsylvania, privacy, cookies, content, response, induced, monocytogenesbased, singh, tumors, cdcd, epitope, int, disis, murine,

Topics {✒️}

antigen co17-1a/ga733 encoded lm-llo-ny-eso-1 prior month download article/chapter e6/e7-transgenic mice human papilloma virus-16 listeria monocytogenes-based vaccines anti-tumor immune responses related subjects mhc–peptide–tcr complex antigen-specific antibodies elicited encode tumor-specific antigens early-stage breast cancer dominant regulatory t-cell 2/neu protein-specific antibody therapeutic t-cell responses article cancer immunology monocytogenes-based vaccines cd8+ t-cell epitopes murine mhc class monoclonal antibodies specific wild-type mice full article pdf h-2l genes arose listeria monocytogenes enhances article singh murine mammary gland advanced colorectal cancer 2/neu mhc class privacy choices/manage cookies antitumor immune response human breast cancer antigen-specific immunotherapy monoclonal antibodies reactive her2 dna delivered e7 induce qualitatively yvonne paterson wishes existent t-cell central tolerance limit human colorectal cancer antitumor activity adenovirus inhibits growth reveals subdominant epitopes wild type primary systemic therapy zhen-kun pan functional effects high-avidity cd8 active-specific immunotherapy disis ml spontaneously occurring tumor

Questions {❓}

Lenahan C, Dennis C, Isakovich NV, Pories SE (2005) Breast cancer: what’s HER-2/neu got to do with it?

Schema {🗺️}

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      headline:In the FVB/N HER-2/neu transgenic mouse both peripheral and central tolerance limit the immune response targeting HER-2/neu induced by Listeria monocytogenes-based vaccines
      description: Listeria monocytogenes-based vaccines for HER-2/neu are capable of breaking tolerance in FVB/N rat HER-2/neu transgenic mice. The growth of implanted NT-2 tumors, derived from a spontaneously occurring tumor in the FVB/N HER-2/neu transgenic mouse, was significantly slower in these mice following vaccination with a series of L. monocytogenes-based vaccines for HER-2/neu. Mechanisms of T cell tolerance that exist in these transgenic mice include the absence of functional high avidity anti-HER-2/neu CD8+ T cells and the presence of CD4+CD25+ regulatory T cells. The in vivo depletion of these regulatory T cells resulted in the slowing in growth of tumors even without the treatment of mice with an anti-HER-2/neu vaccine. The average avidities of responsive CD8+ T cells to six of the nine epitopes in HER-2/neu we examined, four of which were identified in this study, are shown here to be of a lower average avidity in the transgenic mice versus wild type FVB/N mice. In contrast, the average avidity of CD8+ T cells to three epitopes that showed the lowest avidity in the wild-type mice did not differ between wild type and transgenic mice. This study demonstrates the ability of L. monocytogenes-based vaccines to impact upon tolerance to HER-2/neu in FVB/N HER-2/neu transgenic mice and further defines some of the aspects of tolerance in these mice.
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