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Title:
Partial volume effect-corrected FDG PET and grey matter volume loss in patients with mild Alzheimerās disease | European Journal of Nuclear Medicine and Molecular Imaging
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Purpose Although 18F-fluorodeoxyglucose (FDG) PET is an established imaging technique to assess brain glucose utilisation, accurate measurement of tracer concentration is confounded by the presence of partial volume effect (PVE) due to the limited spatial resolution of PET, which is particularly true in atrophic brains such as those encountered in patients with Alzheimerās disease (AD). Our aim was to investigate the effects of PVE correction on FDG PET in conjunction with voxel-based morphometry (VBM) in patients with mild AD. Methods Thirty-nine AD patients and 73 controls underwent FDG PET and MRI. The PVE-corrected grey matter PET images were obtained using an MRI-based three-compartment method. Additionally, the results of PET were compared with grey matter loss detected by VBM. Results Before PVE correction, reduced FDG uptake was observed in posterior cingulate gyri (PCG) and parieto-temporal lobes (PTL) in AD patients, which persisted after PVE correction. Notably, PVE correction revealed relatively preserved FDG uptake in hippocampal areas, despite the grey matter loss in medial temporal lobe (MTL) revealed by VBM. Conclusion FDG uptake in PCG and PTL is reduced in AD regardless of whether or not PVE correction is applied, supporting the notion that the reduced FDG uptake in these areas is not the result of atrophy. Furthermore, FDG uptake by grey matter tissue in the MTL, including hippocampal areas, is relatively preserved, suggesting that compensatory mechanisms may play a role in patients with mild AD.
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google, scholar, article, pubmed, disease, alzheimers, cas, pet, imaging, fdg, hippocampal, nucl, med, patients, mild, brain, correction, neurology, volume, matter, loss, glucose, pve, access, study, eur, metabolism, content, grey, matsunari, uptake, medical, alzheimer, neuroimage, mol, diagnosis, japan, privacy, cookies, journal, research, chen, voxelbased, atrophy, metabolic, cortex, neurol, dementia, impairment, aging,
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positron emission tomography 99mtc-hmpao-spect images month download article/chapter daisuke yanaseĀ &Ā masahito yamada brain 18f-fdg pet functional imaging patterns early-phase [18f]florbetapir nincds-adrda work group molecular imaging aims cell-specific pathology isolates optimized voxel-based morphometry related subjects voxel-based morphometric study partial volume effect 18f-fdg pet article european journal simultaneous pet/mri established imaging technique full article pdf partial volume averaging de leon mj privacy choices/manage cookies fdg-pet studies voxel-based morphometry voxel-based morphometry multicenter fdg pet grey matter loss partial-volume effects grey matter tissue cortical synaptic density european economic area medial temporal lobe cerebellar glucose metabolism altered glucose metabolism brain glucose metabolism kanazawa university hospital preserved fdg uptake knowledge handling technology gray matter loss brain perfusion spect reduced fdg uptake quantitative morphometric analysis mild cognitive impairment article samuraki limited spatial resolution posterior cingulate gyri parieto-temporal lobes functional connectivity rapid scanning protocol van schijndel ra
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headline:Partial volume effect-corrected FDG PET and grey matter volume loss in patients with mild Alzheimerās disease
description:Although 18F-fluorodeoxyglucose (FDG) PET is an established imaging technique to assess brain glucose utilisation, accurate measurement of tracer concentration is confounded by the presence of partial volume effect (PVE) due to the limited spatial resolution of PET, which is particularly true in atrophic brains such as those encountered in patients with Alzheimerās disease (AD). Our aim was to investigate the effects of PVE correction on FDG PET in conjunction with voxel-based morphometry (VBM) in patients with mild AD. Thirty-nine AD patients and 73 controls underwent FDG PET and MRI. The PVE-corrected grey matter PET images were obtained using an MRI-based three-compartment method. Additionally, the results of PET were compared with grey matter loss detected by VBM. Before PVE correction, reduced FDG uptake was observed in posterior cingulate gyri (PCG) and parieto-temporal lobes (PTL) in AD patients, which persisted after PVE correction. Notably, PVE correction revealed relatively preserved FDG uptake in hippocampal areas, despite the grey matter loss in medial temporal lobe (MTL) revealed by VBM. FDG uptake in PCG and PTL is reduced in AD regardless of whether or not PVE correction is applied, supporting the notion that the reduced FDG uptake in these areas is not the result of atrophy. Furthermore, FDG uptake by grey matter tissue in the MTL, including hippocampal areas, is relatively preserved, suggesting that compensatory mechanisms may play a role in patients with mild AD.
datePublished:2007-05-23T00:00:00Z
dateModified:2007-05-23T00:00:00Z
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Alzheimerās disease
FDG
PVE
Cortical atrophy
Hippocampus
Nuclear Medicine
Imaging / Radiology
Orthopedics
Cardiology
Oncology
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headline:Partial volume effect-corrected FDG PET and grey matter volume loss in patients with mild Alzheimerās disease
description:Although 18F-fluorodeoxyglucose (FDG) PET is an established imaging technique to assess brain glucose utilisation, accurate measurement of tracer concentration is confounded by the presence of partial volume effect (PVE) due to the limited spatial resolution of PET, which is particularly true in atrophic brains such as those encountered in patients with Alzheimerās disease (AD). Our aim was to investigate the effects of PVE correction on FDG PET in conjunction with voxel-based morphometry (VBM) in patients with mild AD. Thirty-nine AD patients and 73 controls underwent FDG PET and MRI. The PVE-corrected grey matter PET images were obtained using an MRI-based three-compartment method. Additionally, the results of PET were compared with grey matter loss detected by VBM. Before PVE correction, reduced FDG uptake was observed in posterior cingulate gyri (PCG) and parieto-temporal lobes (PTL) in AD patients, which persisted after PVE correction. Notably, PVE correction revealed relatively preserved FDG uptake in hippocampal areas, despite the grey matter loss in medial temporal lobe (MTL) revealed by VBM. FDG uptake in PCG and PTL is reduced in AD regardless of whether or not PVE correction is applied, supporting the notion that the reduced FDG uptake in these areas is not the result of atrophy. Furthermore, FDG uptake by grey matter tissue in the MTL, including hippocampal areas, is relatively preserved, suggesting that compensatory mechanisms may play a role in patients with mild AD.
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Alzheimerās disease
FDG
PVE
Cortical atrophy
Hippocampus
Nuclear Medicine
Imaging / Radiology
Orthopedics
Cardiology
Oncology
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