We are analyzing https://link.springer.com/article/10.1007/s00259-003-1441-5.

Title:
A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging | European Journal of Nuclear Medicine and Molecular Imaging
Description:
Two genetic reporter systems were developed for multimodality reporter gene imaging of different molecular-genetic processes using fluorescence, bioluminescence (BLI), and nuclear imaging techniques. The eGFP cDNA was fused at the N-terminus with HSV1-tk cDNA bearing a nuclear export signal from MAPKK (NES-HSV1-tk) or with truncation at the N-terminus of the first 45 amino acids (Δ45HSV1-tk) and with firefly luciferase at the C-terminus. A single fusion protein with three functional subunits is formed following transcription and translation from a single open reading frame. The NES-TGL (NES-TGL) or Δ45HSV1-tk/GFP/luciferase (Δ45-TGL) triple-fusion gene cDNAs were cloned into a MoMLV-based retrovirus, which was used for transduction of U87 human glioma cells. The integrity, fluorescence, bioluminescence, and enzymatic activity of the TGL reporter proteins were assessed in vitro. The predicted molecular weight of the fusion proteins (~130 kDa) was confirmed by western blot. The U87-NES-TGL and U87-Δ45-TGL cells had cytoplasmic green fluorescence. The in vitro BLI was 7- and 13-fold higher in U87-NES-TGL and U87-Δ45-TGL cells compared to nontransduced control cells. The Ki of 14C-FIAU was 0.49±0.02, 0.51±0.03, and 0.003±0.001 ml/min/g in U87-NES-TGL, U87-Δ45-TGL, and wild-type U87 cells, respectively. Multimodality in vivo imaging studies were performed in nu/nu mice bearing multiple s.c. xenografts established from U87-NES-TGL, U87-Δ45-TGL, and wild-type U87 cells. BLI was performed after administration of d-luciferin (150 mg/kg i.v.). Gamma camera or PET imaging was conducted at 2 h after i.v. administration of [131I]FIAU (7.4 MBq/animal) or [124I]FIAU (7.4 MBq/animal), respectively. Whole-body fluorescence imaging was performed in parallel with the BLI and radiotracer imaging studies. In vivo BLI and gamma camera imaging showed specific localization of luminescence and radioactivity to the TGL transduced xenografts with background levels of activity in the wild-type xenografts. Tissue sampling yielded values of 0.47%±0.08%, 0.86%±0.06%, and 0.03%±0.01%dose/g [131I]FIAU in U87-NES-TGL, U87-Δ45-TGL, and U87 xenografts, respectively. The TGL triple-fusion reporter gene preserves the functional activity of its subunits and is very effective for multimodality imaging. It provides for the seamless transition from fluorescence microscopy and FACS to whole-body bioluminescence imaging, to nuclear (PET, SPET, gamma camera) imaging, and back to in situ fluorescence image analysis.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Education
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

imaging, google, scholar, pubmed, cas, gene, article, tjuvajev, reporter, blasberg, expression, balatoni, ponomarev, thymidine, cancer, doubrovin, gelovani, virus, kinase, finn, noninvasive, cells, vivo, mice, fluorescent, beresten, green, herpes, gambhir, nuclear, serganova, simplex, med, res, molecular, protein, cell, larson, sadelain, positron, emission, tomography, ageyeva, fluorescence, human, access, nucl, living, mol, fusion,

Topics {✒️}

monitoring e-selectin-mediated adhesion month download article/chapter hsv-1 thymidine kinase u87-δ45-tgl cells compared herpes virus infection wild-type u87 cells triple-fusion gene cdnas renilla luciferase-aequorea gfp hsv1-tk cdna bearing triple-modality reporter gene δ45hsv1-tk/gfp/luciferase juri gelovani tjuvajev truncated hsv1-tk green fluorescent protein intact blood-brain barrier invasive molecular-genetic imaging protein-protein interactions u87-δ45-tgl cells single fusion protein combined pet/ct scanner red fluorescent proteins fusion reporter gene vesicular stomatitis virus article european journal wild-type xenografts full article pdf reporter gene expression genetic reporter systems nes-hsv1-tk p53-dependent genes reporter gene imaging ubiquitous green cells transgene expression mediated molecular-genetic targets author correspondence multiple reporter genes marker/reporter gene immunogenic reporter gene tgl reporter proteins privacy choices/manage cookies gelovani tjuvajev jg gene transfer strategies gene transfer studies stable gene transfer related subjects human tumor cells endogenous gene expression molecular-genetic processes tgl transduced xenografts fusion protein

Schema {🗺️}

WebPage:
      mainEntity:
         headline:A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging
         description:Two genetic reporter systems were developed for multimodality reporter gene imaging of different molecular-genetic processes using fluorescence, bioluminescence (BLI), and nuclear imaging techniques. The eGFP cDNA was fused at the N-terminus with HSV1-tk cDNA bearing a nuclear export signal from MAPKK (NES-HSV1-tk) or with truncation at the N-terminus of the first 45 amino acids (Δ45HSV1-tk) and with firefly luciferase at the C-terminus. A single fusion protein with three functional subunits is formed following transcription and translation from a single open reading frame. The NES-TGL (NES-TGL) or Δ45HSV1-tk/GFP/luciferase (Δ45-TGL) triple-fusion gene cDNAs were cloned into a MoMLV-based retrovirus, which was used for transduction of U87 human glioma cells. The integrity, fluorescence, bioluminescence, and enzymatic activity of the TGL reporter proteins were assessed in vitro. The predicted molecular weight of the fusion proteins (~130 kDa) was confirmed by western blot. The U87-NES-TGL and U87-Δ45-TGL cells had cytoplasmic green fluorescence. The in vitro BLI was 7- and 13-fold higher in U87-NES-TGL and U87-Δ45-TGL cells compared to nontransduced control cells. The Ki of 14C-FIAU was 0.49±0.02, 0.51±0.03, and 0.003±0.001 ml/min/g in U87-NES-TGL, U87-Δ45-TGL, and wild-type U87 cells, respectively. Multimodality in vivo imaging studies were performed in nu/nu mice bearing multiple s.c. xenografts established from U87-NES-TGL, U87-Δ45-TGL, and wild-type U87 cells. BLI was performed after administration of d-luciferin (150 mg/kg i.v.). Gamma camera or PET imaging was conducted at 2 h after i.v. administration of [131I]FIAU (7.4 MBq/animal) or [124I]FIAU (7.4 MBq/animal), respectively. Whole-body fluorescence imaging was performed in parallel with the BLI and radiotracer imaging studies. In vivo BLI and gamma camera imaging showed specific localization of luminescence and radioactivity to the TGL transduced xenografts with background levels of activity in the wild-type xenografts. Tissue sampling yielded values of 0.47%±0.08%, 0.86%±0.06%, and 0.03%±0.01%dose/g [131I]FIAU in U87-NES-TGL, U87-Δ45-TGL, and U87 xenografts, respectively. The TGL triple-fusion reporter gene preserves the functional activity of its subunits and is very effective for multimodality imaging. It provides for the seamless transition from fluorescence microscopy and FACS to whole-body bioluminescence imaging, to nuclear (PET, SPET, gamma camera) imaging, and back to in situ fluorescence image analysis.
         datePublished:2004-03-11T00:00:00Z
         dateModified:2004-03-11T00:00:00Z
         pageStart:740
         pageEnd:751
         sameAs:https://doi.org/10.1007/s00259-003-1441-5
         keywords:
            Molecular imaging
            Multimodality imaging
            Herpes virus type one
            Thymidine kinase
            Green fluorescent protein
            Luciferase
            FIAU
            Nuclear Medicine
            Imaging / Radiology
            Orthopedics
            Cardiology
            Oncology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00259-003-1441-5/MediaObjects/s00259-003-1441-5flc1a-e.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00259-003-1441-5/MediaObjects/s00259-003-1441-5fhc2a-d.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00259-003-1441-5/MediaObjects/s00259-003-1441-5fhc3a-d.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00259-003-1441-5/MediaObjects/s00259-003-1441-5fhb4a-c.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00259-003-1441-5/MediaObjects/s00259-003-1441-5flb5a-d.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00259-003-1441-5/MediaObjects/s00259-003-1441-5fhc6a-c.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00259-003-1441-5/MediaObjects/s00259-003-1441-5fhc7a-c.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00259-003-1441-5/MediaObjects/s00259-003-1441-5fhc8a-d.jpg
         isPartOf:
            name:European Journal of Nuclear Medicine and Molecular Imaging
            issn:
               1619-7089
               1619-7070
            volumeNumber:31
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Vladimir Ponomarev
               affiliation:
                     name:Memorial Sloan Kettering Cancer Center
                     address:
                        name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Michael Doubrovin
               affiliation:
                     name:Memorial Sloan-Kettering Cancer Center
                     address:
                        name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Inna Serganova
               affiliation:
                     name:Memorial Sloan-Kettering Cancer Center
                     address:
                        name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jelena Vider
               affiliation:
                     name:Memorial Sloan Kettering Cancer Center
                     address:
                        name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Aleksander Shavrin
               affiliation:
                     name:Memorial Sloan Kettering Cancer Center
                     address:
                        name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Tatiana Beresten
               affiliation:
                     name:Memorial Sloan-Kettering Cancer Center
                     address:
                        name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Anna Ivanova
               affiliation:
                     name:Memorial Sloan-Kettering Cancer Center
                     address:
                        name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ludmila Ageyeva
               affiliation:
                     name:Memorial Sloan Kettering Cancer Center
                     address:
                        name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Vilia Tourkova
               affiliation:
                     name:Memorial Sloan Kettering Cancer Center
                     address:
                        name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Julius Balatoni
               affiliation:
                     name:Memorial Sloan-Kettering Cancer Center
                     address:
                        name:Radiochemistry/Cyclotron Core Facility, Memorial Sloan-Kettering Cancer Center, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:William Bornmann
               affiliation:
                     name:Memorial Sloan-Kettering Cancer Center
                     address:
                        name:Organic Chemistry Synthesis Core Facility, Memorial Sloan-Kettering Cancer Center, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ronald Blasberg
               affiliation:
                     name:Memorial Sloan-Kettering Cancer Center
                     address:
                        name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Juri Gelovani Tjuvajev
               affiliation:
                     name:Memorial Sloan Kettering Cancer Center
                     address:
                        name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
                        type:PostalAddress
                     type:Organization
                     name:MD Anderson Cancer Center
                     address:
                        name:MD Anderson Cancer Center, Houston, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging
      description:Two genetic reporter systems were developed for multimodality reporter gene imaging of different molecular-genetic processes using fluorescence, bioluminescence (BLI), and nuclear imaging techniques. The eGFP cDNA was fused at the N-terminus with HSV1-tk cDNA bearing a nuclear export signal from MAPKK (NES-HSV1-tk) or with truncation at the N-terminus of the first 45 amino acids (Δ45HSV1-tk) and with firefly luciferase at the C-terminus. A single fusion protein with three functional subunits is formed following transcription and translation from a single open reading frame. The NES-TGL (NES-TGL) or Δ45HSV1-tk/GFP/luciferase (Δ45-TGL) triple-fusion gene cDNAs were cloned into a MoMLV-based retrovirus, which was used for transduction of U87 human glioma cells. The integrity, fluorescence, bioluminescence, and enzymatic activity of the TGL reporter proteins were assessed in vitro. The predicted molecular weight of the fusion proteins (~130 kDa) was confirmed by western blot. The U87-NES-TGL and U87-Δ45-TGL cells had cytoplasmic green fluorescence. The in vitro BLI was 7- and 13-fold higher in U87-NES-TGL and U87-Δ45-TGL cells compared to nontransduced control cells. The Ki of 14C-FIAU was 0.49±0.02, 0.51±0.03, and 0.003±0.001 ml/min/g in U87-NES-TGL, U87-Δ45-TGL, and wild-type U87 cells, respectively. Multimodality in vivo imaging studies were performed in nu/nu mice bearing multiple s.c. xenografts established from U87-NES-TGL, U87-Δ45-TGL, and wild-type U87 cells. BLI was performed after administration of d-luciferin (150 mg/kg i.v.). Gamma camera or PET imaging was conducted at 2 h after i.v. administration of [131I]FIAU (7.4 MBq/animal) or [124I]FIAU (7.4 MBq/animal), respectively. Whole-body fluorescence imaging was performed in parallel with the BLI and radiotracer imaging studies. In vivo BLI and gamma camera imaging showed specific localization of luminescence and radioactivity to the TGL transduced xenografts with background levels of activity in the wild-type xenografts. Tissue sampling yielded values of 0.47%±0.08%, 0.86%±0.06%, and 0.03%±0.01%dose/g [131I]FIAU in U87-NES-TGL, U87-Δ45-TGL, and U87 xenografts, respectively. The TGL triple-fusion reporter gene preserves the functional activity of its subunits and is very effective for multimodality imaging. It provides for the seamless transition from fluorescence microscopy and FACS to whole-body bioluminescence imaging, to nuclear (PET, SPET, gamma camera) imaging, and back to in situ fluorescence image analysis.
      datePublished:2004-03-11T00:00:00Z
      dateModified:2004-03-11T00:00:00Z
      pageStart:740
      pageEnd:751
      sameAs:https://doi.org/10.1007/s00259-003-1441-5
      keywords:
         Molecular imaging
         Multimodality imaging
         Herpes virus type one
         Thymidine kinase
         Green fluorescent protein
         Luciferase
         FIAU
         Nuclear Medicine
         Imaging / Radiology
         Orthopedics
         Cardiology
         Oncology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00259-003-1441-5/MediaObjects/s00259-003-1441-5flc1a-e.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00259-003-1441-5/MediaObjects/s00259-003-1441-5fhc2a-d.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00259-003-1441-5/MediaObjects/s00259-003-1441-5fhc3a-d.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00259-003-1441-5/MediaObjects/s00259-003-1441-5fhb4a-c.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00259-003-1441-5/MediaObjects/s00259-003-1441-5flb5a-d.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00259-003-1441-5/MediaObjects/s00259-003-1441-5fhc6a-c.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00259-003-1441-5/MediaObjects/s00259-003-1441-5fhc7a-c.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00259-003-1441-5/MediaObjects/s00259-003-1441-5fhc8a-d.jpg
      isPartOf:
         name:European Journal of Nuclear Medicine and Molecular Imaging
         issn:
            1619-7089
            1619-7070
         volumeNumber:31
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Vladimir Ponomarev
            affiliation:
                  name:Memorial Sloan Kettering Cancer Center
                  address:
                     name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Michael Doubrovin
            affiliation:
                  name:Memorial Sloan-Kettering Cancer Center
                  address:
                     name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Inna Serganova
            affiliation:
                  name:Memorial Sloan-Kettering Cancer Center
                  address:
                     name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jelena Vider
            affiliation:
                  name:Memorial Sloan Kettering Cancer Center
                  address:
                     name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Aleksander Shavrin
            affiliation:
                  name:Memorial Sloan Kettering Cancer Center
                  address:
                     name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Tatiana Beresten
            affiliation:
                  name:Memorial Sloan-Kettering Cancer Center
                  address:
                     name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Anna Ivanova
            affiliation:
                  name:Memorial Sloan-Kettering Cancer Center
                  address:
                     name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ludmila Ageyeva
            affiliation:
                  name:Memorial Sloan Kettering Cancer Center
                  address:
                     name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Vilia Tourkova
            affiliation:
                  name:Memorial Sloan Kettering Cancer Center
                  address:
                     name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Julius Balatoni
            affiliation:
                  name:Memorial Sloan-Kettering Cancer Center
                  address:
                     name:Radiochemistry/Cyclotron Core Facility, Memorial Sloan-Kettering Cancer Center, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:William Bornmann
            affiliation:
                  name:Memorial Sloan-Kettering Cancer Center
                  address:
                     name:Organic Chemistry Synthesis Core Facility, Memorial Sloan-Kettering Cancer Center, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ronald Blasberg
            affiliation:
                  name:Memorial Sloan-Kettering Cancer Center
                  address:
                     name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Juri Gelovani Tjuvajev
            affiliation:
                  name:Memorial Sloan Kettering Cancer Center
                  address:
                     name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
                     type:PostalAddress
                  type:Organization
                  name:MD Anderson Cancer Center
                  address:
                     name:MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:European Journal of Nuclear Medicine and Molecular Imaging
      issn:
         1619-7089
         1619-7070
      volumeNumber:31
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Memorial Sloan Kettering Cancer Center
      address:
         name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
         type:PostalAddress
      name:Memorial Sloan-Kettering Cancer Center
      address:
         name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
         type:PostalAddress
      name:Memorial Sloan-Kettering Cancer Center
      address:
         name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
         type:PostalAddress
      name:Memorial Sloan Kettering Cancer Center
      address:
         name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
         type:PostalAddress
      name:Memorial Sloan Kettering Cancer Center
      address:
         name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
         type:PostalAddress
      name:Memorial Sloan-Kettering Cancer Center
      address:
         name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
         type:PostalAddress
      name:Memorial Sloan-Kettering Cancer Center
      address:
         name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
         type:PostalAddress
      name:Memorial Sloan Kettering Cancer Center
      address:
         name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
         type:PostalAddress
      name:Memorial Sloan Kettering Cancer Center
      address:
         name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
         type:PostalAddress
      name:Memorial Sloan-Kettering Cancer Center
      address:
         name:Radiochemistry/Cyclotron Core Facility, Memorial Sloan-Kettering Cancer Center, New York, USA
         type:PostalAddress
      name:Memorial Sloan-Kettering Cancer Center
      address:
         name:Organic Chemistry Synthesis Core Facility, Memorial Sloan-Kettering Cancer Center, New York, USA
         type:PostalAddress
      name:Memorial Sloan-Kettering Cancer Center
      address:
         name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
         type:PostalAddress
      name:Memorial Sloan Kettering Cancer Center
      address:
         name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
         type:PostalAddress
      name:MD Anderson Cancer Center
      address:
         name:MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Vladimir Ponomarev
      affiliation:
            name:Memorial Sloan Kettering Cancer Center
            address:
               name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
               type:PostalAddress
            type:Organization
      name:Michael Doubrovin
      affiliation:
            name:Memorial Sloan-Kettering Cancer Center
            address:
               name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
               type:PostalAddress
            type:Organization
      name:Inna Serganova
      affiliation:
            name:Memorial Sloan-Kettering Cancer Center
            address:
               name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
               type:PostalAddress
            type:Organization
      name:Jelena Vider
      affiliation:
            name:Memorial Sloan Kettering Cancer Center
            address:
               name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
               type:PostalAddress
            type:Organization
      name:Aleksander Shavrin
      affiliation:
            name:Memorial Sloan Kettering Cancer Center
            address:
               name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
               type:PostalAddress
            type:Organization
      name:Tatiana Beresten
      affiliation:
            name:Memorial Sloan-Kettering Cancer Center
            address:
               name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
               type:PostalAddress
            type:Organization
      name:Anna Ivanova
      affiliation:
            name:Memorial Sloan-Kettering Cancer Center
            address:
               name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
               type:PostalAddress
            type:Organization
      name:Ludmila Ageyeva
      affiliation:
            name:Memorial Sloan Kettering Cancer Center
            address:
               name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
               type:PostalAddress
            type:Organization
      name:Vilia Tourkova
      affiliation:
            name:Memorial Sloan Kettering Cancer Center
            address:
               name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
               type:PostalAddress
            type:Organization
      name:Julius Balatoni
      affiliation:
            name:Memorial Sloan-Kettering Cancer Center
            address:
               name:Radiochemistry/Cyclotron Core Facility, Memorial Sloan-Kettering Cancer Center, New York, USA
               type:PostalAddress
            type:Organization
      name:William Bornmann
      affiliation:
            name:Memorial Sloan-Kettering Cancer Center
            address:
               name:Organic Chemistry Synthesis Core Facility, Memorial Sloan-Kettering Cancer Center, New York, USA
               type:PostalAddress
            type:Organization
      name:Ronald Blasberg
      affiliation:
            name:Memorial Sloan-Kettering Cancer Center
            address:
               name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
               type:PostalAddress
            type:Organization
      name:Juri Gelovani Tjuvajev
      affiliation:
            name:Memorial Sloan Kettering Cancer Center
            address:
               name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
               type:PostalAddress
            type:Organization
            name:MD Anderson Cancer Center
            address:
               name:MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
      name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
      name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
      name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
      name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
      name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
      name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
      name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
      name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
      name:Radiochemistry/Cyclotron Core Facility, Memorial Sloan-Kettering Cancer Center, New York, USA
      name:Organic Chemistry Synthesis Core Facility, Memorial Sloan-Kettering Cancer Center, New York, USA
      name:Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA
      name:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA
      name:MD Anderson Cancer Center, Houston, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(166)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

3.91s.

LINK . SPRINGER . COM {}