We are analyzing https://link.springer.com/article/10.1007/s00251-011-0513-0.

Title:
Functional classification of class II human leukocyte antigen (HLA) molecules reveals seven different supertypes and a surprising degree of repertoire sharing across supertypes | Immunogenetics
Description:
Previous studies have attempted to define human leukocyte antigen (HLA) class II supertypes, analogous to the case for class I, on the basis of shared peptide-binding motifs or structure. In the present study, we determined the binding capacity of a large panel of non-redundant peptides for a set of 27 common HLA DR, DQ, and DP molecules. The measured binding data were then used to define class II supertypes on the basis of shared binding repertoires. Seven different supertypes (main DR, DR4, DRB3, main DQ, DQ7, main DP, and DP2) were defined. The molecules associated with the respective supertypes fell largely along lines defined by MHC locus and reflect, in broad terms, commonalities in reported peptide-binding motifs. Repertoire overlaps between molecules within the same class II supertype were found to be similar in magnitude to what has been observed for HLA class I supertypes. Surprisingly, however, the degree to which repertoires between molecules in the different class II supertypes also overlapped was found to be five to tenfold higher than repertoire overlaps noted between molecules in different class I supertypes. These results highlight a high degree of repertoire overlap amongst all HLA class II molecules, perhaps reflecting binding in multiple registers, and more pronounced dependence on backbone interactions rather than peptide anchor residues. This fundamental difference between HLA class I and class II would not have been predicted on the basis of analysis of either binding motifs or the sequence/predicted structures of the HLA molecules.
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Keywords {🔍}

google, scholar, pubmed, cas, article, class, hla, sette, binding, immunol, sidney, molecules, supertypes, mhc, peptide, human, oseroff, southwood, hladr, motifs, peptides, del, immunogenetics, specificity, guercio, analysis, antigen, peters, peptidebinding, repertoires, epitopes, grey, chung, common, histocompatibility, alleles, structural, privacy, cookies, content, data, functional, leukocyte, repertoire, basis, structure, interactions, polymorphism, nature, protein,

Topics {✒️}

month download article/chapter overlapping peptide-binding repertoires reported peptide-binding motifs shared peptide-binding motifs hla-dr beta chain cd8 t-cell epitopes overlapping binding repertoires hla molecules dqa10501/b10201 dqa10301/b10302 share human leucocyte antigen human ia antigens class ii mhcs full article pdf mouse mhc class worldwide human population peptide binding specificities major hla class privacy choices/manage cookies peptide/hla class class ii supertypes peptide-binding motifs mhc/peptide interactions naturally processed peptides class ii supertype common structural motifs shared binding repertoires article immunogenetics aims antigen fine specificity drb10301 molecules recognize peptide–mhc complexes common hla molecules extensive hla class hla-dr molecule dr binding epitopes peptide-dr interactions influenza virus peptide hla-dr13 alleles hla dr alleles 1-specific binding motif peptide-binding specificity peptide binding specificity cell epitopes access alternative specific submotifs hla-dr molecules promiscuous antigenic peptides natural peptides isolated viral ctl epitopes type hla supertypes amino acid sequence article greenbaum

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