We are analyzing https://link.springer.com/article/10.1007/s002399910012.

Title:
Molecular Evolution of the GATA Family of Transcription Factors: Conservation Within the DNA-Binding Domain | Journal of Molecular Evolution
Description:
The GATA-binding transcription factors comprise a protein family whose members contain either one or two highly conserved zinc finger DNA-binding domains. Members of this group have been identified in organisms ranging from cellular slime mold to vertebrates, including plants, fungi, nematodes, insects, and echinoderms. While much work has been done describing the expression patterns, functional aspects, and target genes for many of these proteins, an evolutionary analysis of the entire family has been lacking. Herein we show that only the C-terminal zinc finger (Cf) and basic domain, which together constitute the GATA-binding domain, are conserved throughout this protein family. Phylogenetic analyses of amino acid sequences demonstrate distinct evolutionary pathways. Analysis of GATA factors isolated from vertebrates suggests that the six distinct vertebrate GATAs are descended from a common ancestral sequence, while those isolated from nonvertebrates (with the exception of the fungal AREA orthologues and Arabidopsis paralogues) appear to be related only within the DNA-binding domain and otherwise provide little insight into their evolutionary history. These results suggest multiple modes of evolution, including gene duplication and modular evolution of GATA factors based upon inclusion of a class IV zinc finger motif. As such, GATA transcription factors represent a group of proteins related solely by their homologous DNA-binding domains. Further analysis of this domain examines the degree of conservation at each amino acid site using the Boltzmann entropy measure, thereby identifying residues critical to preservation of structure and function. Finally, we construct a predictive motif that can accurately identify potential GATA proteins.
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Keywords {🔍}

article, gata, factors, evolution, transcription, family, domain, dnabinding, access, privacy, cookies, content, analysis, journal, molecular, information, publish, search, zinc, finger, proteins, related, data, including, log, research, conservation, lowry, atchley, protein, evolutionary, amino, acid, motif, open, discover, springer, site, function, optional, personal, parties, area, policy, find, track, february, cite, jason, william,

Topics {✒️}

homologous dna-binding domains dna-binding domain published c-terminal zinc finger dna-binding domain boltzmann entropy measure gata-binding domain molecular evolution aims month download article/chapter gata factors based transcription factors gata factors isolated predictive motif proteins related solely molecular evolution protein family amino acid site full article pdf privacy choices/manage cookies distinct vertebrate gatas gata family related subjects check access instant access common ancestral sequence european economic area cellular slime mold fungal area orthologues including gene duplication modular evolution identifying residues critical conditions privacy policy accepting optional cookies journal finder publish article journal main content log february 2000 volume 50 proteins evolution basic domain article lowry article log entire family domain examines article cite information privacy policy personal data evolutionary history books a evolutionary analysis

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         headline:Molecular Evolution of the GATA Family of Transcription Factors: Conservation Within the DNA-Binding Domain
         description: The GATA-binding transcription factors comprise a protein family whose members contain either one or two highly conserved zinc finger DNA-binding domains. Members of this group have been identified in organisms ranging from cellular slime mold to vertebrates, including plants, fungi, nematodes, insects, and echinoderms. While much work has been done describing the expression patterns, functional aspects, and target genes for many of these proteins, an evolutionary analysis of the entire family has been lacking. Herein we show that only the C-terminal zinc finger (Cf) and basic domain, which together constitute the GATA-binding domain, are conserved throughout this protein family. Phylogenetic analyses of amino acid sequences demonstrate distinct evolutionary pathways. Analysis of GATA factors isolated from vertebrates suggests that the six distinct vertebrate GATAs are descended from a common ancestral sequence, while those isolated from nonvertebrates (with the exception of the fungal AREA orthologues and Arabidopsis paralogues) appear to be related only within the DNA-binding domain and otherwise provide little insight into their evolutionary history. These results suggest multiple modes of evolution, including gene duplication and modular evolution of GATA factors based upon inclusion of a class IV zinc finger motif. As such, GATA transcription factors represent a group of proteins related solely by their homologous DNA-binding domains. Further analysis of this domain examines the degree of conservation at each amino acid site using the Boltzmann entropy measure, thereby identifying residues critical to preservation of structure and function. Finally, we construct a predictive motif that can accurately identify potential GATA proteins.
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         Animal Genetics and Genomics
         Cell Biology
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