We are analyzing https://link.springer.com/article/10.1007/s00213-010-1900-1.

Title:
Genetics of caffeine consumption and responses to caffeine | Psychopharmacology
Description:
Rationale Caffeine is widely consumed in foods and beverages and is also used for a variety of medical purposes. Despite its widespread use, relatively little is understood regarding how genetics affects consumption, acute response, or the long-term effects of caffeine. Objective This paper reviews the literature on the genetics of caffeine from the following: (1) twin studies comparing heritability of consumption and of caffeine-related traits, including withdrawal symptoms, caffeine-induced insomnia, and anxiety, (2) association studies linking genetic polymorphisms of metabolic enzymes and target receptors to variations in caffeine response, and (3) case-control and prospective studies examining relationship between polymorphisms associated with variations in caffeine response to risks of Parkinson’s and cardiovascular diseases in habitual caffeine consumers. Results Twin studies find the heritability of caffeine-related traits to range between 0.36 and 0.58. Analysis of polysubstance use shows that predisposition to caffeine use is highly specific to caffeine itself and shares little common disposition to use of other substances. Genome association studies link variations in adenosine and dopamine receptors to caffeine-induced anxiety and sleep disturbances. Polymorphism in the metabolic enzyme cytochrome P-450 is associated with risk of myocardial infarction in caffeine users. Conclusion Modeling based on twin studies reveals that genetics plays a role in individual variability in caffeine consumption and in the direct effects of caffeine. Both pharmacodynamic and pharmacokinetic polymorphisms have been linked to variation in response to caffeine. These studies may help guide future research in the role of genetics in modulating the acute and chronic effects of caffeine.
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Keywords {🔍}

google, scholar, pubmed, cas, caffeine, adenosine, effects, receptor, coffee, genetic, consumption, pharmacol, disease, receptors, clin, genetics, psychiatry, studies, anxiety, risk, article, twin, association, parkinsons, intake, gene, alcohol, response, polymorphisms, cardiovascular, role, panic, res, ther, neurosci, cypa, psychopharmacology, wit, dopamine, sleep, polymorphism, variation, chronic, study, disorder, med, brain, gen, genet, review,

Topics {✒️}

month download article/chapter nas-nrc twin registry central nervous-system—interaction de-melo-neto vl population-based twin study harriet de wit long-term cardiovascular effects systematic mutation screening low-dose caffeine discrimination short-term regular consumption privacy choices/manage cookies adenosine a2a receptor coffee-attributed sleep disturbance a2a receptor activation explore cyp1a2 d2 dopamine receptors full article pdf adenosine 2a receptor adenosine a2a receptors cardiovascular disease access guide future research cytochrome p4501a induction central nervous system xanthine oxidase activities eliana luisi ml adenosine a1 receptor kendler ks adenosine a2 receptors beta-receptor agonists twin studies reveals multivariate genetic analysis brain adenosine receptors swan ge bertino js jr population based sample article psychopharmacology aims neuropsychiatr genet 139b neuropsychiatr genet 141b european economic area exposure assessment considerations menstrual cycle phase navy seal training sea–air–land rat cerebrocortical synaptosomes potentially “druggable” targets fook-chong smc genetics affects consumption case-control study long-term effects inter-individual variation

Questions {❓}

Kawachi I, Colditz GA, Stone CB (1994) Does coffee drinking increase the risk of coronary heart disease?
Kendler KS, Heath AC, Martin NG, Eaves LJ (1987) Symptoms of anxiety and symptoms of depression: same genes, different environments?
Maia L, de Mendonca A (2002) Does caffeine intake protect from Alzheimer’s disease?

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