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Title:
Vitamin D and chronic diseases: the current state of the art | Archives of Toxicology
Description:
The objective was to provide the current state of the art regarding the role of vitamin D in chronic diseases (osteoporosis, cancer, cardiovascular diseases, dementia, autism, type 1 and type 2 diabetes mellitus, male and female fertility). The document was drawn up by panelists that provided their contribution according to their own scientific expertise. Each scientific expert supplied a first draft manuscript on a specific aspect of the document’s topic that was subjected to voting by all experts as “yes” (agreement with the content and/or wording) or “no” (disagreement). The adopted rule was that statements supported by ≥75 % of votes would be immediately accepted, while those with <25 % would be rejected outright. Others would be subjected to further discussion and subsequent voting, where ≥67 % support or, in an eventual third round, a majority of ≥50 % would be needed. This document finds that the current evidence support a role for vitamin D in bone health but not in other health conditions. However, subjects with vitamin D deficiency have been found to be at high risk of developing chronic diseases. Therefore, although at the present time there is not sufficient evidence to recommend vitamin D supplementation as treatment of chronic diseases, the treatment of vitamin D deficiency should be desiderable in order to reduce the risk of developing chronic diseases.
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Topics {✒️}
month download article/chapter cross-sectional spect-china study bischoff-ferrari ha limited-access data set 1-year double-blind rct receptor cdx-2-dependent response abd el-aziz nh abd el-baseer ka randomized double-blind trial solar rich environment case–control study middle-aged korean men autism spectrum disorders genome-wide association study full article pdf pancreatic islet dysfunction kalliopi kotsa renin-angiotensin system san luis obispo cross-sectional study fertility techniques structure privacy choices/manage cookies open access heijboer ac macdonald hm article muscogiuri rickets-related hypocalcaemia rajpert-de meyts de beur sj de boer ih grant wb van meurs jb robarts research institute de boer ra central obesity article archives llewellyn dj de salvia ma autism spectrum disorder developing chronic diseases el-houfey aa european economic area mitochondrial dehydrogenase activity randomized controlled trials bone mineral density bone turnover markers low bone mass low bone density university memory clinic metabolic diseases
Questions {❓}
- Bischoff-Ferrari HA (2012) Which vitamin D oral supplement is best for postmenopausal women?
- Boucher BJ (1998) Inadequate vitamin D status: Does it contribute to the disorders comprising syndrome ‘X’?
- Mathieu C (2015) Vitamin D and diabetes: Where do we stand?
- Pilz S, Gaksch M, O’Hartaigh B, Tomaschitz A, Marz W (2013) The role of vitamin D deficiency in cardiovascular diseases: Where do we stand in 2013?
- Ramlau-Hansen CH, Moeller UK, Bonde JP, Olsen J, Thulstrup AM (2011) Are serum levels of vitamin D associated with semen quality?
- Stubbs G, Henley K, Green J (2016) Autism: Will vitamin D supplementation during pregnancy and early childhood reduce the recurrence rate of autism in newborn siblings?
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headline:Vitamin D and chronic diseases: the current state of the art
description:The objective was to provide the current state of the art regarding the role of vitamin D in chronic diseases (osteoporosis, cancer, cardiovascular diseases, dementia, autism, type 1 and type 2 diabetes mellitus, male and female fertility). The document was drawn up by panelists that provided their contribution according to their own scientific expertise. Each scientific expert supplied a first draft manuscript on a specific aspect of the document’s topic that was subjected to voting by all experts as “yes” (agreement with the content and/or wording) or “no” (disagreement). The adopted rule was that statements supported by ≥75 % of votes would be immediately accepted, while those with <25 % would be rejected outright. Others would be subjected to further discussion and subsequent voting, where ≥67 % support or, in an eventual third round, a majority of ≥50 % would be needed. This document finds that the current evidence support a role for vitamin D in bone health but not in other health conditions. However, subjects with vitamin D deficiency have been found to be at high risk of developing chronic diseases. Therefore, although at the present time there is not sufficient evidence to recommend vitamin D supplementation as treatment of chronic diseases, the treatment of vitamin D deficiency should be desiderable in order to reduce the risk of developing chronic diseases.
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name:University Hospital “S. Giovanni di Dio e Ruggi d’Aragona”
address:
name:Department of Endocrinology and Diabetology, Fertility Techniques Structure, University Hospital “S. Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italy
type:PostalAddress
type:Organization
name:“Parthenope” University Naples
address:
name:Department of Sports Science and Wellness, “Parthenope” University Naples, Naples, Italy
type:PostalAddress
type:Organization
name:Stefan Pilz
affiliation:
name:Medical University of Graz
address:
name:Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria
type:PostalAddress
type:Organization
name:VU University Medical Center
address:
name:Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
type:PostalAddress
type:Organization
name:Giacomo Tirabassi
affiliation:
name:Polytechnic University of Marche
address:
name:Division of Endocrinology, Department of Clinical and Molecular Sciences, Umberto I Hospital, Polytechnic University of Marche, Ancona, Italy
type:PostalAddress
type:Organization
name:Annamaria Colao
affiliation:
name:University “Federico II”
address:
name:Department of Clinical Medicine and Surgery, University “Federico II”, Naples, Italy
type:PostalAddress
type:Organization
PostalAddress:
name:Ios and Coleman Medicina Futura Medical Center, University “Federico II”, Naples, Italy
name:Department of Endocrinology and Metabolic Diseases, Catholic University of the Sacred Heart, Rome, Italy
name:Division of Geriatric Medicine, Department of Neuroscience, Angers University Hospital, University Memory Clinic, UPRES EA 4638, University of Angers, UNAM, Angers, France
name:Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Robarts Research Institute, The University of Western Ontario, London, Canada
name:Division of Endocrinology, Department of Clinical and Molecular Sciences, Umberto I Hospital, Polytechnic University of Marche, Ancona, Italy
name:Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
name:The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
name:Vitamin D Council, San Luis Obispo, USA
name:Department of Medicine, Operative Unit of Andrology and Medicine of Human Reproduction, University of Padova, Padua, Italy
name:Department of Cardiology, Swiss Cardiovascular Center Bern, Bern University Hospital, Bern, Switzerland
name:Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria
name:Division of Endocrinology and Metabolism, Department of Medicine, AHEPA University Hospital, Thessaloníki, Greece
name:Comando Brigata Alpina “Julia”/Multinational Land Force, Medical Service, Udine, Italy
name:Medical Clinic V (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany
name:Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
name:Synlab Academy, Synlab Holding Germany GmbH, Mannheim, Augsburg, Germany
name:Department of Endocrinology and Diabetology, Fertility Techniques Structure, University Hospital “S. Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italy
name:Department of Sports Science and Wellness, “Parthenope” University Naples, Naples, Italy
name:Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria
name:Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
name:Division of Endocrinology, Department of Clinical and Molecular Sciences, Umberto I Hospital, Polytechnic University of Marche, Ancona, Italy
name:Department of Clinical Medicine and Surgery, University “Federico II”, Naples, Italy
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