We are analyzing https://link.springer.com/article/10.1007/s00203-024-03914-8.

Title:
Postbiotic butyrate: role and its effects for being a potential drug and biomarker to pancreatic cancer | Archives of Microbiology
Description:
Postbiotics are produced by microbes and have recently gained importance in the field of oncology due to their beneficial effects to the host, effectiveness against cancer cells, and their ability to suppress inflammation. In particular, butyrate dominates over all other postbiotics both in quantity and anticancer properties. Pancreatic cancer (PC), being one of the most malignant and lethal cancers, reported a decreased 5-year survival rate in less than 10% of the patients. PC causes an increased mortality rate due to its inability to be detected at an early stage but still a promising strategy for its diagnosis has not been achieved yet. It is necessary to diagnose Pancreatic cancer before the metastatic progression stage. The available blood biomarkers lack accurate and proficient diagnostic results. Postbiotic butyrate is produced by gut microbiota such as Rhuminococcus and Faecalibacterium it is involved in cell signalling pathways, autophagy, and cell cycle regulation, and reduction in butyrate concentration is associated with the occurrence of pancreatic cancer. The postbiotic butyrate is a potential biomarker that could detect PC at an early stage, before the metastatic progression stage. Thus, this review focused on the gut microbiota butyrate’s role in pancreatic cancer and the immuno-suppressive environment, its effects on histone deacetylase and other immune cells, microbes in major butyrate synthesis pathways, current biomarkers in use for Pancreatic Cancer.
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Keywords {🔍}

pubmed, cancer, article, google, scholar, pancreatic, cas, central, zhang, gut, butyrate, wang, microbiome, biomarkers, patients, microbiota, potential, cell, liu, huang, res, httpsdoiorgs, tumor, biomarker, cancers, role, signaling, fatty, antigen, httpsdoiorgcancers, sci, shortchain, cells, ductal, adenocarcinoma, basel, clin, gastroenterol, chen, detection, acids, review, diagnosis, diagnostic, immune, dong, zhou, httpsdoiorg, human, research,

Topics {✒️}

year-pancreatic-cancer-survival-rate-increases month download article/chapter wnt/β-catenin signaling pathway orai1-mediated antimicrobial secretion iddf2018-abs-0023 butyrate acid enhances anti-pd1 efficacy β-catenin/cbp interaction gov/statfacts/html/pancreas ink4a/arf deficiency cooperate intestinal microbial-elaborated butyrate stable blood-based markers article elango intestinal tumour growth lamina propria macrophages gut microbiome-related aspects full article pdf faecal microbiota signature del vecchio le human large intestine metabolomic profile microbial metabolite signaling blood-based biomarkers gut microbiota butyrate circulating mir-106b-3p oncogenic signaling pathways arunkumar radhakrishnan privacy choices/manage cookies periodontitis–cancer association early-stage pancreatic cancer elevated systemic levels zambirinis cp fecal microbiota transplantation bmj publishing group article archives human tumor microbiome butyrate-producing bacteria butyrate suppresses expression pancreatic ductal adenocarcinoma de muckadell obs van grieken nct van laarhoven hwm van santvoort hc egfr/p38 signaling cancer patient care gut microbiota modulation tgf-β type iii collagen th17/treg cell salivary transcriptomic biomarkers differentiation therapy targeting

Questions {❓}

Can we fight it?
Dong Y, Zhang K, Wei J, Ding Y, Wang X, Hou H, Wu J, Liu T, Wang B, Cao H (2023) Gut microbiota-derived short-chain fatty acids regulate gastrointestinal tumor immunity: a novel therapeutic strategy?
Montemagno C, Cassim S, De Leiris N, Durivault J, Faraggi M, Pagès G (2021) Pancreatic ductal adenocarcinoma: the dawn of the era of nuclear medicine?
O’Neill RS, Stoita A (2021) Biomarkers in the diagnosis of pancreatic cancer: are we closer to finding the golden ticket?
Papazoglou D, Papatheodorou K, Papanas N, Papadopoulos T, Gioka T, Kabouromiti G, Kotsiou S, Maltezos E (2010) Matrix metalloproteinase-1 and tissue inhibitor of metalloproteinases-1 levels in severely obese patients: what is the effect of weight loss?
Pfisterer N, Lingens C, Heuer C, Dang L, Neesse A, Ammer-Herrmenau C (2022) The microbiome in PDAC—vantage point for future therapies?
Tarasiuk A, Mackiewicz T, Małecka-Panas E, Fichna J (2021) Biomarkers for early detection of pancreatic cancer - miRNAs as a potential diagnostic and therapeutic tool?
Toni G (2021) What are postbiotics?

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