We are analyzing https://link.springer.com/article/10.1007/s00018-014-1771-4.

Title:
Iron transport across the blood–brain barrier: development, neurovascular regulation and cerebral amyloid angiopathy | Cellular and Molecular Life Sciences
Description:
There are two barriers for iron entry into the brain: (1) the brain–cerebrospinal fluid (CSF) barrier and (2) the blood–brain barrier (BBB). Here, we review the literature on developmental iron accumulation by the brain, focusing on the transport of iron through the brain microvascular endothelial cells (BMVEC) of the BBB. We review the iron trafficking proteins which may be involved in the iron flux across BMVEC and discuss the plausible mechanisms of BMVEC iron uptake and efflux. We suggest a model for how BMVEC iron uptake and efflux are regulated and a mechanism by which the majority of iron is trafficked across the developing BBB under the direct guidance of neighboring astrocytes. Thus, we place brain iron uptake in the context of the neurovascular unit of the adult brain. Last, we propose that BMVEC iron is involved in the aggregation of amyloid-β peptides leading to the progression of cerebral amyloid angiopathy which often occurs prior to dementia and the onset of Alzheimer’s disease.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Business & Finance

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 8,151,168 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don't see any clear sign of profit-making.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

pubmed, google, scholar, cas, iron, central, brain, transferrin, biol, cell, ferroportin, cells, rat, protein, chem, physiol, expression, res, transport, transporter, uptake, ceruloplasmin, human, sci, mol, cellular, amyloid, biochem, barrier, receptor, neurosci, bloodbrain, endothelial, astrocytes, blood, hepcidin, precursor, ferritin, article, proteins, mechanism, alzheimers, disease, metal, zip, copper, proc, divalent, hephaestin, distribution,

Topics {✒️}

month download article/chapter blood–brain–cerebrospinal fluid system β-amyloid precursor protein cyclic amp-protein kinase autosomal-dominant hemochrom-atosis colorimetric ferrozine-based assay amyloid-β peptides leading central nervous system metal cation-binding sites cerebral β-amyloid deposition 31p-mrs-based determination plasma membrane proton-adenosinetriphosphatases n-lobe monoferric transferrins iron-regulating protein hepcidin cells expressing gpi-ceruloplasmin anti-transferrin receptor antibody disease peptide β-amyloid atp-driven copper transport high-affinity transferrin receptor conserved iron-responsive elements ferroportin-mediated iron transport iron-export ferroxidase activity 2-amyloid precursor protein amyloid precursor protein iron-zinc interaction astrocyte-endothelial interactions transferrin-bound iron uptake duodenal iron-regulated transporter hepcidin-mediated internalization blood–brain barrier blood-brain-barrier hepcidin-induced endocytosis privacy choices/manage cookies cerebral amyloid angiopathy +-coupled fe2+ transport nramp2/dmt1 iron transporter brain barrier systems iron-regulated ferric reductase intestinal brush border major β-secretase iron regulatory protein-1 regulatory rna sequences x-ray structure beta-amyloid expression age-dependent uptake manganese-responsive protein γ-secretase activity divalent metal transporter intestinal iron transport full article pdf

Questions {❓}

Broersen K, Rousseau F, Schymkowitz J (2010) The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer’s disease: oligomer size or conformation?
Garrick MD et al (2006) DMT1: which metals does it transport?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Iron transport across the blood–brain barrier: development, neurovascular regulation and cerebral amyloid angiopathy
         description:There are two barriers for iron entry into the brain: (1) the brain–cerebrospinal fluid (CSF) barrier and (2) the blood–brain barrier (BBB). Here, we review the literature on developmental iron accumulation by the brain, focusing on the transport of iron through the brain microvascular endothelial cells (BMVEC) of the BBB. We review the iron trafficking proteins which may be involved in the iron flux across BMVEC and discuss the plausible mechanisms of BMVEC iron uptake and efflux. We suggest a model for how BMVEC iron uptake and efflux are regulated and a mechanism by which the majority of iron is trafficked across the developing BBB under the direct guidance of neighboring astrocytes. Thus, we place brain iron uptake in the context of the neurovascular unit of the adult brain. Last, we propose that BMVEC iron is involved in the aggregation of amyloid-β peptides leading to the progression of cerebral amyloid angiopathy which often occurs prior to dementia and the onset of Alzheimer’s disease.
         datePublished:2014-10-30T00:00:00Z
         dateModified:2014-10-30T00:00:00Z
         pageStart:709
         pageEnd:727
         sameAs:https://doi.org/10.1007/s00018-014-1771-4
         keywords:
            Iron
            Blood–brain barrier
            Astrocytes
            Transferrin
            Amyloid precursor protein
            Cell Biology
            Biomedicine
            general
            Life Sciences
            Biochemistry
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-014-1771-4/MediaObjects/18_2014_1771_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-014-1771-4/MediaObjects/18_2014_1771_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-014-1771-4/MediaObjects/18_2014_1771_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-014-1771-4/MediaObjects/18_2014_1771_Fig4_HTML.gif
         isPartOf:
            name:Cellular and Molecular Life Sciences
            issn:
               1420-9071
               1420-682X
            volumeNumber:72
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Basel
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Ryan C. McCarthy
               affiliation:
                     name:University at Buffalo, School of Medicine and Biomedical Sciences
                     address:
                        name:Department of Biochemistry, University at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Daniel J. Kosman
               affiliation:
                     name:University at Buffalo, School of Medicine and Biomedical Sciences
                     address:
                        name:Department of Biochemistry, University at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Iron transport across the blood–brain barrier: development, neurovascular regulation and cerebral amyloid angiopathy
      description:There are two barriers for iron entry into the brain: (1) the brain–cerebrospinal fluid (CSF) barrier and (2) the blood–brain barrier (BBB). Here, we review the literature on developmental iron accumulation by the brain, focusing on the transport of iron through the brain microvascular endothelial cells (BMVEC) of the BBB. We review the iron trafficking proteins which may be involved in the iron flux across BMVEC and discuss the plausible mechanisms of BMVEC iron uptake and efflux. We suggest a model for how BMVEC iron uptake and efflux are regulated and a mechanism by which the majority of iron is trafficked across the developing BBB under the direct guidance of neighboring astrocytes. Thus, we place brain iron uptake in the context of the neurovascular unit of the adult brain. Last, we propose that BMVEC iron is involved in the aggregation of amyloid-β peptides leading to the progression of cerebral amyloid angiopathy which often occurs prior to dementia and the onset of Alzheimer’s disease.
      datePublished:2014-10-30T00:00:00Z
      dateModified:2014-10-30T00:00:00Z
      pageStart:709
      pageEnd:727
      sameAs:https://doi.org/10.1007/s00018-014-1771-4
      keywords:
         Iron
         Blood–brain barrier
         Astrocytes
         Transferrin
         Amyloid precursor protein
         Cell Biology
         Biomedicine
         general
         Life Sciences
         Biochemistry
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-014-1771-4/MediaObjects/18_2014_1771_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-014-1771-4/MediaObjects/18_2014_1771_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-014-1771-4/MediaObjects/18_2014_1771_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-014-1771-4/MediaObjects/18_2014_1771_Fig4_HTML.gif
      isPartOf:
         name:Cellular and Molecular Life Sciences
         issn:
            1420-9071
            1420-682X
         volumeNumber:72
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Basel
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Ryan C. McCarthy
            affiliation:
                  name:University at Buffalo, School of Medicine and Biomedical Sciences
                  address:
                     name:Department of Biochemistry, University at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Daniel J. Kosman
            affiliation:
                  name:University at Buffalo, School of Medicine and Biomedical Sciences
                  address:
                     name:Department of Biochemistry, University at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cellular and Molecular Life Sciences
      issn:
         1420-9071
         1420-682X
      volumeNumber:72
Organization:
      name:Springer Basel
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University at Buffalo, School of Medicine and Biomedical Sciences
      address:
         name:Department of Biochemistry, University at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, USA
         type:PostalAddress
      name:University at Buffalo, School of Medicine and Biomedical Sciences
      address:
         name:Department of Biochemistry, University at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Ryan C. McCarthy
      affiliation:
            name:University at Buffalo, School of Medicine and Biomedical Sciences
            address:
               name:Department of Biochemistry, University at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, USA
               type:PostalAddress
            type:Organization
      name:Daniel J. Kosman
      affiliation:
            name:University at Buffalo, School of Medicine and Biomedical Sciences
            address:
               name:Department of Biochemistry, University at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Biochemistry, University at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, USA
      name:Department of Biochemistry, University at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(459)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.67s.

LINK . SPRINGER . COM {}